The Limits between Schizophrenia and Bipolar Disorder: What Do Magnetic Resonance Findings Tell Us?
Schizophrenia and bipolar disorder, two of the most severe psychiatric illnesses, have historically been regarded as dichotomous entities but share many features of the premorbid course, clinical profile, genetic factors and treatment approaches. Studies focusing on neuroimaging findings have receiv...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-03-01
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| Series: | Behavioral Sciences |
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| Online Access: | https://www.mdpi.com/2076-328X/12/3/78 |
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| author | Mirona Letitia Dobri Alexandre Paim Diaz Sudhakar Selvaraj Joao Quevedo Consuelo Walss-Bass Jair C. Soares Marsal Sanches |
| author_facet | Mirona Letitia Dobri Alexandre Paim Diaz Sudhakar Selvaraj Joao Quevedo Consuelo Walss-Bass Jair C. Soares Marsal Sanches |
| author_sort | Mirona Letitia Dobri |
| collection | DOAJ |
| description | Schizophrenia and bipolar disorder, two of the most severe psychiatric illnesses, have historically been regarded as dichotomous entities but share many features of the premorbid course, clinical profile, genetic factors and treatment approaches. Studies focusing on neuroimaging findings have received considerable attention, as they plead for an improved understanding of the brain regions involved in the pathophysiology of schizophrenia and bipolar disorder. In this review, we summarize the main magnetic resonance imaging findings in both disorders, aiming at exploring the neuroanatomical and functional similarities and differences between the two. The findings show that gray and white matter structural changes and functional dysconnectivity predominate in the frontal and limbic areas and the frontotemporal circuitry of the brain areas involved in the integration of executive, cognitive and affective functions, commonly affected in both disorders. Available evidence points to a considerable overlap in the affected regions between the two conditions, therefore possibly placing them at opposite ends of a psychosis continuum. |
| first_indexed | 2024-03-09T20:06:27Z |
| format | Article |
| id | doaj.art-154b8028d5154c5a9edd3c6a3dccc9a4 |
| institution | Directory Open Access Journal |
| issn | 2076-328X |
| language | English |
| last_indexed | 2024-03-09T20:06:27Z |
| publishDate | 2022-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Behavioral Sciences |
| spelling | doaj.art-154b8028d5154c5a9edd3c6a3dccc9a42023-11-24T00:29:33ZengMDPI AGBehavioral Sciences2076-328X2022-03-011237810.3390/bs12030078The Limits between Schizophrenia and Bipolar Disorder: What Do Magnetic Resonance Findings Tell Us?Mirona Letitia Dobri0Alexandre Paim Diaz1Sudhakar Selvaraj2Joao Quevedo3Consuelo Walss-Bass4Jair C. Soares5Marsal Sanches6Center of Excellence on Mood Disorders, Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX 77054, USACenter of Excellence on Mood Disorders, Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX 77054, USACenter of Excellence on Mood Disorders, Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX 77054, USACenter of Excellence on Mood Disorders, Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX 77054, USACenter of Excellence on Mood Disorders, Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX 77054, USACenter of Excellence on Mood Disorders, Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX 77054, USACenter of Excellence on Mood Disorders, Faillace Department of Psychiatry and Behavioral Sciences, McGovern Medical School, The University of Texas Health Science Center at Houston (UTHealth), Houston, TX 77054, USASchizophrenia and bipolar disorder, two of the most severe psychiatric illnesses, have historically been regarded as dichotomous entities but share many features of the premorbid course, clinical profile, genetic factors and treatment approaches. Studies focusing on neuroimaging findings have received considerable attention, as they plead for an improved understanding of the brain regions involved in the pathophysiology of schizophrenia and bipolar disorder. In this review, we summarize the main magnetic resonance imaging findings in both disorders, aiming at exploring the neuroanatomical and functional similarities and differences between the two. The findings show that gray and white matter structural changes and functional dysconnectivity predominate in the frontal and limbic areas and the frontotemporal circuitry of the brain areas involved in the integration of executive, cognitive and affective functions, commonly affected in both disorders. Available evidence points to a considerable overlap in the affected regions between the two conditions, therefore possibly placing them at opposite ends of a psychosis continuum.https://www.mdpi.com/2076-328X/12/3/78bipolar disorderschizophreniamagnetic resonance imagingneuroimagingpathophysiology |
| spellingShingle | Mirona Letitia Dobri Alexandre Paim Diaz Sudhakar Selvaraj Joao Quevedo Consuelo Walss-Bass Jair C. Soares Marsal Sanches The Limits between Schizophrenia and Bipolar Disorder: What Do Magnetic Resonance Findings Tell Us? Behavioral Sciences bipolar disorder schizophrenia magnetic resonance imaging neuroimaging pathophysiology |
| title | The Limits between Schizophrenia and Bipolar Disorder: What Do Magnetic Resonance Findings Tell Us? |
| title_full | The Limits between Schizophrenia and Bipolar Disorder: What Do Magnetic Resonance Findings Tell Us? |
| title_fullStr | The Limits between Schizophrenia and Bipolar Disorder: What Do Magnetic Resonance Findings Tell Us? |
| title_full_unstemmed | The Limits between Schizophrenia and Bipolar Disorder: What Do Magnetic Resonance Findings Tell Us? |
| title_short | The Limits between Schizophrenia and Bipolar Disorder: What Do Magnetic Resonance Findings Tell Us? |
| title_sort | limits between schizophrenia and bipolar disorder what do magnetic resonance findings tell us |
| topic | bipolar disorder schizophrenia magnetic resonance imaging neuroimaging pathophysiology |
| url | https://www.mdpi.com/2076-328X/12/3/78 |
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