Outcomes of Conbercept therapy for choroidal neovascularization secondary to pathological myopia
AIM: To evaluate the one-year outcome of intravitreal conbercept injections for the treatment of choroidal neovascularization secondary to pathological myopia(pm-CNV)by optical coherence tomography angiography(OCTA).<p>METHODS: The medical records of 26 consecutive eyes of 23 patients who rece...
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| Language: | English |
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Press of International Journal of Ophthalmology (IJO PRESS)
2020-12-01
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| Series: | Guoji Yanke Zazhi |
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| Online Access: | http://ies.ijo.cn/cn_publish/2020/12/202012001.pdf |
| _version_ | 1819093644693471232 |
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| author | Zheng-Feng Liu Xue-Mei Pan Da-Dong Guo Mei-Hua Ding Hong-Sheng Bi |
| author_facet | Zheng-Feng Liu Xue-Mei Pan Da-Dong Guo Mei-Hua Ding Hong-Sheng Bi |
| author_sort | Zheng-Feng Liu |
| collection | DOAJ |
| description | AIM: To evaluate the one-year outcome of intravitreal conbercept injections for the treatment of choroidal neovascularization secondary to pathological myopia(pm-CNV)by optical coherence tomography angiography(OCTA).<p>METHODS: The medical records of 26 consecutive eyes of 23 patients who received intravitreal injections of conbercept for pm-CNV with a follow-up of 1y were retrospectively reviewed. All the patients were diagnosed by fundus fluorescein angiography(FFA)and OCTA at the first visit. All approaches were performed as “1+PRN” treatment. Outcomes included best-corrected visual acuity(BCVA), central foveal thickness(CFT)and the mean CNV area by OCTA.<p>RESULTS: Mean BCVA improved from(0.66±0.51)at baseline to(0.39±0.38)at 1y(<i>t</i>=3.528, <i>P</i>=0.004). The CFT before treatment and after 1y after were(275.08±48.74)μm and(205.15±43.74)μm respectively(<i>t</i>=4.630, <i>P</i>=0.001). The mean pm-CNV areas before treatment and after 1y treatment were(0.48±0.24)mm<sup>2</sup> and(0.15±0.11)mm<sup>2</sup> respectively, with a significant difference among them(<i>t</i>=5.329, <i>P</i>=0.000). Twenty-one eyes had no needs after the first treatment. Four eyes received 2 injections and only one eye received 3 injections. No severe adverse events were noted relevant to the therapy.<p>CONCLUSION: Intravitreal conbercept can improve the vision and relieve CFT and CNV area for the treatment of pm-CNV with “1+PRN” by OCTA for 1y, however, long-term follow-up still need to be performed. |
| first_indexed | 2024-12-21T23:14:48Z |
| format | Article |
| id | doaj.art-1540c7e4ac014e4894e9d70baab15888 |
| institution | Directory Open Access Journal |
| issn | 1672-5123 1672-5123 |
| language | English |
| last_indexed | 2024-12-21T23:14:48Z |
| publishDate | 2020-12-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
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| series | Guoji Yanke Zazhi |
| spelling | doaj.art-1540c7e4ac014e4894e9d70baab158882022-12-21T18:46:56ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51231672-51232020-12-0120122019202210.3980/j.issn.1672-5123.2020.12.01Outcomes of Conbercept therapy for choroidal neovascularization secondary to pathological myopiaZheng-Feng Liu0Xue-Mei Pan1Da-Dong Guo2Mei-Hua Ding3Hong-Sheng Bi4Shandong University of Traditional Chinese Medicine, Jinan 250355, Shandong Province, ChinaAffiliated Eye Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250002, Shandong Province, ChinaEye Institute of Shandong University of Traditional Chinese Medicine, Jinan 250002, Shandong Province, ChinaAffiliated Eye Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250002, Shandong Province, ChinaAffiliated Eye Hospital of Shandong University of Traditional Chinese Medicine, Jinan 250002, Shandong Province, China; Eye Institute of Shandong University of Traditional Chinese Medicine, Jinan 250002, Shandong Province, ChinaAIM: To evaluate the one-year outcome of intravitreal conbercept injections for the treatment of choroidal neovascularization secondary to pathological myopia(pm-CNV)by optical coherence tomography angiography(OCTA).<p>METHODS: The medical records of 26 consecutive eyes of 23 patients who received intravitreal injections of conbercept for pm-CNV with a follow-up of 1y were retrospectively reviewed. All the patients were diagnosed by fundus fluorescein angiography(FFA)and OCTA at the first visit. All approaches were performed as “1+PRN” treatment. Outcomes included best-corrected visual acuity(BCVA), central foveal thickness(CFT)and the mean CNV area by OCTA.<p>RESULTS: Mean BCVA improved from(0.66±0.51)at baseline to(0.39±0.38)at 1y(<i>t</i>=3.528, <i>P</i>=0.004). The CFT before treatment and after 1y after were(275.08±48.74)μm and(205.15±43.74)μm respectively(<i>t</i>=4.630, <i>P</i>=0.001). The mean pm-CNV areas before treatment and after 1y treatment were(0.48±0.24)mm<sup>2</sup> and(0.15±0.11)mm<sup>2</sup> respectively, with a significant difference among them(<i>t</i>=5.329, <i>P</i>=0.000). Twenty-one eyes had no needs after the first treatment. Four eyes received 2 injections and only one eye received 3 injections. No severe adverse events were noted relevant to the therapy.<p>CONCLUSION: Intravitreal conbercept can improve the vision and relieve CFT and CNV area for the treatment of pm-CNV with “1+PRN” by OCTA for 1y, however, long-term follow-up still need to be performed.http://ies.ijo.cn/cn_publish/2020/12/202012001.pdfchoroidal neovascularization secondary to pathological myopia; conbercept; optical coherence tomography angiography; curative effectchoroidal neovascularization secondary to pathological myopiaconberceptoptical coherence tomography angiographycurative effect |
| spellingShingle | Zheng-Feng Liu Xue-Mei Pan Da-Dong Guo Mei-Hua Ding Hong-Sheng Bi Outcomes of Conbercept therapy for choroidal neovascularization secondary to pathological myopia Guoji Yanke Zazhi choroidal neovascularization secondary to pathological myopia; conbercept; optical coherence tomography angiography; curative effect choroidal neovascularization secondary to pathological myopia conbercept optical coherence tomography angiography curative effect |
| title | Outcomes of Conbercept therapy for choroidal neovascularization secondary to pathological myopia |
| title_full | Outcomes of Conbercept therapy for choroidal neovascularization secondary to pathological myopia |
| title_fullStr | Outcomes of Conbercept therapy for choroidal neovascularization secondary to pathological myopia |
| title_full_unstemmed | Outcomes of Conbercept therapy for choroidal neovascularization secondary to pathological myopia |
| title_short | Outcomes of Conbercept therapy for choroidal neovascularization secondary to pathological myopia |
| title_sort | outcomes of conbercept therapy for choroidal neovascularization secondary to pathological myopia |
| topic | choroidal neovascularization secondary to pathological myopia; conbercept; optical coherence tomography angiography; curative effect choroidal neovascularization secondary to pathological myopia conbercept optical coherence tomography angiography curative effect |
| url | http://ies.ijo.cn/cn_publish/2020/12/202012001.pdf |
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