Cell death induction in Aspergillus fumigatus: accentuating drug toxicity through inhibition of the unfolded protein response (UPR)
One of the most potent opportunistic fungal pathogens of humans is Aspergillus fumigatus, an environmental mold that causes a life-threatening pneumonia with a high rate of morbidity and mortality. Despite advances in therapy, issues of drug toxicity and antifungal resistance remain an obstacle to e...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-01-01
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| Series: | Current Research in Microbial Sciences |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666517422000165 |
| _version_ | 1811202145609842688 |
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| author | José P. Guirao-Abad Martin Weichert David S. Askew |
| author_facet | José P. Guirao-Abad Martin Weichert David S. Askew |
| author_sort | José P. Guirao-Abad |
| collection | DOAJ |
| description | One of the most potent opportunistic fungal pathogens of humans is Aspergillus fumigatus, an environmental mold that causes a life-threatening pneumonia with a high rate of morbidity and mortality. Despite advances in therapy, issues of drug toxicity and antifungal resistance remain an obstacle to effective therapy. This underscores the need for more information on fungal pathways that could be pharmacologically manipulated to either reduce the viability of the fungus during infection, or to unleash the fungicidal potential of current antifungal drugs. In this review, we summarize the emerging evidence that the ability of A. fumigatus to sustain viability during stress relies heavily on an adaptive signaling pathway known as the unfolded protein response (UPR), thereby exposing a vulnerability in this fungus that has strong potential for future therapeutic intervention. |
| first_indexed | 2024-04-12T02:35:04Z |
| format | Article |
| id | doaj.art-153fec2477c84a678df67f2e83f970ca |
| institution | Directory Open Access Journal |
| issn | 2666-5174 |
| language | English |
| last_indexed | 2024-04-12T02:35:04Z |
| publishDate | 2022-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Microbial Sciences |
| spelling | doaj.art-153fec2477c84a678df67f2e83f970ca2022-12-22T03:51:36ZengElsevierCurrent Research in Microbial Sciences2666-51742022-01-013100119Cell death induction in Aspergillus fumigatus: accentuating drug toxicity through inhibition of the unfolded protein response (UPR)José P. Guirao-Abad0Martin Weichert1David S. Askew2Department of Pathology & Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USADepartment of Pathology & Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USACorresponding author.; Department of Pathology & Laboratory Medicine, University of Cincinnati College of Medicine, Cincinnati, OH, USAOne of the most potent opportunistic fungal pathogens of humans is Aspergillus fumigatus, an environmental mold that causes a life-threatening pneumonia with a high rate of morbidity and mortality. Despite advances in therapy, issues of drug toxicity and antifungal resistance remain an obstacle to effective therapy. This underscores the need for more information on fungal pathways that could be pharmacologically manipulated to either reduce the viability of the fungus during infection, or to unleash the fungicidal potential of current antifungal drugs. In this review, we summarize the emerging evidence that the ability of A. fumigatus to sustain viability during stress relies heavily on an adaptive signaling pathway known as the unfolded protein response (UPR), thereby exposing a vulnerability in this fungus that has strong potential for future therapeutic intervention.http://www.sciencedirect.com/science/article/pii/S2666517422000165Aspergillus fumigatusUPRHacAIreAER stresscell death |
| spellingShingle | José P. Guirao-Abad Martin Weichert David S. Askew Cell death induction in Aspergillus fumigatus: accentuating drug toxicity through inhibition of the unfolded protein response (UPR) Current Research in Microbial Sciences Aspergillus fumigatus UPR HacA IreA ER stress cell death |
| title | Cell death induction in Aspergillus fumigatus: accentuating drug toxicity through inhibition of the unfolded protein response (UPR) |
| title_full | Cell death induction in Aspergillus fumigatus: accentuating drug toxicity through inhibition of the unfolded protein response (UPR) |
| title_fullStr | Cell death induction in Aspergillus fumigatus: accentuating drug toxicity through inhibition of the unfolded protein response (UPR) |
| title_full_unstemmed | Cell death induction in Aspergillus fumigatus: accentuating drug toxicity through inhibition of the unfolded protein response (UPR) |
| title_short | Cell death induction in Aspergillus fumigatus: accentuating drug toxicity through inhibition of the unfolded protein response (UPR) |
| title_sort | cell death induction in aspergillus fumigatus accentuating drug toxicity through inhibition of the unfolded protein response upr |
| topic | Aspergillus fumigatus UPR HacA IreA ER stress cell death |
| url | http://www.sciencedirect.com/science/article/pii/S2666517422000165 |
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