Indomethacin-induced gastric ulceration in rats: Protective roles of Spondias mombin and Ficus exasperata
This study investigated the quantitative polyphenolic constituents and gastroprotective effects of aqueous leaf extracts of Spondias mombin and Ficus exasperata against indomethacin-induced gastric ulcer in rats. Ulceration was induced by a single oral administration of indomethacin (30 mg/kg body w...
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| Format: | Article |
| Language: | English |
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Elsevier
2015-01-01
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| Series: | Toxicology Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214750015000037 |
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| author | Saheed Sabiu Taofeeq Garuba Taofik Sunmonu Emmanuel Ajani Abdulhakeem Sulyman Ismaila Nurain Abdulazeez Balogun |
| author_facet | Saheed Sabiu Taofeeq Garuba Taofik Sunmonu Emmanuel Ajani Abdulhakeem Sulyman Ismaila Nurain Abdulazeez Balogun |
| author_sort | Saheed Sabiu |
| collection | DOAJ |
| description | This study investigated the quantitative polyphenolic constituents and gastroprotective effects of aqueous leaf extracts of Spondias mombin and Ficus exasperata against indomethacin-induced gastric ulcer in rats. Ulceration was induced by a single oral administration of indomethacin (30 mg/kg body weight). Wistar rats were pretreated with esomeprazole (reference drug) at a dose of 20 mg/kg body weight, S. mombin or F. exasperata at 100 and 200 mg/kg body weight once daily for 21 days prior to ulcer induction. At the end of the experiment, gastric secretions and antioxidant parameters were evaluated. We observed that the significantly increased (p < 0.05) ulcer index, gastric volume, malondialdehyde level and pepsin activity were effectively reduced following treatment with S. mombin and F. exasperata. The extracts also markedly attenuated the reduced activity of superoxide dismutase as well as pH and mucin content in the ulcerated rats. These findings are indicative of gastroprotective and antioxidative potentials of the extracts which is also evident in the degree of % inhibition against ulceration. The available data in this study suggest that the extracts of S. mombin and F. exasperata proved to be capable of ameliorating indomethacin-induced gastric ulceration and the probable mechanisms are via antioxidative and proton pump inhibition. |
| first_indexed | 2024-12-10T11:29:24Z |
| format | Article |
| id | doaj.art-153d5e2030ab41c7b31482b0a7e7a7e6 |
| institution | Directory Open Access Journal |
| issn | 2214-7500 |
| language | English |
| last_indexed | 2024-12-10T11:29:24Z |
| publishDate | 2015-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Toxicology Reports |
| spelling | doaj.art-153d5e2030ab41c7b31482b0a7e7a7e62022-12-22T01:50:38ZengElsevierToxicology Reports2214-75002015-01-012C26126710.1016/j.toxrep.2015.01.002Indomethacin-induced gastric ulceration in rats: Protective roles of Spondias mombin and Ficus exasperataSaheed Sabiu0Taofeeq Garuba1Taofik Sunmonu2Emmanuel Ajani3Abdulhakeem Sulyman4Ismaila Nurain5Abdulazeez Balogun6Phytomedicine, Food Factors and Toxicology Research Laboratory, Biochemistry Unit, Department of Biosciences and Biotechnology, Kwara State University, P.M.B. 1530, Ilorin, NigeriaDepartment of Plant Biology, University of Ilorin, Ilorin, NigeriaPhytomedicine and Plant Biochemistry Research Laboratory, Biochemistry Unit, Department of Biological Sciences, Al-Hikmah University, Ilorin, NigeriaPhytomedicine, Food Factors and Toxicology Research Laboratory, Biochemistry Unit, Department of Biosciences and Biotechnology, Kwara State University, P.M.B. 1530, Ilorin, NigeriaPhytomedicine, Food Factors and Toxicology Research Laboratory, Biochemistry Unit, Department of Biosciences and Biotechnology, Kwara State University, P.M.B. 1530, Ilorin, NigeriaPhytomedicine, Food Factors and Toxicology Research Laboratory, Biochemistry Unit, Department of Biosciences and Biotechnology, Kwara State University, P.M.B. 1530, Ilorin, NigeriaPhytomedicine and Plant Biochemistry Research Laboratory, Biochemistry Unit, Department of Biological Sciences, Al-Hikmah University, Ilorin, NigeriaThis study investigated the quantitative polyphenolic constituents and gastroprotective effects of aqueous leaf extracts of Spondias mombin and Ficus exasperata against indomethacin-induced gastric ulcer in rats. Ulceration was induced by a single oral administration of indomethacin (30 mg/kg body weight). Wistar rats were pretreated with esomeprazole (reference drug) at a dose of 20 mg/kg body weight, S. mombin or F. exasperata at 100 and 200 mg/kg body weight once daily for 21 days prior to ulcer induction. At the end of the experiment, gastric secretions and antioxidant parameters were evaluated. We observed that the significantly increased (p < 0.05) ulcer index, gastric volume, malondialdehyde level and pepsin activity were effectively reduced following treatment with S. mombin and F. exasperata. The extracts also markedly attenuated the reduced activity of superoxide dismutase as well as pH and mucin content in the ulcerated rats. These findings are indicative of gastroprotective and antioxidative potentials of the extracts which is also evident in the degree of % inhibition against ulceration. The available data in this study suggest that the extracts of S. mombin and F. exasperata proved to be capable of ameliorating indomethacin-induced gastric ulceration and the probable mechanisms are via antioxidative and proton pump inhibition.http://www.sciencedirect.com/science/article/pii/S2214750015000037AntacidAntioxidativeGastroprotectiveNSAIDSProton pump inhibitorVagotomy |
| spellingShingle | Saheed Sabiu Taofeeq Garuba Taofik Sunmonu Emmanuel Ajani Abdulhakeem Sulyman Ismaila Nurain Abdulazeez Balogun Indomethacin-induced gastric ulceration in rats: Protective roles of Spondias mombin and Ficus exasperata Toxicology Reports Antacid Antioxidative Gastroprotective NSAIDS Proton pump inhibitor Vagotomy |
| title | Indomethacin-induced gastric ulceration in rats: Protective roles of Spondias mombin and Ficus exasperata |
| title_full | Indomethacin-induced gastric ulceration in rats: Protective roles of Spondias mombin and Ficus exasperata |
| title_fullStr | Indomethacin-induced gastric ulceration in rats: Protective roles of Spondias mombin and Ficus exasperata |
| title_full_unstemmed | Indomethacin-induced gastric ulceration in rats: Protective roles of Spondias mombin and Ficus exasperata |
| title_short | Indomethacin-induced gastric ulceration in rats: Protective roles of Spondias mombin and Ficus exasperata |
| title_sort | indomethacin induced gastric ulceration in rats protective roles of spondias mombin and ficus exasperata |
| topic | Antacid Antioxidative Gastroprotective NSAIDS Proton pump inhibitor Vagotomy |
| url | http://www.sciencedirect.com/science/article/pii/S2214750015000037 |
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