Standard therapies: solutions for improving therapeutic effects of immune checkpoint inhibitors on colorectal cancer
Immunotherapy using immune checkpoint inhibitors has opened a new era for cancer management. In colorectal cancer, patients with a phenotype of deficient mismatch repair or high microsatellite instability benefit from immunotherapy. However, the response of rest cases to immunotherapy alone is still...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Taylor & Francis Group
2020-01-01
|
| Series: | OncoImmunology |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/2162402X.2020.1773205 |
| _version_ | 1831667742288117760 |
|---|---|
| author | Tingting Liang Weihua Tong Siyang Ma Pengyu Chang |
| author_facet | Tingting Liang Weihua Tong Siyang Ma Pengyu Chang |
| author_sort | Tingting Liang |
| collection | DOAJ |
| description | Immunotherapy using immune checkpoint inhibitors has opened a new era for cancer management. In colorectal cancer, patients with a phenotype of deficient mismatch repair or high microsatellite instability benefit from immunotherapy. However, the response of rest cases to immunotherapy alone is still poor. Nevertheless, preclinical data have revealed that either ionizing irradiation or chemotherapy can improve the tumoral immune milieu, because these approaches can induce immunogenic cell death among cancer cells. In this regard, combination use of standard therapy plus immunotherapy should be feasible. In this review, we will introduce the specific roles of standard therapies, including radiotherapy, chemotherapy, antiangiogenic and anti-EGFR therapy, in improving therapeutic effect of immune checkpoint inhibitors on colorectal cancer. |
| first_indexed | 2024-12-19T20:17:08Z |
| format | Article |
| id | doaj.art-154084074d8c4e10a5be5f2432f489b9 |
| institution | Directory Open Access Journal |
| issn | 2162-402X |
| language | English |
| last_indexed | 2024-12-19T20:17:08Z |
| publishDate | 2020-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | OncoImmunology |
| spelling | doaj.art-154084074d8c4e10a5be5f2432f489b92022-12-21T20:07:07ZengTaylor & Francis GroupOncoImmunology2162-402X2020-01-019110.1080/2162402X.2020.17732051773205Standard therapies: solutions for improving therapeutic effects of immune checkpoint inhibitors on colorectal cancerTingting Liang0Weihua Tong1Siyang Ma2Pengyu Chang3The First Hospital of Jilin UniversityThe First Hospital of Jilin UniversityThe First Hospital of Jilin UniversityThe First Hospital of Jilin UniversityImmunotherapy using immune checkpoint inhibitors has opened a new era for cancer management. In colorectal cancer, patients with a phenotype of deficient mismatch repair or high microsatellite instability benefit from immunotherapy. However, the response of rest cases to immunotherapy alone is still poor. Nevertheless, preclinical data have revealed that either ionizing irradiation or chemotherapy can improve the tumoral immune milieu, because these approaches can induce immunogenic cell death among cancer cells. In this regard, combination use of standard therapy plus immunotherapy should be feasible. In this review, we will introduce the specific roles of standard therapies, including radiotherapy, chemotherapy, antiangiogenic and anti-EGFR therapy, in improving therapeutic effect of immune checkpoint inhibitors on colorectal cancer.http://dx.doi.org/10.1080/2162402X.2020.1773205colorectal cancerradiotherapychemotherapymolecule-targeted drugimmune checkpoint inhibitor |
| spellingShingle | Tingting Liang Weihua Tong Siyang Ma Pengyu Chang Standard therapies: solutions for improving therapeutic effects of immune checkpoint inhibitors on colorectal cancer OncoImmunology colorectal cancer radiotherapy chemotherapy molecule-targeted drug immune checkpoint inhibitor |
| title | Standard therapies: solutions for improving therapeutic effects of immune checkpoint inhibitors on colorectal cancer |
| title_full | Standard therapies: solutions for improving therapeutic effects of immune checkpoint inhibitors on colorectal cancer |
| title_fullStr | Standard therapies: solutions for improving therapeutic effects of immune checkpoint inhibitors on colorectal cancer |
| title_full_unstemmed | Standard therapies: solutions for improving therapeutic effects of immune checkpoint inhibitors on colorectal cancer |
| title_short | Standard therapies: solutions for improving therapeutic effects of immune checkpoint inhibitors on colorectal cancer |
| title_sort | standard therapies solutions for improving therapeutic effects of immune checkpoint inhibitors on colorectal cancer |
| topic | colorectal cancer radiotherapy chemotherapy molecule-targeted drug immune checkpoint inhibitor |
| url | http://dx.doi.org/10.1080/2162402X.2020.1773205 |
| work_keys_str_mv | AT tingtingliang standardtherapiessolutionsforimprovingtherapeuticeffectsofimmunecheckpointinhibitorsoncolorectalcancer AT weihuatong standardtherapiessolutionsforimprovingtherapeuticeffectsofimmunecheckpointinhibitorsoncolorectalcancer AT siyangma standardtherapiessolutionsforimprovingtherapeuticeffectsofimmunecheckpointinhibitorsoncolorectalcancer AT pengyuchang standardtherapiessolutionsforimprovingtherapeuticeffectsofimmunecheckpointinhibitorsoncolorectalcancer |