Aggressive Fibromatosis of the Left Mesocolon Mimicking a Gastrointestinal Stromal Tumor: A Case Report
Mesenteric fibromatosis (MF) is a proliferative fibroblastic lesion of the intestinal mesentery. It constitutes 8% of all desmoid tumors, representing 0.03% of all neoplasms. It is benign histologically, although it could infiltrate locally and recur following excision; however, it is free from the...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Karger Publishers
2023-10-01
|
| Series: | Case Reports in Oncology |
| Subjects: | |
| Online Access: | https://beta.karger.com/Article/FullText/534038 |
| _version_ | 1797626805132197888 |
|---|---|
| author | Mohammad Abu-Jeyyab Hanna Al-Asbahi Mohammad Al-Jafari Bushra Khalaf Al-Tarawneh Abdulqadir J. Nashwan |
| author_facet | Mohammad Abu-Jeyyab Hanna Al-Asbahi Mohammad Al-Jafari Bushra Khalaf Al-Tarawneh Abdulqadir J. Nashwan |
| author_sort | Mohammad Abu-Jeyyab |
| collection | DOAJ |
| description | Mesenteric fibromatosis (MF) is a proliferative fibroblastic lesion of the intestinal mesentery. It constitutes 8% of all desmoid tumors, representing 0.03% of all neoplasms. It is benign histologically, although it could infiltrate locally and recur following excision; however, it is free from the potential to metastasize. It is spontaneous or associated with familial adenomatous polyposis (FAP]) mutation as a part of Gardner’s syndrome. This case report discusses the radiological, intraoperative, and histopathological findings from a 45-year-old male patient who presented with abdominal pain and a palpable mass in the left hemiabdomen. The pain was dull and aching, extending to the back and unrelated to any other gastrointestinal symptoms. There was no history of severe weight reduction. Furthermore, he is not a smoker. There were no comorbidities, severe medical diseases, or prior surgical procedures. Computerized tomography revealed a well-defined, lobulated, heterogeneously enhancing altered signal intensity mass at the mesocolon. Ultrasonography of the abdomen showed an intra-abdominal mass. Macroscopic mass characteristics include a well-defined mass measuring 22 × 14 × 11 cm connected to a small intestine segment measuring 21 × 2 × 2 cm. Histopathological and immunohistochemical examinations of the resected tumor, including positive nuclear immunostaining for beta-catenin, confirmed a postoperative diagnosis of desmoid-type fibromatosis. Based on its clinical presentation and computed tomography results, this case demonstrated how desmoid-type fibromatosis of the colon might mimic gastrointestinal stromal tumors (GISTs). Due to the varied therapies and follow-up methods used for these lesions, the differential diagnosis between desmoid-type fibromatosis and GIST is clinically significant. |
| first_indexed | 2024-03-11T10:15:25Z |
| format | Article |
| id | doaj.art-1550a8c403db4554ace908d940af8db0 |
| institution | Directory Open Access Journal |
| issn | 1662-6575 |
| language | English |
| last_indexed | 2024-03-11T10:15:25Z |
| publishDate | 2023-10-01 |
| publisher | Karger Publishers |
| record_format | Article |
| series | Case Reports in Oncology |
| spelling | doaj.art-1550a8c403db4554ace908d940af8db02023-11-16T07:58:20ZengKarger PublishersCase Reports in Oncology1662-65752023-10-011611148115510.1159/000534038534038Aggressive Fibromatosis of the Left Mesocolon Mimicking a Gastrointestinal Stromal Tumor: A Case ReportMohammad Abu-Jeyyab0Hanna Al-Asbahi1Mohammad Al-Jafari2Bushra Khalaf Al-Tarawneh3Abdulqadir J. Nashwan4https://orcid.org/0000-0003-4845-4119School of Medicine, Mutah University, Al-Karak, JordanGeneral Surgery Department, Al-Basheer Hospital, Amman, JordanSchool of Medicine, Mutah University, Al-Karak, JordanPathology and Microbiology Department, School of Medicine, Mutah University, Al-Karak, JordanHamad Medical Corporation, Doha, QatarMesenteric fibromatosis (MF) is a proliferative fibroblastic lesion of the intestinal mesentery. It constitutes 8% of all desmoid tumors, representing 0.03% of all neoplasms. It is benign histologically, although it could infiltrate locally and recur following excision; however, it is free from the potential to metastasize. It is spontaneous or associated with familial adenomatous polyposis (FAP]) mutation as a part of Gardner’s syndrome. This case report discusses the radiological, intraoperative, and histopathological findings from a 45-year-old male patient who presented with abdominal pain and a palpable mass in the left hemiabdomen. The pain was dull and aching, extending to the back and unrelated to any other gastrointestinal symptoms. There was no history of severe weight reduction. Furthermore, he is not a smoker. There were no comorbidities, severe medical diseases, or prior surgical procedures. Computerized tomography revealed a well-defined, lobulated, heterogeneously enhancing altered signal intensity mass at the mesocolon. Ultrasonography of the abdomen showed an intra-abdominal mass. Macroscopic mass characteristics include a well-defined mass measuring 22 × 14 × 11 cm connected to a small intestine segment measuring 21 × 2 × 2 cm. Histopathological and immunohistochemical examinations of the resected tumor, including positive nuclear immunostaining for beta-catenin, confirmed a postoperative diagnosis of desmoid-type fibromatosis. Based on its clinical presentation and computed tomography results, this case demonstrated how desmoid-type fibromatosis of the colon might mimic gastrointestinal stromal tumors (GISTs). Due to the varied therapies and follow-up methods used for these lesions, the differential diagnosis between desmoid-type fibromatosis and GIST is clinically significant.https://beta.karger.com/Article/FullText/534038fibromatosisgastrointestinal stromal tumormesocolonpreoperative diagnosis |
| spellingShingle | Mohammad Abu-Jeyyab Hanna Al-Asbahi Mohammad Al-Jafari Bushra Khalaf Al-Tarawneh Abdulqadir J. Nashwan Aggressive Fibromatosis of the Left Mesocolon Mimicking a Gastrointestinal Stromal Tumor: A Case Report Case Reports in Oncology fibromatosis gastrointestinal stromal tumor mesocolon preoperative diagnosis |
| title | Aggressive Fibromatosis of the Left Mesocolon Mimicking a Gastrointestinal Stromal Tumor: A Case Report |
| title_full | Aggressive Fibromatosis of the Left Mesocolon Mimicking a Gastrointestinal Stromal Tumor: A Case Report |
| title_fullStr | Aggressive Fibromatosis of the Left Mesocolon Mimicking a Gastrointestinal Stromal Tumor: A Case Report |
| title_full_unstemmed | Aggressive Fibromatosis of the Left Mesocolon Mimicking a Gastrointestinal Stromal Tumor: A Case Report |
| title_short | Aggressive Fibromatosis of the Left Mesocolon Mimicking a Gastrointestinal Stromal Tumor: A Case Report |
| title_sort | aggressive fibromatosis of the left mesocolon mimicking a gastrointestinal stromal tumor a case report |
| topic | fibromatosis gastrointestinal stromal tumor mesocolon preoperative diagnosis |
| url | https://beta.karger.com/Article/FullText/534038 |
| work_keys_str_mv | AT mohammadabujeyyab aggressivefibromatosisoftheleftmesocolonmimickingagastrointestinalstromaltumoracasereport AT hannaalasbahi aggressivefibromatosisoftheleftmesocolonmimickingagastrointestinalstromaltumoracasereport AT mohammadaljafari aggressivefibromatosisoftheleftmesocolonmimickingagastrointestinalstromaltumoracasereport AT bushrakhalafaltarawneh aggressivefibromatosisoftheleftmesocolonmimickingagastrointestinalstromaltumoracasereport AT abdulqadirjnashwan aggressivefibromatosisoftheleftmesocolonmimickingagastrointestinalstromaltumoracasereport |