Naoxintong capsule delay the progression of diabetic kidney disease: A real-world cohort study
IntroductionDiabetic kidney disease (DKD) is a severe and growing health problem, associated with a worse prognosis and higher overall mortality rates than non-diabetic renal disease. Chinese herbs possess promising clinical benefits in alleviating the progression of DKD due to their multi-target ef...
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| Format: | Article |
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Frontiers Media S.A.
2022-11-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2022.1037564/full |
| _version_ | 1811231146939252736 |
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| author | Yuqing Zhang Yuehong Zhang Cunqing Yang Yingying Duan Linlin Jiang De Jin Fengmei Lian Xiaolin Tong |
| author_facet | Yuqing Zhang Yuehong Zhang Cunqing Yang Yingying Duan Linlin Jiang De Jin Fengmei Lian Xiaolin Tong |
| author_sort | Yuqing Zhang |
| collection | DOAJ |
| description | IntroductionDiabetic kidney disease (DKD) is a severe and growing health problem, associated with a worse prognosis and higher overall mortality rates than non-diabetic renal disease. Chinese herbs possess promising clinical benefits in alleviating the progression of DKD due to their multi-target effect. This real-world retrospective cohort trial aimed to investigate the efficacy and safety of Naoxintong (NXT) capsules in the treatment of DKD. Our study is the first real-world study (RWS) of NXT in the treatment of DKD based on a large database, providing a basis for clinical application and promotion.MethodsThe data was collected from Tianjin Healthcare and Medical Big Data Platform. Patients with DKD were enrolled from January 1, 2011, to March 31, 2021. NXT administration was defined as the exposure. The primary outcome was the change in estimated glomerular filtration rate (eGFR). We employed the propensity score matching (PSM) method to deal with confounding factors.ResultsA total of 1,798 patients were enrolled after PSM, including 899 NXT users (exposed group) and 899 non-users (control group). The eGFR changes from baseline to the end of the study were significantly different in the exposed group compared to the control group (-1.46 ± 21.94 vs -5.82 ± 19.8 mL/(min·1.73m2), P< 0.01). Patients in the NXT group had a lower risk of composite renal outcome event (HR, 0.71; 95%CI, 0.55 to 0.92; P = 0.009) and deterioration of renal function (HR, 0.74; 95% CI, 0.56 to 0.99; P = 0.039).ConclusionNXT can significantly slow the decline of eGFR and reduce the risk of renal outcomes. However, large cohort studies and RCTs are needed to further confirm our results. |
| first_indexed | 2024-04-12T10:39:59Z |
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| id | doaj.art-154e72e8c45e42e08f3b48bf3b57fb33 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-12T10:39:59Z |
| publishDate | 2022-11-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-154e72e8c45e42e08f3b48bf3b57fb332022-12-22T03:36:37ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922022-11-011310.3389/fendo.2022.10375641037564Naoxintong capsule delay the progression of diabetic kidney disease: A real-world cohort studyYuqing Zhang0Yuehong Zhang1Cunqing Yang2Yingying Duan3Linlin Jiang4De Jin5Fengmei Lian6Xiaolin Tong7Endocrinology Department, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaEndocrinology Department, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaEndocrinology Department, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaEndocrinology Department, Guang’anmen Hospital, Beijing University of Chinese Medicine, Beijing, ChinaEndocrinology Department, Guang’anmen Hospital, Beijing University of Chinese Medicine, Beijing, ChinaDepartment of Nephrology, Hangzhou Hospital of Traditional Chinese Medicine, Hangzhou, Zhejiang, ChinaEndocrinology Department, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaInstitute of Metabolic Diseases, Guang’anmen Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaIntroductionDiabetic kidney disease (DKD) is a severe and growing health problem, associated with a worse prognosis and higher overall mortality rates than non-diabetic renal disease. Chinese herbs possess promising clinical benefits in alleviating the progression of DKD due to their multi-target effect. This real-world retrospective cohort trial aimed to investigate the efficacy and safety of Naoxintong (NXT) capsules in the treatment of DKD. Our study is the first real-world study (RWS) of NXT in the treatment of DKD based on a large database, providing a basis for clinical application and promotion.MethodsThe data was collected from Tianjin Healthcare and Medical Big Data Platform. Patients with DKD were enrolled from January 1, 2011, to March 31, 2021. NXT administration was defined as the exposure. The primary outcome was the change in estimated glomerular filtration rate (eGFR). We employed the propensity score matching (PSM) method to deal with confounding factors.ResultsA total of 1,798 patients were enrolled after PSM, including 899 NXT users (exposed group) and 899 non-users (control group). The eGFR changes from baseline to the end of the study were significantly different in the exposed group compared to the control group (-1.46 ± 21.94 vs -5.82 ± 19.8 mL/(min·1.73m2), P< 0.01). Patients in the NXT group had a lower risk of composite renal outcome event (HR, 0.71; 95%CI, 0.55 to 0.92; P = 0.009) and deterioration of renal function (HR, 0.74; 95% CI, 0.56 to 0.99; P = 0.039).ConclusionNXT can significantly slow the decline of eGFR and reduce the risk of renal outcomes. However, large cohort studies and RCTs are needed to further confirm our results.https://www.frontiersin.org/articles/10.3389/fendo.2022.1037564/fullNaoxintong capsulediabetic kidney diseaseretrospective cohort studypropensity score matchingreal-world study |
| spellingShingle | Yuqing Zhang Yuehong Zhang Cunqing Yang Yingying Duan Linlin Jiang De Jin Fengmei Lian Xiaolin Tong Naoxintong capsule delay the progression of diabetic kidney disease: A real-world cohort study Frontiers in Endocrinology Naoxintong capsule diabetic kidney disease retrospective cohort study propensity score matching real-world study |
| title | Naoxintong capsule delay the progression of diabetic kidney disease: A real-world cohort study |
| title_full | Naoxintong capsule delay the progression of diabetic kidney disease: A real-world cohort study |
| title_fullStr | Naoxintong capsule delay the progression of diabetic kidney disease: A real-world cohort study |
| title_full_unstemmed | Naoxintong capsule delay the progression of diabetic kidney disease: A real-world cohort study |
| title_short | Naoxintong capsule delay the progression of diabetic kidney disease: A real-world cohort study |
| title_sort | naoxintong capsule delay the progression of diabetic kidney disease a real world cohort study |
| topic | Naoxintong capsule diabetic kidney disease retrospective cohort study propensity score matching real-world study |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2022.1037564/full |
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