Spermatogonial Stem Cell Self - renewal and Differentiation
Mammalian spermatogenesis is a complicated and precisely controlled process that requires spermatogonial stem cells (SSCs). SSCs maintain the stem cell pool, balance self-renewal–commitment with differentiation, and produce millions of sperm daily. Self-renewal and differentiation are controlled by...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Health/LWW
2017-01-01
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| Series: | Reproductive and Developmental Medicine |
| Subjects: | |
| Online Access: | http://www.repdevmed.org/article.asp?issn=2096-2924;year=2017;volume=1;issue=3;spage=171;epage=178;aulast=Cao |
| _version_ | 1811317793511964672 |
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| author | Li-Huan Cao Qiao-Li Zhang Xin-Hua Lin |
| author_facet | Li-Huan Cao Qiao-Li Zhang Xin-Hua Lin |
| author_sort | Li-Huan Cao |
| collection | DOAJ |
| description | Mammalian spermatogenesis is a complicated and precisely controlled process that requires spermatogonial stem cells (SSCs). SSCs maintain the stem cell pool, balance self-renewal–commitment with differentiation, and produce millions of sperm daily. Self-renewal and differentiation are controlled by intrinsic factors within SSCs and extrinsic factors from the “niche.” In this review, we discuss the biology of SSCs and the factors regulating their self-renewal and differentiation. |
| first_indexed | 2024-04-13T12:14:34Z |
| format | Article |
| id | doaj.art-154d19d19bde424aafa8bbaa5a529577 |
| institution | Directory Open Access Journal |
| issn | 2096-2924 |
| language | English |
| last_indexed | 2024-04-13T12:14:34Z |
| publishDate | 2017-01-01 |
| publisher | Wolters Kluwer Health/LWW |
| record_format | Article |
| series | Reproductive and Developmental Medicine |
| spelling | doaj.art-154d19d19bde424aafa8bbaa5a5295772022-12-22T02:47:24ZengWolters Kluwer Health/LWWReproductive and Developmental Medicine2096-29242017-01-011317117810.4103/2096-2924.224213Spermatogonial Stem Cell Self - renewal and DifferentiationLi-Huan CaoQiao-Li ZhangXin-Hua LinMammalian spermatogenesis is a complicated and precisely controlled process that requires spermatogonial stem cells (SSCs). SSCs maintain the stem cell pool, balance self-renewal–commitment with differentiation, and produce millions of sperm daily. Self-renewal and differentiation are controlled by intrinsic factors within SSCs and extrinsic factors from the “niche.” In this review, we discuss the biology of SSCs and the factors regulating their self-renewal and differentiation.http://www.repdevmed.org/article.asp?issn=2096-2924;year=2017;volume=1;issue=3;spage=171;epage=178;aulast=CaoDifferentiation; Self-renewal; Spermatogonial Stem Cells |
| spellingShingle | Li-Huan Cao Qiao-Li Zhang Xin-Hua Lin Spermatogonial Stem Cell Self - renewal and Differentiation Reproductive and Developmental Medicine Differentiation; Self-renewal; Spermatogonial Stem Cells |
| title | Spermatogonial Stem Cell Self - renewal and Differentiation |
| title_full | Spermatogonial Stem Cell Self - renewal and Differentiation |
| title_fullStr | Spermatogonial Stem Cell Self - renewal and Differentiation |
| title_full_unstemmed | Spermatogonial Stem Cell Self - renewal and Differentiation |
| title_short | Spermatogonial Stem Cell Self - renewal and Differentiation |
| title_sort | spermatogonial stem cell self renewal and differentiation |
| topic | Differentiation; Self-renewal; Spermatogonial Stem Cells |
| url | http://www.repdevmed.org/article.asp?issn=2096-2924;year=2017;volume=1;issue=3;spage=171;epage=178;aulast=Cao |
| work_keys_str_mv | AT lihuancao spermatogonialstemcellselfrenewalanddifferentiation AT qiaolizhang spermatogonialstemcellselfrenewalanddifferentiation AT xinhualin spermatogonialstemcellselfrenewalanddifferentiation |