Spinacia oleracea retards the development of Amygdala kindled epilepsy in rats
The protective role of Spinacia oleracea (SO) has been evaluated against the development of Amygdala kindled (AMK) experimental epileptogenesis. Thirty six Holtzman strain adult male albino rats (200-250 g) were equally divided into 1) control, 2) SO, 3) AMK, 4) SO+AMK, 5) DZ+AMK group. After discha...
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| Format: | Article |
| Language: | English |
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Al Ameen Medical College
2011-04-01
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| Series: | Al Ameen Journal of Medical Sciences |
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| Online Access: | http://ajms.alameenmedical.org/article_Vol04-2-apr-jun-2011/AJMS.4.2.2011%20p%20175-190.pdf |
| _version_ | 1818033565872422912 |
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| author | Sutapa Das and Debjani Guha* |
| author_facet | Sutapa Das and Debjani Guha* |
| author_sort | Sutapa Das and Debjani Guha* |
| collection | DOAJ |
| description | The protective role of Spinacia oleracea (SO) has been evaluated against the development of Amygdala kindled (AMK) experimental epileptogenesis. Thirty six Holtzman strain adult male albino rats (200-250 g) were equally divided into 1) control, 2) SO, 3) AMK, 4) SO+AMK, 5) DZ+AMK group. After discharge duration (ADD) were used as indices of kindled seizures. In AMK group, seizure stages reached upto stage 4–5 within the second week. EEG tracings showed that pretreatment with SO in AMK group decreased the ADD and seizure stages of SO pretreated rats were limited within stage 1–2 from 1st to 4th week of kindling. Brain monoamine content of Serotonin (5-HT) was decreased in cerebral cortex (CC), cerebellum (CB), caudate nucleus (CN), midbrain (MB) and pons-medulla (PM) of AMK group which was increased by SO pre-treatment. Alteration of Dopamine (DA) and Norepinephrine (NE) in different brain regions of AMK group was also modulated by SO pre-treatment. Thus SO pre-treatment retards the development of amygdala kindled epilepsy in experimental animals by modulating behavioural and neurochemical aspects |
| first_indexed | 2024-12-10T06:25:18Z |
| format | Article |
| id | doaj.art-1540455ef0594639beefd75904d548dd |
| institution | Directory Open Access Journal |
| issn | 0974-1143 |
| language | English |
| last_indexed | 2024-12-10T06:25:18Z |
| publishDate | 2011-04-01 |
| publisher | Al Ameen Medical College |
| record_format | Article |
| series | Al Ameen Journal of Medical Sciences |
| spelling | doaj.art-1540455ef0594639beefd75904d548dd2022-12-22T01:59:14ZengAl Ameen Medical CollegeAl Ameen Journal of Medical Sciences0974-11432011-04-010402175190Spinacia oleracea retards the development of Amygdala kindled epilepsy in ratsSutapa Das and Debjani Guha*The protective role of Spinacia oleracea (SO) has been evaluated against the development of Amygdala kindled (AMK) experimental epileptogenesis. Thirty six Holtzman strain adult male albino rats (200-250 g) were equally divided into 1) control, 2) SO, 3) AMK, 4) SO+AMK, 5) DZ+AMK group. After discharge duration (ADD) were used as indices of kindled seizures. In AMK group, seizure stages reached upto stage 4–5 within the second week. EEG tracings showed that pretreatment with SO in AMK group decreased the ADD and seizure stages of SO pretreated rats were limited within stage 1–2 from 1st to 4th week of kindling. Brain monoamine content of Serotonin (5-HT) was decreased in cerebral cortex (CC), cerebellum (CB), caudate nucleus (CN), midbrain (MB) and pons-medulla (PM) of AMK group which was increased by SO pre-treatment. Alteration of Dopamine (DA) and Norepinephrine (NE) in different brain regions of AMK group was also modulated by SO pre-treatment. Thus SO pre-treatment retards the development of amygdala kindled epilepsy in experimental animals by modulating behavioural and neurochemical aspectshttp://ajms.alameenmedical.org/article_Vol04-2-apr-jun-2011/AJMS.4.2.2011%20p%20175-190.pdfAmygdala kindlingADDEEGBrain monoamines |
| spellingShingle | Sutapa Das and Debjani Guha* Spinacia oleracea retards the development of Amygdala kindled epilepsy in rats Al Ameen Journal of Medical Sciences Amygdala kindling ADD EEG Brain monoamines |
| title | Spinacia oleracea retards the development of Amygdala kindled epilepsy in rats |
| title_full | Spinacia oleracea retards the development of Amygdala kindled epilepsy in rats |
| title_fullStr | Spinacia oleracea retards the development of Amygdala kindled epilepsy in rats |
| title_full_unstemmed | Spinacia oleracea retards the development of Amygdala kindled epilepsy in rats |
| title_short | Spinacia oleracea retards the development of Amygdala kindled epilepsy in rats |
| title_sort | spinacia oleracea retards the development of amygdala kindled epilepsy in rats |
| topic | Amygdala kindling ADD EEG Brain monoamines |
| url | http://ajms.alameenmedical.org/article_Vol04-2-apr-jun-2011/AJMS.4.2.2011%20p%20175-190.pdf |
| work_keys_str_mv | AT sutapadasanddebjaniguha spinaciaoleracearetardsthedevelopmentofamygdalakindledepilepsyinrats |