Use of GMI‐1271, an E‐selectin antagonist, in healthy subjects and in 2 patients with calf vein thrombosis

Use of GMI‐1271, an E‐selectin antagonist, in healthy subjects and in 2 patients with calf vein thrombosis

Abstract Background There is an unmet need for antithrombotic treatments for venous thromboembolic disease that do not increase bleeding risk. Selectins are cell adhesion molecules that augment thrombosis by activating immune cells to initiate the coagulation cascade. GMI‐1271, a potent small‐molecu...

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Bibliographic Details
Main Authors: Sumana Devata, Dana E. Angelini, Susan Blackburn, Angela Hawley, Daniel D. Myers, Jordan K. Schaefer, Martina Hemmer, John L. Magnani, Helen M. Thackray, Thomas W. Wakefield, Suman L. Sood
Format: Article
Language:English
Published: Elsevier 2020-02-01
Series:Research and Practice in Thrombosis and Haemostasis
Subjects:
biomarkers
deep vein thrombosis
E‐selectin
therapeutics
venous thromboembolism
Online Access:https://doi.org/10.1002/rth2.12279

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