Therapeutic Potential of Astragaloside IV Against Adriamycin-Induced Renal Damage in Rats via Ferroptosis

Therapeutic Potential of Astragaloside IV Against Adriamycin-Induced Renal Damage in Rats via Ferroptosis

Adriamycin (ADR) has been utilized to treat cancer for several decades. However, ADR-induced renal injury is one of the most common side effects accompanying ADR therapy. In the present study, we revealed that astragaloside IV (ASIV) was beneficial for renal injury caused by Adriamycin. We demonstra...

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Bibliographic Details
Main Authors: Lu-Yun Qin, Peng Guan, Jian-Xin Wang, Yu Chen, Ya-Shuo Zhao, Sheng-Chang Yang, Ya-Jing Guo, Na Wang, En-Sheng Ji
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-03-01
Series:Frontiers in Pharmacology
Subjects:
kidney
astragaloside Ⅳ
Adriamycin
iron metabolism
ferroptosis
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.812594/full

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