Comparative epidemiological study of breast cancer in humans and canine mammary tumors: insights from Portugal
Dogs spontaneously develop mammary gland tumors (MGT) and exhibit striking similarities in clinical and epidemiological characteristics to human breast cancer (HBC). Descriptive and comparative analysis of HBC and canine MGT with a focus on evaluating similarities and geographical distribution were...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-11-01
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| Series: | Frontiers in Veterinary Science |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fvets.2023.1271097/full |
| _version_ | 1797447695209594880 |
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| author | Paulo Tiago Carvalho João Niza-Ribeiro João Niza-Ribeiro João Niza-Ribeiro Irina Amorim Felisbina Queiroga Felisbina Queiroga Felisbina Queiroga Milton Severo Milton Severo Ana Isabel Ribeiro Ana Isabel Ribeiro Ana Isabel Ribeiro Katia Pinello Katia Pinello Katia Pinello |
| author_facet | Paulo Tiago Carvalho João Niza-Ribeiro João Niza-Ribeiro João Niza-Ribeiro Irina Amorim Felisbina Queiroga Felisbina Queiroga Felisbina Queiroga Milton Severo Milton Severo Ana Isabel Ribeiro Ana Isabel Ribeiro Ana Isabel Ribeiro Katia Pinello Katia Pinello Katia Pinello |
| author_sort | Paulo Tiago Carvalho |
| collection | DOAJ |
| description | Dogs spontaneously develop mammary gland tumors (MGT) and exhibit striking similarities in clinical and epidemiological characteristics to human breast cancer (HBC). Descriptive and comparative analysis of HBC and canine MGT with a focus on evaluating similarities and geographical distribution were the aims of this study. HBC cases were obtained from North Regional Oncological Registry (RORENO) (2010–2015) and canine MGT cases from Vet-OncoNet (2019–2022). Analyses were performed based on published and well accepted classification systems (ICD-O-3.2 for humans and Vet-ICD-O-canine-1). Age-standardized incidence risks (ASIR) of Porto district municipalities were calculated using 2021 Portuguese census (INE) and data from the Portuguese animal registration system (SIAC). Among 7,674 HBC cases and 1,140 MGT cases, a similar age and sex distribution pattern was observed. Approximately 69.2% of HBC cases were between 40 and 69 years old, while 66.9% of MGT cases were diagnosed between 7 and 12 years old (mean age of 9.6 years, SD = 2.6). In women, Invasive breast carcinoma (8500/3) was the most common histological type (n = 5,679, 74%) while in dogs it was the Complex Carcinoma (8983.1/3) (n = 205, 39%). Cocker and Yorkshire Terriers exhibited the highest relative risks (3.2 and 1.6, p < 0.05, respectively) when compared to cross breed dogs. The municipalities' ASIR of the two species exhibited a high correlation (R = 0.85, p < 0.01) and the spatial cluster analysis revealed similar geographic hotspots. Also, higher ASIR values both in women and dogs were more frequently found in urbanized areas compared to rural areas. This research sheds light on the shared features and geographical correlation between HBC and canine MGT, highlighting the potential of cross-species environmental oncology studies. |
| first_indexed | 2024-03-09T13:59:38Z |
| format | Article |
| id | doaj.art-154da51069274eaf84692d3dbea4b927 |
| institution | Directory Open Access Journal |
| issn | 2297-1769 |
| language | English |
| last_indexed | 2024-03-09T13:59:38Z |
| publishDate | 2023-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Veterinary Science |
| spelling | doaj.art-154da51069274eaf84692d3dbea4b9272023-11-30T08:35:47ZengFrontiers Media S.A.Frontiers in Veterinary Science2297-17692023-11-011010.3389/fvets.2023.12710971271097Comparative epidemiological study of breast cancer in humans and canine mammary tumors: insights from PortugalPaulo Tiago Carvalho0João Niza-Ribeiro1João Niza-Ribeiro2João Niza-Ribeiro3Irina Amorim4Felisbina Queiroga5Felisbina Queiroga6Felisbina Queiroga7Milton Severo8Milton Severo9Ana Isabel Ribeiro10Ana Isabel Ribeiro11Ana Isabel Ribeiro12Katia Pinello13Katia Pinello14Katia Pinello15Vet-OncoNet, Population Studies Department, School of Medicine and Biomedical Sciences, ICBAS, University of Porto, Porto, PortugalVet-OncoNet, Population Studies Department, School of Medicine and Biomedical Sciences, ICBAS, University of Porto, Porto, PortugalEpidemiology Unit (EPIUnit), Institute of Public Health of the University of Porto (ISPUP), Porto, PortugalLaboratory for Integrative and Translational Research in Population Health (ITR), Porto, PortugalDepartment of Pathology and Molecular Immunology, School of Medicine and Biomedical Sciences ICBAS, University of Porto, Porto, PortugalDepartment of Veterinary Sciences, University Trás-os-Montes and Alto Douro (UTAD), Vila Real, PortugalCentre for Animal and Veterinary Science (CECAV), University of Trás-os-Montes and Alto Douro, Vila Real, PortugalCenter for Animal Science Studies, Institute of Sciences, Technologies and Agroenvironment (CECA-ICETA), University of Porto, Porto, PortugalEpidemiology Unit (EPIUnit), Institute of Public Health of the University of Porto (ISPUP), Porto, PortugalLaboratory for Integrative and Translational Research in Population Health (ITR), Porto, PortugalEpidemiology Unit (EPIUnit), Institute of Public Health of the University of Porto (ISPUP), Porto, PortugalLaboratory for Integrative and Translational Research in Population Health (ITR), Porto, PortugalDepartment of Public Health and Forensic Sciences and Medical Education, Faculty of Medicine, University of Porto, Porto, PortugalVet-OncoNet, Population Studies Department, School of Medicine and Biomedical Sciences, ICBAS, University of Porto, Porto, PortugalEpidemiology Unit (EPIUnit), Institute of Public Health of the University of Porto (ISPUP), Porto, PortugalLaboratory for Integrative and Translational Research in Population Health (ITR), Porto, PortugalDogs spontaneously develop mammary gland tumors (MGT) and exhibit striking similarities in clinical and epidemiological characteristics to human breast cancer (HBC). Descriptive and comparative analysis of HBC and canine MGT with a focus on evaluating similarities and geographical distribution were the aims of this study. HBC cases were obtained from North Regional Oncological Registry (RORENO) (2010–2015) and canine MGT cases from Vet-OncoNet (2019–2022). Analyses were performed based on published and well accepted classification systems (ICD-O-3.2 for humans and Vet-ICD-O-canine-1). Age-standardized incidence risks (ASIR) of Porto district municipalities were calculated using 2021 Portuguese census (INE) and data from the Portuguese animal registration system (SIAC). Among 7,674 HBC cases and 1,140 MGT cases, a similar age and sex distribution pattern was observed. Approximately 69.2% of HBC cases were between 40 and 69 years old, while 66.9% of MGT cases were diagnosed between 7 and 12 years old (mean age of 9.6 years, SD = 2.6). In women, Invasive breast carcinoma (8500/3) was the most common histological type (n = 5,679, 74%) while in dogs it was the Complex Carcinoma (8983.1/3) (n = 205, 39%). Cocker and Yorkshire Terriers exhibited the highest relative risks (3.2 and 1.6, p < 0.05, respectively) when compared to cross breed dogs. The municipalities' ASIR of the two species exhibited a high correlation (R = 0.85, p < 0.01) and the spatial cluster analysis revealed similar geographic hotspots. Also, higher ASIR values both in women and dogs were more frequently found in urbanized areas compared to rural areas. This research sheds light on the shared features and geographical correlation between HBC and canine MGT, highlighting the potential of cross-species environmental oncology studies.https://www.frontiersin.org/articles/10.3389/fvets.2023.1271097/fullbreast cancercaninecluster analysiscomparative oncologyenvironmentalLISA cluster analysis |
| spellingShingle | Paulo Tiago Carvalho João Niza-Ribeiro João Niza-Ribeiro João Niza-Ribeiro Irina Amorim Felisbina Queiroga Felisbina Queiroga Felisbina Queiroga Milton Severo Milton Severo Ana Isabel Ribeiro Ana Isabel Ribeiro Ana Isabel Ribeiro Katia Pinello Katia Pinello Katia Pinello Comparative epidemiological study of breast cancer in humans and canine mammary tumors: insights from Portugal Frontiers in Veterinary Science breast cancer canine cluster analysis comparative oncology environmental LISA cluster analysis |
| title | Comparative epidemiological study of breast cancer in humans and canine mammary tumors: insights from Portugal |
| title_full | Comparative epidemiological study of breast cancer in humans and canine mammary tumors: insights from Portugal |
| title_fullStr | Comparative epidemiological study of breast cancer in humans and canine mammary tumors: insights from Portugal |
| title_full_unstemmed | Comparative epidemiological study of breast cancer in humans and canine mammary tumors: insights from Portugal |
| title_short | Comparative epidemiological study of breast cancer in humans and canine mammary tumors: insights from Portugal |
| title_sort | comparative epidemiological study of breast cancer in humans and canine mammary tumors insights from portugal |
| topic | breast cancer canine cluster analysis comparative oncology environmental LISA cluster analysis |
| url | https://www.frontiersin.org/articles/10.3389/fvets.2023.1271097/full |
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