Tadalafil and Steroid Hormones Interactions in Adipose, Bone and Prostate Tissues: Focus on Translational Perspectives
Tadalafil is a selective phosphodiesterase type-5 (PDE5) inhibitor that is approved for the treatment of men with erectile dysfunction (ED) and/or benign prostate hyperplasia (BPH) -associated symptoms. Besides its classical actions on PDE5 within the genitourinary tract, where the specific enzyme e...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-04-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/23/8/4191 |
| _version_ | 1797445923499933696 |
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| author | Emanuela Alessandra Greco Cristina Antinozzi Luigi Di Luigi Antonio Aversa Paolo Sgrò |
| author_facet | Emanuela Alessandra Greco Cristina Antinozzi Luigi Di Luigi Antonio Aversa Paolo Sgrò |
| author_sort | Emanuela Alessandra Greco |
| collection | DOAJ |
| description | Tadalafil is a selective phosphodiesterase type-5 (PDE5) inhibitor that is approved for the treatment of men with erectile dysfunction (ED) and/or benign prostate hyperplasia (BPH) -associated symptoms. Besides its classical actions on PDE5 within the genitourinary tract, where the specific enzyme expression is maximal, it may exert different systemic effects. This is mainly due to the pleiotropic distribution of PDE5 enzyme throughout the human (and animal) body, where it can exert protective effects in different clinical conditions. Recently, it has been demonstrated that tadalafil may display novel actions on androgen receptor (AR) expression and activity and cytochrome P19a1 (Cyp19a1) and estrogen receptor β (ERβ) expression in different in vitro systems, such as adipose, bone and prostate cancer cells, where it can act as a selective modulator of steroid hormone production. This may determine novel potential mechanism(s) of control in pathophysiologic pathways. In this review, we summarize basic research and translational results applicable to the use of tadalafil in the treatment of obesity, bone loss and prostate cancer. |
| first_indexed | 2024-03-09T13:33:43Z |
| format | Article |
| id | doaj.art-1547803f115f474c989b5a1ea151b03a |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-09T13:33:43Z |
| publishDate | 2022-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-1547803f115f474c989b5a1ea151b03a2023-11-30T21:14:48ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672022-04-01238419110.3390/ijms23084191Tadalafil and Steroid Hormones Interactions in Adipose, Bone and Prostate Tissues: Focus on Translational PerspectivesEmanuela Alessandra Greco0Cristina Antinozzi1Luigi Di Luigi2Antonio Aversa3Paolo Sgrò4Department Unicusano, University “Niccolò Cusano”, 00166 Rome, ItalyDepartment of Movement, Human and Health Sciences, “Foro Italico” University, 00135 Rome, ItalyDepartment of Movement, Human and Health Sciences, “Foro Italico” University, 00135 Rome, ItalyDepartment of Experimental and Clinical Medicine, Magna Græcia University, 88100 Catanzaro, ItalyDepartment of Movement, Human and Health Sciences, “Foro Italico” University, 00135 Rome, ItalyTadalafil is a selective phosphodiesterase type-5 (PDE5) inhibitor that is approved for the treatment of men with erectile dysfunction (ED) and/or benign prostate hyperplasia (BPH) -associated symptoms. Besides its classical actions on PDE5 within the genitourinary tract, where the specific enzyme expression is maximal, it may exert different systemic effects. This is mainly due to the pleiotropic distribution of PDE5 enzyme throughout the human (and animal) body, where it can exert protective effects in different clinical conditions. Recently, it has been demonstrated that tadalafil may display novel actions on androgen receptor (AR) expression and activity and cytochrome P19a1 (Cyp19a1) and estrogen receptor β (ERβ) expression in different in vitro systems, such as adipose, bone and prostate cancer cells, where it can act as a selective modulator of steroid hormone production. This may determine novel potential mechanism(s) of control in pathophysiologic pathways. In this review, we summarize basic research and translational results applicable to the use of tadalafil in the treatment of obesity, bone loss and prostate cancer.https://www.mdpi.com/1422-0067/23/8/4191tadalafilprostate canceraromataseadipocytesboneandrogen receptors |
| spellingShingle | Emanuela Alessandra Greco Cristina Antinozzi Luigi Di Luigi Antonio Aversa Paolo Sgrò Tadalafil and Steroid Hormones Interactions in Adipose, Bone and Prostate Tissues: Focus on Translational Perspectives International Journal of Molecular Sciences tadalafil prostate cancer aromatase adipocytes bone androgen receptors |
| title | Tadalafil and Steroid Hormones Interactions in Adipose, Bone and Prostate Tissues: Focus on Translational Perspectives |
| title_full | Tadalafil and Steroid Hormones Interactions in Adipose, Bone and Prostate Tissues: Focus on Translational Perspectives |
| title_fullStr | Tadalafil and Steroid Hormones Interactions in Adipose, Bone and Prostate Tissues: Focus on Translational Perspectives |
| title_full_unstemmed | Tadalafil and Steroid Hormones Interactions in Adipose, Bone and Prostate Tissues: Focus on Translational Perspectives |
| title_short | Tadalafil and Steroid Hormones Interactions in Adipose, Bone and Prostate Tissues: Focus on Translational Perspectives |
| title_sort | tadalafil and steroid hormones interactions in adipose bone and prostate tissues focus on translational perspectives |
| topic | tadalafil prostate cancer aromatase adipocytes bone androgen receptors |
| url | https://www.mdpi.com/1422-0067/23/8/4191 |
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