Association of adiponectin gene G276T polymorphism with the development of metabolic syndrome in ethnic Kyrgyz patients
Aim. To study the association of adiponectin gene G276Т (ADIPOQ) polymorphism with the development of metabolic syndrome (MS) in ethnic Kyrgyz patients. Subjects and methods. A total of 171 patients with MS (a study group) and 117 patients without MS (a comparison group) were examined. MS was define...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | Russian |
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"Consilium Medicum" Publishing house
2015-10-01
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| Series: | Терапевтический архив |
| Subjects: | |
| Online Access: | https://ter-arkhiv.ru/0040-3660/article/view/31845 |
| _version_ | 1818923178382065664 |
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| author | J T Isakova O S Lunegova E T Talaibekova D A Asambaeva A S Kerimkulova A A Aldashev |
| author_facet | J T Isakova O S Lunegova E T Talaibekova D A Asambaeva A S Kerimkulova A A Aldashev |
| author_sort | J T Isakova |
| collection | DOAJ |
| description | Aim. To study the association of adiponectin gene G276Т (ADIPOQ) polymorphism with the development of metabolic syndrome (MS) in ethnic Kyrgyz patients. Subjects and methods. A total of 171 patients with MS (a study group) and 117 patients without MS (a comparison group) were examined. MS was defined on the basis of the modified ATP III criteria. The genotypes of the G276T polymorphism in the adiponectin gene were determined by polymerase chain reaction-restriction fragment length polymorphism analysis. Results. Dividing the MS and control groups by gender revealed statistically significant differences in the distribution of alleles and genotypes only among the women. There was a higher frequency of GT+TT genotypes (53% vs 34%; χ2=5.942; р=0.014) and T allele (30% vs 19%; χ2=4.489; р=0.0341) in the women with MS than in those without MS. Iin the ethnic Kyrgyz women, the T allele at the G276Т polymorphic locus in the ADIPOQ gene was associated with the development of MS (odds ratio (OR)=1.82; 95% confidence interval (CI) 1.04—3.19) and type 2 diabetes mellitus (T2DM) (OR=2.63; 95% CI, 1.05—6.56 ) with the high levels of leptin (p |
| first_indexed | 2024-12-20T02:05:18Z |
| format | Article |
| id | doaj.art-153c27786cb44f48a2c59edd191aa8c2 |
| institution | Directory Open Access Journal |
| issn | 0040-3660 2309-5342 |
| language | Russian |
| last_indexed | 2024-12-20T02:05:18Z |
| publishDate | 2015-10-01 |
| publisher | "Consilium Medicum" Publishing house |
| record_format | Article |
| series | Терапевтический архив |
| spelling | doaj.art-153c27786cb44f48a2c59edd191aa8c22022-12-21T19:57:12Zrus"Consilium Medicum" Publishing houseТерапевтический архив0040-36602309-53422015-10-018710859028861Association of adiponectin gene G276T polymorphism with the development of metabolic syndrome in ethnic Kyrgyz patientsJ T IsakovaO S LunegovaE T TalaibekovaD A AsambaevaA S KerimkulovaA A AldashevAim. To study the association of adiponectin gene G276Т (ADIPOQ) polymorphism with the development of metabolic syndrome (MS) in ethnic Kyrgyz patients. Subjects and methods. A total of 171 patients with MS (a study group) and 117 patients without MS (a comparison group) were examined. MS was defined on the basis of the modified ATP III criteria. The genotypes of the G276T polymorphism in the adiponectin gene were determined by polymerase chain reaction-restriction fragment length polymorphism analysis. Results. Dividing the MS and control groups by gender revealed statistically significant differences in the distribution of alleles and genotypes only among the women. There was a higher frequency of GT+TT genotypes (53% vs 34%; χ2=5.942; р=0.014) and T allele (30% vs 19%; χ2=4.489; р=0.0341) in the women with MS than in those without MS. Iin the ethnic Kyrgyz women, the T allele at the G276Т polymorphic locus in the ADIPOQ gene was associated with the development of MS (odds ratio (OR)=1.82; 95% confidence interval (CI) 1.04—3.19) and type 2 diabetes mellitus (T2DM) (OR=2.63; 95% CI, 1.05—6.56 ) with the high levels of leptin (phttps://ter-arkhiv.ru/0040-3660/article/view/31845g276t polymorphism in the adiponectin (adipoq) genemetabolic syndromeleptinkyrgyz population |
| spellingShingle | J T Isakova O S Lunegova E T Talaibekova D A Asambaeva A S Kerimkulova A A Aldashev Association of adiponectin gene G276T polymorphism with the development of metabolic syndrome in ethnic Kyrgyz patients Терапевтический архив g276t polymorphism in the adiponectin (adipoq) gene metabolic syndrome leptin kyrgyz population |
| title | Association of adiponectin gene G276T polymorphism with the development of metabolic syndrome in ethnic Kyrgyz patients |
| title_full | Association of adiponectin gene G276T polymorphism with the development of metabolic syndrome in ethnic Kyrgyz patients |
| title_fullStr | Association of adiponectin gene G276T polymorphism with the development of metabolic syndrome in ethnic Kyrgyz patients |
| title_full_unstemmed | Association of adiponectin gene G276T polymorphism with the development of metabolic syndrome in ethnic Kyrgyz patients |
| title_short | Association of adiponectin gene G276T polymorphism with the development of metabolic syndrome in ethnic Kyrgyz patients |
| title_sort | association of adiponectin gene g276t polymorphism with the development of metabolic syndrome in ethnic kyrgyz patients |
| topic | g276t polymorphism in the adiponectin (adipoq) gene metabolic syndrome leptin kyrgyz population |
| url | https://ter-arkhiv.ru/0040-3660/article/view/31845 |
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