Synthesis and characterization of related substances of Azilsartan Kamedoxomil
Azilsartan Kamedoxomil is an AT1-subtype angiotensin II receptor blocker (ARB). During the laboratory synthesis of Azilsartan Kamedoxomil, four related substances of Azilsartan Kamedoxomil were observed and identified. These were 2-Ethoxy-3-[[4-[2- [4-[(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl]-5-oxo-1...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Sciendo
2017-03-01
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| Series: | Current Issues in Pharmacy and Medical Sciences |
| Subjects: | |
| Online Access: | https://doi.org/10.1515/cipms-2017-0007 |
| _version_ | 1818728062198480896 |
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| author | Maddi N. V. D. Harikiran Garaga Srinivas Reddy Ambati V. Raghava Sanasi Paul Douglas Korupolu Raghubabu |
| author_facet | Maddi N. V. D. Harikiran Garaga Srinivas Reddy Ambati V. Raghava Sanasi Paul Douglas Korupolu Raghubabu |
| author_sort | Maddi N. V. D. Harikiran |
| collection | DOAJ |
| description | Azilsartan Kamedoxomil is an AT1-subtype angiotensin II receptor blocker (ARB). During the laboratory synthesis of Azilsartan Kamedoxomil, four related substances of Azilsartan Kamedoxomil were observed and identified. These were 2-Ethoxy-3-[[4-[2- [4-[(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl]-5-oxo-1,2,4-oxadiazol-3-yl]phenyl]phenyl] methyl] benzimidazole-4-carboxylic acid (azilsartan N-medoxomil, 9), (5-methyl-2-oxo- 1,3-dioxol-4-yl)methyl 2-ethoxy-3-[[4-[2-[4-[(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl]-5- oxo-1,2,4-oxadiazol-3-yl]phenyl]phenyl] methyl] benzimidazole-4-carboxylate (azilsartan dimedoxomil, 10), (5-methyl-2-oxo-1,3-dioxo-4-yl)methyl 1-[2’-(4,5-dihydro-5-oxo-4H- 1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]-2-methoxy-1H-benzimidazole-7-carboxylate (methoxy analogue of azilsartan medoxomil, 11), Methyl 1-((2’-amidobiphenyl-4-yl) methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (amide methyl ester, 12). The present work describes the origin, synthesis and characterization of these related substances. |
| first_indexed | 2024-12-17T22:24:01Z |
| format | Article |
| id | doaj.art-154c3d394f3b4ecea89030759d967a8a |
| institution | Directory Open Access Journal |
| issn | 2300-6676 |
| language | English |
| last_indexed | 2024-12-17T22:24:01Z |
| publishDate | 2017-03-01 |
| publisher | Sciendo |
| record_format | Article |
| series | Current Issues in Pharmacy and Medical Sciences |
| spelling | doaj.art-154c3d394f3b4ecea89030759d967a8a2022-12-21T21:30:24ZengSciendoCurrent Issues in Pharmacy and Medical Sciences2300-66762017-03-01301313510.1515/cipms-2017-0007cipms-2017-0007Synthesis and characterization of related substances of Azilsartan KamedoxomilMaddi N. V. D. Harikiran0Garaga Srinivas1Reddy Ambati V. Raghava2Sanasi Paul Douglas3Korupolu Raghubabu4Chemical Research and Development Department, Aurobindo Pharma Ltd, Survey No:71&72, Indrakaran Village, Sangareddy Mandal, Medak district, Hyderabad – 502329, Andhra Pradesh, IndiaChemical Research and Development Department, Aurobindo Pharma Ltd, Survey No:71&72, Indrakaran Village, Sangareddy Mandal, Medak district, Hyderabad – 502329, Andhra Pradesh, IndiaChemical Research and Development Department, Aurobindo Pharma Ltd, Survey No:71&72, Indrakaran Village, Sangareddy Mandal, Medak district, Hyderabad – 502329, Andhra Pradesh, IndiaDepartment of Engineering Chemistry, A. U. College of Engineering (A), Andhra University, Visakhapatnam – 530 003, Andhra Pradesh, IndiaDepartment of Engineering Chemistry, A. U. College of Engineering (A), Andhra University, Visakhapatnam – 530 003, Andhra Pradesh, IndiaAzilsartan Kamedoxomil is an AT1-subtype angiotensin II receptor blocker (ARB). During the laboratory synthesis of Azilsartan Kamedoxomil, four related substances of Azilsartan Kamedoxomil were observed and identified. These were 2-Ethoxy-3-[[4-[2- [4-[(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl]-5-oxo-1,2,4-oxadiazol-3-yl]phenyl]phenyl] methyl] benzimidazole-4-carboxylic acid (azilsartan N-medoxomil, 9), (5-methyl-2-oxo- 1,3-dioxol-4-yl)methyl 2-ethoxy-3-[[4-[2-[4-[(5-methyl-2-oxo-1,3-dioxol-4-yl)methyl]-5- oxo-1,2,4-oxadiazol-3-yl]phenyl]phenyl] methyl] benzimidazole-4-carboxylate (azilsartan dimedoxomil, 10), (5-methyl-2-oxo-1,3-dioxo-4-yl)methyl 1-[2’-(4,5-dihydro-5-oxo-4H- 1,2,4-oxadiazol-3-yl)biphenyl-4-yl]methyl]-2-methoxy-1H-benzimidazole-7-carboxylate (methoxy analogue of azilsartan medoxomil, 11), Methyl 1-((2’-amidobiphenyl-4-yl) methyl)-2-ethoxy-1H-benzo[d]imidazole-7-carboxylate (amide methyl ester, 12). The present work describes the origin, synthesis and characterization of these related substances.https://doi.org/10.1515/cipms-2017-0007azilsartan kamedoxomilrelated substancessynthesischaracterization |
| spellingShingle | Maddi N. V. D. Harikiran Garaga Srinivas Reddy Ambati V. Raghava Sanasi Paul Douglas Korupolu Raghubabu Synthesis and characterization of related substances of Azilsartan Kamedoxomil Current Issues in Pharmacy and Medical Sciences azilsartan kamedoxomil related substances synthesis characterization |
| title | Synthesis and characterization of related substances of Azilsartan Kamedoxomil |
| title_full | Synthesis and characterization of related substances of Azilsartan Kamedoxomil |
| title_fullStr | Synthesis and characterization of related substances of Azilsartan Kamedoxomil |
| title_full_unstemmed | Synthesis and characterization of related substances of Azilsartan Kamedoxomil |
| title_short | Synthesis and characterization of related substances of Azilsartan Kamedoxomil |
| title_sort | synthesis and characterization of related substances of azilsartan kamedoxomil |
| topic | azilsartan kamedoxomil related substances synthesis characterization |
| url | https://doi.org/10.1515/cipms-2017-0007 |
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