Temperature sensitive nanogels for real-time imaging during transcatheter arterial embolization
Several vascular embolization materials are commonly used in clinical practice, however, having application defects of varying degrees, such as poor intraoperative imaging and easy recanalization of embolized blood vessels, they are challenging for application during Transcatheter arterial embolizat...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Designed Monomers and Polymers |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/15685551.2022.2164445 |
| _version_ | 1827585495582900224 |
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| author | Hongfu Zhou Wenjing Xie Anran Guo Bin Chen Sanming Hu Min Zheng Houqiang Yu Hongan Tian Ling Li |
| author_facet | Hongfu Zhou Wenjing Xie Anran Guo Bin Chen Sanming Hu Min Zheng Houqiang Yu Hongan Tian Ling Li |
| author_sort | Hongfu Zhou |
| collection | DOAJ |
| description | Several vascular embolization materials are commonly used in clinical practice, however, having application defects of varying degrees, such as poor intraoperative imaging and easy recanalization of embolized blood vessels, they are challenging for application during Transcatheter arterial embolization (TAE). Thus, an intraoperative visible vascular embolization material with good embolization effect and biocompatibility can improve transcatheter arterial embolization clinical efficacy to some extent. Our study aimed to synthesize a novel vascular embolization material that can achieve complete embolization of arterial trunks and peripheral vessels, namely poly (N-isopropyl acrylamide)-co-acrylic acid nanogel (NIPAM-co-AA). Iohexol 200 mg/mL was co-assembled with 7 wt% NIPAM-co-AA nanogel to create an intelligent thermosensitive radiopaque nanogel (INCA), which achieves a good intraoperative imaging effect and is convenient for transcatheter arterial bolus injection due to its good fluidity and temperature-sensitive sol-gel phase transition. The normal rabbit kidney embolism model further confirmed that INCA could effectively use Digital subtraction angiography (DSA) to achieve intraoperative imaging, and real-time monitoring of the embolization process could avoid mis-embolization and leakage. Meanwhile, in a 42-day study, INCA demonstrated an excellent embolization effect on the right renal artery of New Zealand white rabbits, with no vascular recanalization and ischemic necrosis and calcification remaining. As a result, this radiopaque thermosensitive nanogel has the potential to be an intelligent thermosensitive medical vascular embolization material, providing dual benefits in TAE intraoperative imaging and long-term postoperative embolization while effectively addressing the shortcomings and challenges of commonly used clinical vascular embolization agents. |
| first_indexed | 2024-03-08T23:47:22Z |
| format | Article |
| id | doaj.art-153c93c3b6b342c18cca3d7007ade8c8 |
| institution | Directory Open Access Journal |
| issn | 1385-772X 1568-5551 |
| language | English |
| last_indexed | 2024-03-08T23:47:22Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Designed Monomers and Polymers |
| spelling | doaj.art-153c93c3b6b342c18cca3d7007ade8c82023-12-13T15:41:09ZengTaylor & Francis GroupDesigned Monomers and Polymers1385-772X1568-55512023-12-01261314410.1080/15685551.2022.21644452164445Temperature sensitive nanogels for real-time imaging during transcatheter arterial embolizationHongfu Zhou0Wenjing Xie1Anran Guo2Bin Chen3Sanming Hu4Min Zheng5Houqiang Yu6Hongan Tian7Ling Li8Xianning Medical College, Hubei University of Science and TechnologyXianning Medical College, Hubei University of Science and TechnologyXianning Medical College, Hubei University of Science and TechnologyXianning Central Hospital, the First Affiliated Hospital of Hubei University of Science and TechnologyXianning Medical College, Hubei University of Science and TechnologyXianning Medical College, Hubei University of Science and TechnologyHubei University of Science and TechnologyXianning Central Hospital, the First Affiliated Hospital of Hubei University of Science and TechnologyXianning Medical College, Hubei University of Science and TechnologySeveral vascular embolization materials are commonly used in clinical practice, however, having application defects of varying degrees, such as poor intraoperative imaging and easy recanalization of embolized blood vessels, they are challenging for application during Transcatheter arterial embolization (TAE). Thus, an intraoperative visible vascular embolization material with good embolization effect and biocompatibility can improve transcatheter arterial embolization clinical efficacy to some extent. Our study aimed to synthesize a novel vascular embolization material that can achieve complete embolization of arterial trunks and peripheral vessels, namely poly (N-isopropyl acrylamide)-co-acrylic acid nanogel (NIPAM-co-AA). Iohexol 200 mg/mL was co-assembled with 7 wt% NIPAM-co-AA nanogel to create an intelligent thermosensitive radiopaque nanogel (INCA), which achieves a good intraoperative imaging effect and is convenient for transcatheter arterial bolus injection due to its good fluidity and temperature-sensitive sol-gel phase transition. The normal rabbit kidney embolism model further confirmed that INCA could effectively use Digital subtraction angiography (DSA) to achieve intraoperative imaging, and real-time monitoring of the embolization process could avoid mis-embolization and leakage. Meanwhile, in a 42-day study, INCA demonstrated an excellent embolization effect on the right renal artery of New Zealand white rabbits, with no vascular recanalization and ischemic necrosis and calcification remaining. As a result, this radiopaque thermosensitive nanogel has the potential to be an intelligent thermosensitive medical vascular embolization material, providing dual benefits in TAE intraoperative imaging and long-term postoperative embolization while effectively addressing the shortcomings and challenges of commonly used clinical vascular embolization agents.http://dx.doi.org/10.1080/15685551.2022.2164445embolizationx-ray visiblehigh-strength nanogelsreal-time imagingtemperature-sensitive |
| spellingShingle | Hongfu Zhou Wenjing Xie Anran Guo Bin Chen Sanming Hu Min Zheng Houqiang Yu Hongan Tian Ling Li Temperature sensitive nanogels for real-time imaging during transcatheter arterial embolization Designed Monomers and Polymers embolization x-ray visible high-strength nanogels real-time imaging temperature-sensitive |
| title | Temperature sensitive nanogels for real-time imaging during transcatheter arterial embolization |
| title_full | Temperature sensitive nanogels for real-time imaging during transcatheter arterial embolization |
| title_fullStr | Temperature sensitive nanogels for real-time imaging during transcatheter arterial embolization |
| title_full_unstemmed | Temperature sensitive nanogels for real-time imaging during transcatheter arterial embolization |
| title_short | Temperature sensitive nanogels for real-time imaging during transcatheter arterial embolization |
| title_sort | temperature sensitive nanogels for real time imaging during transcatheter arterial embolization |
| topic | embolization x-ray visible high-strength nanogels real-time imaging temperature-sensitive |
| url | http://dx.doi.org/10.1080/15685551.2022.2164445 |
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