Dissociation Between Insulin Resistance and Abnormalities in Lipoprotein Particle Concentrations and Sizes in Normal-Weight Chinese Adults
Insulin resistance in obesity coincides with abnormalities in lipid profile and lipoprotein subclass distribution and size even before abnormalities in glucose homeostasis manifest. We aimed to assess this relationship in the absence of obesity. Insulin sensitivity (3-h intravenous glucose tolerance...
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Frontiers Media S.A.
2021-02-01
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| Series: | Frontiers in Nutrition |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnut.2021.651199/full |
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| author | Kaare Tranæs Cherlyn Ding Yu Chung Chooi Zhiling Chan John Choo Melvin K.-S. Leow Melvin K.-S. Leow Melvin K.-S. Leow Melvin K.-S. Leow Faidon Magkos Faidon Magkos |
| author_facet | Kaare Tranæs Cherlyn Ding Yu Chung Chooi Zhiling Chan John Choo Melvin K.-S. Leow Melvin K.-S. Leow Melvin K.-S. Leow Melvin K.-S. Leow Faidon Magkos Faidon Magkos |
| author_sort | Kaare Tranæs |
| collection | DOAJ |
| description | Insulin resistance in obesity coincides with abnormalities in lipid profile and lipoprotein subclass distribution and size even before abnormalities in glucose homeostasis manifest. We aimed to assess this relationship in the absence of obesity. Insulin sensitivity (3-h intravenous glucose tolerance test and minimal modeling) and lipoprotein particle concentrations and sizes (proton nuclear magnetic resonance spectroscopy) were evaluated in 15 insulin-resistant and 15 insulin-sensitive lean Asians of Chinese descent with normal glucose tolerance, matched on age, sex, and body mass index. Despite a ~50% lower insulin sensitivity index (Si) in insulin-resistant than in insulin-sensitive subjects, which was accompanied by significantly greater acute insulin response to glucose (AIRg) and fasting insulin concentration but not different fasting glucose concentration, there were no significant differences between groups in the blood lipid profile (p ≥ 0.44) or the lipoprotein subclass concentrations (p ≥ 0.30) and particle sizes (p ≥ 0.43). We conclude that, contrary to observations in subjects with obesity, insulin resistance is not accompanied by unfavorable changes in the plasma lipid profile and lipoprotein particle concentrations and sizes in lean Asians with normal glucose tolerance. Therefore, insulin resistance at the level of glucose metabolism is mechanistically or temporally dissociated from lipid and lipoprotein metabolism.Trial Registration:clinicaltrials.gov, NCT03264001. |
| first_indexed | 2024-12-19T06:36:47Z |
| format | Article |
| id | doaj.art-154ee6064cf0404bb8e8b09ee5e41f4d |
| institution | Directory Open Access Journal |
| issn | 2296-861X |
| language | English |
| last_indexed | 2024-12-19T06:36:47Z |
| publishDate | 2021-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Nutrition |
| spelling | doaj.art-154ee6064cf0404bb8e8b09ee5e41f4d2022-12-21T20:32:13ZengFrontiers Media S.A.Frontiers in Nutrition2296-861X2021-02-01810.3389/fnut.2021.651199651199Dissociation Between Insulin Resistance and Abnormalities in Lipoprotein Particle Concentrations and Sizes in Normal-Weight Chinese AdultsKaare Tranæs0Cherlyn Ding1Yu Chung Chooi2Zhiling Chan3John Choo4Melvin K.-S. Leow5Melvin K.-S. Leow6Melvin K.-S. Leow7Melvin K.-S. Leow8Faidon Magkos9Faidon Magkos10Section for Obesity Research, Department of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg, DenmarkSingapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR) and National University Health System, Singapore, SingaporeSingapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR) and National University Health System, Singapore, SingaporeSingapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR) and National University Health System, Singapore, SingaporeSingapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR) and National University Health System, Singapore, SingaporeSingapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR) and National University Health System, Singapore, SingaporeDepartment of Endocrinology, Tan Tock Seng Hospital, Singapore, SingaporeCardiovascular and Metabolic Disorders Program, Duke-NUS Medical School, Singapore, SingaporeLee Kong Chian School of Medicine, Nanyang Technological University, Singapore, SingaporeSection for Obesity Research, Department of Nutrition, Exercise and Sports, University of Copenhagen, Frederiksberg, DenmarkSingapore Institute for Clinical Sciences (SICS), Agency for Science, Technology and Research (A*STAR) and National University Health System, Singapore, SingaporeInsulin resistance in obesity coincides with abnormalities in lipid profile and lipoprotein subclass distribution and size even before abnormalities in glucose homeostasis manifest. We aimed to assess this relationship in the absence of obesity. Insulin sensitivity (3-h intravenous glucose tolerance test and minimal modeling) and lipoprotein particle concentrations and sizes (proton nuclear magnetic resonance spectroscopy) were evaluated in 15 insulin-resistant and 15 insulin-sensitive lean Asians of Chinese descent with normal glucose tolerance, matched on age, sex, and body mass index. Despite a ~50% lower insulin sensitivity index (Si) in insulin-resistant than in insulin-sensitive subjects, which was accompanied by significantly greater acute insulin response to glucose (AIRg) and fasting insulin concentration but not different fasting glucose concentration, there were no significant differences between groups in the blood lipid profile (p ≥ 0.44) or the lipoprotein subclass concentrations (p ≥ 0.30) and particle sizes (p ≥ 0.43). We conclude that, contrary to observations in subjects with obesity, insulin resistance is not accompanied by unfavorable changes in the plasma lipid profile and lipoprotein particle concentrations and sizes in lean Asians with normal glucose tolerance. Therefore, insulin resistance at the level of glucose metabolism is mechanistically or temporally dissociated from lipid and lipoprotein metabolism.Trial Registration:clinicaltrials.gov, NCT03264001.https://www.frontiersin.org/articles/10.3389/fnut.2021.651199/fullinsulin resistancelipoprotein particle sizeobesity phenotypesmetabolically-unhealthy leannuclear magnetic resonance |
| spellingShingle | Kaare Tranæs Cherlyn Ding Yu Chung Chooi Zhiling Chan John Choo Melvin K.-S. Leow Melvin K.-S. Leow Melvin K.-S. Leow Melvin K.-S. Leow Faidon Magkos Faidon Magkos Dissociation Between Insulin Resistance and Abnormalities in Lipoprotein Particle Concentrations and Sizes in Normal-Weight Chinese Adults Frontiers in Nutrition insulin resistance lipoprotein particle size obesity phenotypes metabolically-unhealthy lean nuclear magnetic resonance |
| title | Dissociation Between Insulin Resistance and Abnormalities in Lipoprotein Particle Concentrations and Sizes in Normal-Weight Chinese Adults |
| title_full | Dissociation Between Insulin Resistance and Abnormalities in Lipoprotein Particle Concentrations and Sizes in Normal-Weight Chinese Adults |
| title_fullStr | Dissociation Between Insulin Resistance and Abnormalities in Lipoprotein Particle Concentrations and Sizes in Normal-Weight Chinese Adults |
| title_full_unstemmed | Dissociation Between Insulin Resistance and Abnormalities in Lipoprotein Particle Concentrations and Sizes in Normal-Weight Chinese Adults |
| title_short | Dissociation Between Insulin Resistance and Abnormalities in Lipoprotein Particle Concentrations and Sizes in Normal-Weight Chinese Adults |
| title_sort | dissociation between insulin resistance and abnormalities in lipoprotein particle concentrations and sizes in normal weight chinese adults |
| topic | insulin resistance lipoprotein particle size obesity phenotypes metabolically-unhealthy lean nuclear magnetic resonance |
| url | https://www.frontiersin.org/articles/10.3389/fnut.2021.651199/full |
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