Updated Evaluation of Dupilumab in the Treatment of Asthma: Patient Selection and Reported Outcomes
G Daniel Brooks The Asthma and Allergy Center, Bellevue, NE, USACorrespondence: G Daniel BrooksThe Asthma and Allergy Center, 3503 Samson Way, Suite 108, Bellevue, NE 68123, USATel +1-402-592-2055Fax +1-402-592-2419Email gdbrooks@asthmaandallergycenter.comAbstract: Uncontrolled asthma continues to b...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2020-03-01
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| Series: | Therapeutics and Clinical Risk Management |
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| Online Access: | https://www.dovepress.com/updated-evaluation-of-dupilumab-in-the-treatment-of-asthma-patient-sel-peer-reviewed-article-TCRM |
| _version_ | 1818852030623514624 |
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| author | Brooks GD |
| author_facet | Brooks GD |
| author_sort | Brooks GD |
| collection | DOAJ |
| description | G Daniel Brooks The Asthma and Allergy Center, Bellevue, NE, USACorrespondence: G Daniel BrooksThe Asthma and Allergy Center, 3503 Samson Way, Suite 108, Bellevue, NE 68123, USATel +1-402-592-2055Fax +1-402-592-2419Email gdbrooks@asthmaandallergycenter.comAbstract: Uncontrolled asthma continues to be a problem for many patients with moderate-to-severe allergic asthma. Dupilumab, which blocks the receptors for interleukin-4 and interleukin-13, has been effective in reducing asthma exacerbations, improving forced expiratory volume in one second (FEV1), and reducing oral corticosteroid use. When selecting patients for dupilumab, it is important to consider entry criteria for the original studies, subgroups that have responded best, and the presence of comorbid diseases that may also respond to dupilumab. Factors that were considered when selecting patients likely to respond to dupilumab in asthma studies include: failure of moderate or high dose inhaled steroids in combination with an additional controller medication, baseline FEV1 reversibility of 12% or greater, and Asthma Control Questionnaire > 1.5. The baseline characteristics that predicted a better response to dupilumab included blood eosinophils > 150 cells/mm3 and fractional exhaled nitric oxide > 25 parts per billion. Comorbidities that may also respond to treatment with dupilumab include atopic dermatitis, chronic rhinosinusitis, and allergic rhinitis. A combination of these factors should be considered when selecting the patients most likely to benefit from dupilumab.Keywords: allergic asthma, dupilumab, eosinophils, nitric oxide, comorbidity |
| first_indexed | 2024-12-19T07:14:26Z |
| format | Article |
| id | doaj.art-15454419d7904ee6b5f4dbc3c7fab253 |
| institution | Directory Open Access Journal |
| issn | 1178-203X |
| language | English |
| last_indexed | 2024-12-19T07:14:26Z |
| publishDate | 2020-03-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Therapeutics and Clinical Risk Management |
| spelling | doaj.art-15454419d7904ee6b5f4dbc3c7fab2532022-12-21T20:31:07ZengDove Medical PressTherapeutics and Clinical Risk Management1178-203X2020-03-01Volume 1618118752258Updated Evaluation of Dupilumab in the Treatment of Asthma: Patient Selection and Reported OutcomesBrooks GDG Daniel Brooks The Asthma and Allergy Center, Bellevue, NE, USACorrespondence: G Daniel BrooksThe Asthma and Allergy Center, 3503 Samson Way, Suite 108, Bellevue, NE 68123, USATel +1-402-592-2055Fax +1-402-592-2419Email gdbrooks@asthmaandallergycenter.comAbstract: Uncontrolled asthma continues to be a problem for many patients with moderate-to-severe allergic asthma. Dupilumab, which blocks the receptors for interleukin-4 and interleukin-13, has been effective in reducing asthma exacerbations, improving forced expiratory volume in one second (FEV1), and reducing oral corticosteroid use. When selecting patients for dupilumab, it is important to consider entry criteria for the original studies, subgroups that have responded best, and the presence of comorbid diseases that may also respond to dupilumab. Factors that were considered when selecting patients likely to respond to dupilumab in asthma studies include: failure of moderate or high dose inhaled steroids in combination with an additional controller medication, baseline FEV1 reversibility of 12% or greater, and Asthma Control Questionnaire > 1.5. The baseline characteristics that predicted a better response to dupilumab included blood eosinophils > 150 cells/mm3 and fractional exhaled nitric oxide > 25 parts per billion. Comorbidities that may also respond to treatment with dupilumab include atopic dermatitis, chronic rhinosinusitis, and allergic rhinitis. A combination of these factors should be considered when selecting the patients most likely to benefit from dupilumab.Keywords: allergic asthma, dupilumab, eosinophils, nitric oxide, comorbidityhttps://www.dovepress.com/updated-evaluation-of-dupilumab-in-the-treatment-of-asthma-patient-sel-peer-reviewed-article-TCRMallergic asthmadupilumabeosinophilsnitric oxidecomorbidity |
| spellingShingle | Brooks GD Updated Evaluation of Dupilumab in the Treatment of Asthma: Patient Selection and Reported Outcomes Therapeutics and Clinical Risk Management allergic asthma dupilumab eosinophils nitric oxide comorbidity |
| title | Updated Evaluation of Dupilumab in the Treatment of Asthma: Patient Selection and Reported Outcomes |
| title_full | Updated Evaluation of Dupilumab in the Treatment of Asthma: Patient Selection and Reported Outcomes |
| title_fullStr | Updated Evaluation of Dupilumab in the Treatment of Asthma: Patient Selection and Reported Outcomes |
| title_full_unstemmed | Updated Evaluation of Dupilumab in the Treatment of Asthma: Patient Selection and Reported Outcomes |
| title_short | Updated Evaluation of Dupilumab in the Treatment of Asthma: Patient Selection and Reported Outcomes |
| title_sort | updated evaluation of dupilumab in the treatment of asthma patient selection and reported outcomes |
| topic | allergic asthma dupilumab eosinophils nitric oxide comorbidity |
| url | https://www.dovepress.com/updated-evaluation-of-dupilumab-in-the-treatment-of-asthma-patient-sel-peer-reviewed-article-TCRM |
| work_keys_str_mv | AT brooksgd updatedevaluationofdupilumabinthetreatmentofasthmapatientselectionandreportedoutcomes |