Surgical treatment for thyrotoxic hypokalemic periodic paralysis: case report
<p>Abstract</p> <p>Thyrotoxic hypokalemic periodic paralysis (THPP) is a rare, potentially life-threatening endocrine emergency. It is characterized by recurrent muscle weakness and hypokalemia. Because many THPP patients do not have obvious symptoms and signs of hyperthyroidism, m...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2012-01-01
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| Series: | World Journal of Surgical Oncology |
| Subjects: | |
| Online Access: | http://www.wjso.com/content/10/1/21 |
| _version_ | 1819028493997965312 |
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| author | Lin Yi-Chu Wu Che-Wei Chen Hui-Chun Chen Hsiu-Ya Lu I-Cheng Tsai Cheng-Jing Kuo Wen-Rei Chiang Feng-Yu |
| author_facet | Lin Yi-Chu Wu Che-Wei Chen Hui-Chun Chen Hsiu-Ya Lu I-Cheng Tsai Cheng-Jing Kuo Wen-Rei Chiang Feng-Yu |
| author_sort | Lin Yi-Chu |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Thyrotoxic hypokalemic periodic paralysis (THPP) is a rare, potentially life-threatening endocrine emergency. It is characterized by recurrent muscle weakness and hypokalemia. Because many THPP patients do not have obvious symptoms and signs of hyperthyroidism, misdiagnosis may occur. The published studies revealed that definitive therapy for THPP is control of hyperthyroidism by medical therapy, radioactive iodine or surgery, but the long-term post-operative follow-up result was not observed. We reported two cases of medically refractory THPP with recurrent paralysis of extremities and hypokalemia, and both were combined with thyroid nodules. Both patients were treated with total thyroidectomy; the pathology revealed that one is Graves' disease with thyroid papillary carcinoma, and the other is adenomatous goiter with papillary hyperplasia. No episode of periodic paralysis was noted and laboratory evaluation revealed normal potassium level during the post-operative follow up. Our experience suggests that total thyroidectomy by experienced surgeon is an appropriate and definite treatment for medically refractory THPP, especially in cases combined with thyroid nodules.</p> |
| first_indexed | 2024-12-21T05:59:15Z |
| format | Article |
| id | doaj.art-153e9d0db3ba4916b3dc70c59c71b2fb |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-12-21T05:59:15Z |
| publishDate | 2012-01-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-153e9d0db3ba4916b3dc70c59c71b2fb2022-12-21T19:13:48ZengBMCWorld Journal of Surgical Oncology1477-78192012-01-011012110.1186/1477-7819-10-21Surgical treatment for thyrotoxic hypokalemic periodic paralysis: case reportLin Yi-ChuWu Che-WeiChen Hui-ChunChen Hsiu-YaLu I-ChengTsai Cheng-JingKuo Wen-ReiChiang Feng-Yu<p>Abstract</p> <p>Thyrotoxic hypokalemic periodic paralysis (THPP) is a rare, potentially life-threatening endocrine emergency. It is characterized by recurrent muscle weakness and hypokalemia. Because many THPP patients do not have obvious symptoms and signs of hyperthyroidism, misdiagnosis may occur. The published studies revealed that definitive therapy for THPP is control of hyperthyroidism by medical therapy, radioactive iodine or surgery, but the long-term post-operative follow-up result was not observed. We reported two cases of medically refractory THPP with recurrent paralysis of extremities and hypokalemia, and both were combined with thyroid nodules. Both patients were treated with total thyroidectomy; the pathology revealed that one is Graves' disease with thyroid papillary carcinoma, and the other is adenomatous goiter with papillary hyperplasia. No episode of periodic paralysis was noted and laboratory evaluation revealed normal potassium level during the post-operative follow up. Our experience suggests that total thyroidectomy by experienced surgeon is an appropriate and definite treatment for medically refractory THPP, especially in cases combined with thyroid nodules.</p>http://www.wjso.com/content/10/1/21thyrotoxic hypokalemic periodic paralysishypokalemic periodic paralysisthyrotoxicthyrotoxic periodic paralysisthyroidectomy |
| spellingShingle | Lin Yi-Chu Wu Che-Wei Chen Hui-Chun Chen Hsiu-Ya Lu I-Cheng Tsai Cheng-Jing Kuo Wen-Rei Chiang Feng-Yu Surgical treatment for thyrotoxic hypokalemic periodic paralysis: case report World Journal of Surgical Oncology thyrotoxic hypokalemic periodic paralysis hypokalemic periodic paralysis thyrotoxic thyrotoxic periodic paralysis thyroidectomy |
| title | Surgical treatment for thyrotoxic hypokalemic periodic paralysis: case report |
| title_full | Surgical treatment for thyrotoxic hypokalemic periodic paralysis: case report |
| title_fullStr | Surgical treatment for thyrotoxic hypokalemic periodic paralysis: case report |
| title_full_unstemmed | Surgical treatment for thyrotoxic hypokalemic periodic paralysis: case report |
| title_short | Surgical treatment for thyrotoxic hypokalemic periodic paralysis: case report |
| title_sort | surgical treatment for thyrotoxic hypokalemic periodic paralysis case report |
| topic | thyrotoxic hypokalemic periodic paralysis hypokalemic periodic paralysis thyrotoxic thyrotoxic periodic paralysis thyroidectomy |
| url | http://www.wjso.com/content/10/1/21 |
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