Case report: Osteosarcomatous differentiation in the lung metastasis of a malignant phyllodes tumor
Malignant phyllodes tumor is a rare breast tumor, with distant metastases and heterologous differentiation in a few cases. We report a case of malignant phyllodes tumor with liposarcomatous differentiation in the primary tumor and osteosarcomatous differentiation in the lung metastatic tumor. A midd...
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Frontiers Media S.A.
2023-03-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2023.1141353/full |
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| author | Ruijing Liu Ruijing Liu Jingli Xue Jingli Xue Wen Liu Wen Liu Beibei Jiang Beibei Jiang Fuyun Shi Zhenzheng Wang Peifeng Li Peifeng Li |
| author_facet | Ruijing Liu Ruijing Liu Jingli Xue Jingli Xue Wen Liu Wen Liu Beibei Jiang Beibei Jiang Fuyun Shi Zhenzheng Wang Peifeng Li Peifeng Li |
| author_sort | Ruijing Liu |
| collection | DOAJ |
| description | Malignant phyllodes tumor is a rare breast tumor, with distant metastases and heterologous differentiation in a few cases. We report a case of malignant phyllodes tumor with liposarcomatous differentiation in the primary tumor and osteosarcomatous differentiation in the lung metastatic tumor. A middle-aged female presented with a well-defined mass in the upper lobe of the right lung measuring 5.0 × 5.0 × 3.0 cm. The patient had a history of malignant phyllodes tumor in the breast. The patient underwent a right superior lobectomy. Histologically, the primary tumor was a typical malignant phyllodes tumor with pleomorphic liposarcomatous differentiation, while the lung metastasis showed osteosarcomatous differentiation without original biphasic features. The phyllodes tumor and heterologous components showed CD10 and p53 expression, and were negative for ER, PR, and CD34. Exome sequencing revealed TP53, TERT, EGFR, RARA, RB1, and GNAS mutations in all three components. Although the lung metastasis were morphologically different from the primary breast tumor, their common origin was demonstrated through immunohistochemical and molecular characterization. Cancer stem cells give rise to tumor heterogeneous cells, and heterologous components in malignant phyllodes tumors may indicate unfavorable prognosis and a greater risk of early recurrence and metastasis. |
| first_indexed | 2024-04-09T23:30:24Z |
| format | Article |
| id | doaj.art-1538692b396645858719a93e9fac7dfb |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-04-09T23:30:24Z |
| publishDate | 2023-03-01 |
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| series | Frontiers in Medicine |
| spelling | doaj.art-1538692b396645858719a93e9fac7dfb2023-03-21T05:41:07ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2023-03-011010.3389/fmed.2023.11413531141353Case report: Osteosarcomatous differentiation in the lung metastasis of a malignant phyllodes tumorRuijing Liu0Ruijing Liu1Jingli Xue2Jingli Xue3Wen Liu4Wen Liu5Beibei Jiang6Beibei Jiang7Fuyun Shi8Zhenzheng Wang9Peifeng Li10Peifeng Li11Department of Pathology, The Postgraduate Training Base of Jinzhou Medical University (The 960th Hospital of PLA), Jinan, ChinaDepartment of Pathology, The 960th Hospital of PLA, Jinan, ChinaDepartment of Pathology, The Postgraduate Training Base of Jinzhou Medical University (The 960th Hospital of PLA), Jinan, ChinaDepartment of Pathology, The 960th Hospital of PLA, Jinan, ChinaDepartment of Pathology, The Postgraduate Training Base of Jinzhou Medical University (The 960th Hospital of PLA), Jinan, ChinaDepartment of Pathology, The 960th Hospital of PLA, Jinan, ChinaDepartment of Pathology, The Postgraduate Training Base of Jinzhou Medical University (The 960th Hospital of PLA), Jinan, ChinaDepartment of Pathology, The Fourth People’s Hospital of Jinan, Jinan, ChinaDepartment of Pathology, The 960th Hospital of PLA, Jinan, ChinaDepartment of Pathology, The 960th Hospital of PLA, Jinan, ChinaDepartment of Pathology, The Postgraduate Training Base of Jinzhou Medical University (The 960th Hospital of PLA), Jinan, ChinaDepartment of Pathology, The 960th Hospital of PLA, Jinan, ChinaMalignant phyllodes tumor is a rare breast tumor, with distant metastases and heterologous differentiation in a few cases. We report a case of malignant phyllodes tumor with liposarcomatous differentiation in the primary tumor and osteosarcomatous differentiation in the lung metastatic tumor. A middle-aged female presented with a well-defined mass in the upper lobe of the right lung measuring 5.0 × 5.0 × 3.0 cm. The patient had a history of malignant phyllodes tumor in the breast. The patient underwent a right superior lobectomy. Histologically, the primary tumor was a typical malignant phyllodes tumor with pleomorphic liposarcomatous differentiation, while the lung metastasis showed osteosarcomatous differentiation without original biphasic features. The phyllodes tumor and heterologous components showed CD10 and p53 expression, and were negative for ER, PR, and CD34. Exome sequencing revealed TP53, TERT, EGFR, RARA, RB1, and GNAS mutations in all three components. Although the lung metastasis were morphologically different from the primary breast tumor, their common origin was demonstrated through immunohistochemical and molecular characterization. Cancer stem cells give rise to tumor heterogeneous cells, and heterologous components in malignant phyllodes tumors may indicate unfavorable prognosis and a greater risk of early recurrence and metastasis.https://www.frontiersin.org/articles/10.3389/fmed.2023.1141353/fullmalignant phyllodes tumorosteosarcomatous differentiationliposarcomatous differentiationtumor metastasiscancer stem cellscase report |
| spellingShingle | Ruijing Liu Ruijing Liu Jingli Xue Jingli Xue Wen Liu Wen Liu Beibei Jiang Beibei Jiang Fuyun Shi Zhenzheng Wang Peifeng Li Peifeng Li Case report: Osteosarcomatous differentiation in the lung metastasis of a malignant phyllodes tumor Frontiers in Medicine malignant phyllodes tumor osteosarcomatous differentiation liposarcomatous differentiation tumor metastasis cancer stem cells case report |
| title | Case report: Osteosarcomatous differentiation in the lung metastasis of a malignant phyllodes tumor |
| title_full | Case report: Osteosarcomatous differentiation in the lung metastasis of a malignant phyllodes tumor |
| title_fullStr | Case report: Osteosarcomatous differentiation in the lung metastasis of a malignant phyllodes tumor |
| title_full_unstemmed | Case report: Osteosarcomatous differentiation in the lung metastasis of a malignant phyllodes tumor |
| title_short | Case report: Osteosarcomatous differentiation in the lung metastasis of a malignant phyllodes tumor |
| title_sort | case report osteosarcomatous differentiation in the lung metastasis of a malignant phyllodes tumor |
| topic | malignant phyllodes tumor osteosarcomatous differentiation liposarcomatous differentiation tumor metastasis cancer stem cells case report |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2023.1141353/full |
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