Pelargonidin Improves Passive Avoidance Task Performance in a Rat Amyloid Beta25-35 Model of Alzheimer’s Disease Via Estrogen Receptor Independent Pathways
Alzheimer’s disease (AD) is a disorder with multiple pathophysiological causes, destructive outcomes, and no available definitive cure. Pelargonidin (Pel), an anthocyanin derivative, is an estrogen receptor agonist with little estrogen side effects. This study was designed to assess Pel memory enhan...
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2016-05-01
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| Series: | Acta Medica Iranica |
| Subjects: | |
| Online Access: | https://acta.tums.ac.ir/index.php/acta/article/view/4980 |
| _version_ | 1818039694261223424 |
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| author | Hamid Sohanaki Tourandokht Baluchnejadmojarad Farnaz Nikbakht Mehrdad Roghani |
| author_facet | Hamid Sohanaki Tourandokht Baluchnejadmojarad Farnaz Nikbakht Mehrdad Roghani |
| author_sort | Hamid Sohanaki |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is a disorder with multiple pathophysiological causes, destructive outcomes, and no available definitive cure. Pelargonidin (Pel), an anthocyanin derivative, is an estrogen receptor agonist with little estrogen side effects. This study was designed to assess Pel memory enhancing effects on the a rat Amyloid Beta25-35 (Aβ) intrahippocampal microinjections model of AD in the passive avoidance task performance paradigm and further evaluate the potential estrogen receptor role on the memory-evoking compound. Equally divided rats were assigned to 5 groups of sham, Aβ intrahippocampal microinjected, Pel pretreated (10 mg/kg; P.O), α estrogen antagonist intra-cerebrovascular (i.c.v.) microinjected, and β estrogen antagonist (i.c.v) microinjected animals. Intrahippocampal microinjections of Aβ were adopted to provoke AD model. Passive avoidance task test was also used to assess memory performance. Pel pretreatment prior to Aβ microinjections significantly improved step-through latency (P<0.001) in passive avoidance test. In α and β estrogen, antagonists received animals, passive avoidance task performance was not statistically changed (P=0.11 & P=0.41 respectively) compared to Pel pretreated and sham animals. Our results depicted that Pel improves Aβ induced memory dysfunction in passive avoidance test performance through estrogen receptor independently related pathways. |
| first_indexed | 2024-12-10T08:02:42Z |
| format | Article |
| id | doaj.art-1539966cd04f481e8dd9d94db7cb3afe |
| institution | Directory Open Access Journal |
| issn | 0044-6025 1735-9694 |
| language | English |
| last_indexed | 2024-12-10T08:02:42Z |
| publishDate | 2016-05-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Acta Medica Iranica |
| spelling | doaj.art-1539966cd04f481e8dd9d94db7cb3afe2022-12-22T01:56:45ZengTehran University of Medical SciencesActa Medica Iranica0044-60251735-96942016-05-015444985Pelargonidin Improves Passive Avoidance Task Performance in a Rat Amyloid Beta25-35 Model of Alzheimer’s Disease Via Estrogen Receptor Independent PathwaysHamid Sohanaki0Tourandokht Baluchnejadmojarad1Farnaz Nikbakht2Mehrdad Roghani3Department of Physiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran. AND Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.Neurophysiology Research Center, Shahed University, Tehran, Iran.Alzheimer’s disease (AD) is a disorder with multiple pathophysiological causes, destructive outcomes, and no available definitive cure. Pelargonidin (Pel), an anthocyanin derivative, is an estrogen receptor agonist with little estrogen side effects. This study was designed to assess Pel memory enhancing effects on the a rat Amyloid Beta25-35 (Aβ) intrahippocampal microinjections model of AD in the passive avoidance task performance paradigm and further evaluate the potential estrogen receptor role on the memory-evoking compound. Equally divided rats were assigned to 5 groups of sham, Aβ intrahippocampal microinjected, Pel pretreated (10 mg/kg; P.O), α estrogen antagonist intra-cerebrovascular (i.c.v.) microinjected, and β estrogen antagonist (i.c.v) microinjected animals. Intrahippocampal microinjections of Aβ were adopted to provoke AD model. Passive avoidance task test was also used to assess memory performance. Pel pretreatment prior to Aβ microinjections significantly improved step-through latency (P<0.001) in passive avoidance test. In α and β estrogen, antagonists received animals, passive avoidance task performance was not statistically changed (P=0.11 & P=0.41 respectively) compared to Pel pretreated and sham animals. Our results depicted that Pel improves Aβ induced memory dysfunction in passive avoidance test performance through estrogen receptor independently related pathways.https://acta.tums.ac.ir/index.php/acta/article/view/4980Alzheimer’s diseaseHippocampusPelargonidinMemory dysfunctionPassive avoidance testEstrogen receptor |
| spellingShingle | Hamid Sohanaki Tourandokht Baluchnejadmojarad Farnaz Nikbakht Mehrdad Roghani Pelargonidin Improves Passive Avoidance Task Performance in a Rat Amyloid Beta25-35 Model of Alzheimer’s Disease Via Estrogen Receptor Independent Pathways Acta Medica Iranica Alzheimer’s disease Hippocampus Pelargonidin Memory dysfunction Passive avoidance test Estrogen receptor |
| title | Pelargonidin Improves Passive Avoidance Task Performance in a Rat Amyloid Beta25-35 Model of Alzheimer’s Disease Via Estrogen Receptor Independent Pathways |
| title_full | Pelargonidin Improves Passive Avoidance Task Performance in a Rat Amyloid Beta25-35 Model of Alzheimer’s Disease Via Estrogen Receptor Independent Pathways |
| title_fullStr | Pelargonidin Improves Passive Avoidance Task Performance in a Rat Amyloid Beta25-35 Model of Alzheimer’s Disease Via Estrogen Receptor Independent Pathways |
| title_full_unstemmed | Pelargonidin Improves Passive Avoidance Task Performance in a Rat Amyloid Beta25-35 Model of Alzheimer’s Disease Via Estrogen Receptor Independent Pathways |
| title_short | Pelargonidin Improves Passive Avoidance Task Performance in a Rat Amyloid Beta25-35 Model of Alzheimer’s Disease Via Estrogen Receptor Independent Pathways |
| title_sort | pelargonidin improves passive avoidance task performance in a rat amyloid beta25 35 model of alzheimer s disease via estrogen receptor independent pathways |
| topic | Alzheimer’s disease Hippocampus Pelargonidin Memory dysfunction Passive avoidance test Estrogen receptor |
| url | https://acta.tums.ac.ir/index.php/acta/article/view/4980 |
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