Cell death induction in Aspergillus fumigatus: accentuating drug toxicity through inhibition of the unfolded protein response (UPR)

Cell death induction in Aspergillus fumigatus: accentuating drug toxicity through inhibition of the unfolded protein response (UPR)

One of the most potent opportunistic fungal pathogens of humans is Aspergillus fumigatus, an environmental mold that causes a life-threatening pneumonia with a high rate of morbidity and mortality. Despite advances in therapy, issues of drug toxicity and antifungal resistance remain an obstacle to e...

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Bibliographic Details
Main Authors: José P. Guirao-Abad, Martin Weichert, David S. Askew
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:Current Research in Microbial Sciences
Subjects:
Aspergillus fumigatus
UPR
HacA
IreA
ER stress
cell death
Online Access:http://www.sciencedirect.com/science/article/pii/S2666517422000165

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