The role of MAPK11/12/13/14 (p38 MAPK) protein in dopamine agonist-resistant prolactinomas

The role of MAPK11/12/13/14 (p38 MAPK) protein in dopamine agonist-resistant prolactinomas

Abstract Background Prolactinoma is a functional pituitary adenoma that secretes excessive prolactin. Dopamine agonists (DAs) such as bromocriptine (BRC) are the first-line treatment for prolactinomas, but the resistance rate is increasing year by year, creating a clinical challenge. Therefore, it i...

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Bibliographic Details
Main Authors: Shuman Wang, Aihua Wang, Yu Zhang, Kejing Zhu, Xiong Wang, Yonggang Chen, Jinhu Wu
Format: Article
Language:English
Published: BMC 2021-11-01
Series:BMC Endocrine Disorders
Subjects:
Prolactinomas
Dopamine agonist
Bromocriptine
Drug resistance
MAPK11/12/13/14
Online Access:https://doi.org/10.1186/s12902-021-00900-9

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