Effects of Rh-endostar in Combination with Radiotherapy on Rats with Lung Cancer
Background and objective Radiation sensitivity is closely related to tissue oxygen, and rh-endostatin can induce the high level of oxygen content in tumor by "normalizing" tumor angiogenesis which is associated with radiotherapy sensitivity. The aim of this study is to observe the effect o...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | zho |
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Chinese Anti-Cancer Association; Chinese Antituberculosis Association
2010-04-01
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| Series: | Chinese Journal of Lung Cancer |
| Subjects: | |
| Online Access: | http://www.lungca.org/index.php?journal=01&page=article&op=viewFile&path[]=10.3779%2Fj.issn.1009-3419.2010.04.22&path[]=1443 |
| _version_ | 1828542215391019008 |
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| author | Ximin XU Zhenyu ZHAO Changhu LI Wei GE Du HE Fang YANG |
| author_facet | Ximin XU Zhenyu ZHAO Changhu LI Wei GE Du HE Fang YANG |
| author_sort | Ximin XU |
| collection | DOAJ |
| description | Background and objective Radiation sensitivity is closely related to tissue oxygen, and rh-endostatin can induce the high level of oxygen content in tumor by "normalizing" tumor angiogenesis which is associated with radiotherapy sensitivity. The aim of this study is to observe the effect of combination of radiotherapy with rh-endostatin in the rats with lung cancer. Methods Immediate lewis cancerous ascetic injection method was used to make rats tumors bearing model, then the rats was divided into four groups randomly: group A was treated with saline; group B was treated with rh-endostatin; group C was treated with irradiation and group D was treated with rh-endostatin and irradiation. After all rats were treated, inhibition rates and the tumor growth curve were calculated. Immunohistochemisty was adopted to check the expressions of vascular endothelial growth factor (VEGF) and microvessel density (MVD). Results Compared with group A, the growth rates of the tumors in the other group were obviously slower, and the tumor weights were significantly different form group A (P<0.05). Compared with the other groups, the tumor weights of group D were obviously reduced (P<0.05). Compared with group A, VEGF and MVD of other three groups were reduced (P<0.05), and group D were significantly cut down. Conclusion Combination with radiotherapy and rh-endostatin could inhibit the lung cancer significantly in rats. The possible mechanisms are to decrease the expression of VEGF and inhibit the production of angiogenesis. |
| first_indexed | 2024-12-12T01:52:06Z |
| format | Article |
| id | doaj.art-15514b577ebc487ea51c24ef29627382 |
| institution | Directory Open Access Journal |
| issn | 1009-3419 1999-6187 |
| language | zho |
| last_indexed | 2024-12-12T01:52:06Z |
| publishDate | 2010-04-01 |
| publisher | Chinese Anti-Cancer Association; Chinese Antituberculosis Association |
| record_format | Article |
| series | Chinese Journal of Lung Cancer |
| spelling | doaj.art-15514b577ebc487ea51c24ef296273822022-12-22T00:42:27ZzhoChinese Anti-Cancer Association; Chinese Antituberculosis AssociationChinese Journal of Lung Cancer1009-34191999-61872010-04-01134386390Effects of Rh-endostar in Combination with Radiotherapy on Rats with Lung CancerXimin XUZhenyu ZHAOChanghu LIWei GEDu HEFang YANGBackground and objective Radiation sensitivity is closely related to tissue oxygen, and rh-endostatin can induce the high level of oxygen content in tumor by "normalizing" tumor angiogenesis which is associated with radiotherapy sensitivity. The aim of this study is to observe the effect of combination of radiotherapy with rh-endostatin in the rats with lung cancer. Methods Immediate lewis cancerous ascetic injection method was used to make rats tumors bearing model, then the rats was divided into four groups randomly: group A was treated with saline; group B was treated with rh-endostatin; group C was treated with irradiation and group D was treated with rh-endostatin and irradiation. After all rats were treated, inhibition rates and the tumor growth curve were calculated. Immunohistochemisty was adopted to check the expressions of vascular endothelial growth factor (VEGF) and microvessel density (MVD). Results Compared with group A, the growth rates of the tumors in the other group were obviously slower, and the tumor weights were significantly different form group A (P<0.05). Compared with the other groups, the tumor weights of group D were obviously reduced (P<0.05). Compared with group A, VEGF and MVD of other three groups were reduced (P<0.05), and group D were significantly cut down. Conclusion Combination with radiotherapy and rh-endostatin could inhibit the lung cancer significantly in rats. The possible mechanisms are to decrease the expression of VEGF and inhibit the production of angiogenesis.http://www.lungca.org/index.php?journal=01&page=article&op=viewFile&path[]=10.3779%2Fj.issn.1009-3419.2010.04.22&path[]=1443Lung neoplasmsRadiotherapyRh-endostatin |
| spellingShingle | Ximin XU Zhenyu ZHAO Changhu LI Wei GE Du HE Fang YANG Effects of Rh-endostar in Combination with Radiotherapy on Rats with Lung Cancer Chinese Journal of Lung Cancer Lung neoplasms Radiotherapy Rh-endostatin |
| title | Effects of Rh-endostar in Combination with Radiotherapy on Rats with Lung Cancer |
| title_full | Effects of Rh-endostar in Combination with Radiotherapy on Rats with Lung Cancer |
| title_fullStr | Effects of Rh-endostar in Combination with Radiotherapy on Rats with Lung Cancer |
| title_full_unstemmed | Effects of Rh-endostar in Combination with Radiotherapy on Rats with Lung Cancer |
| title_short | Effects of Rh-endostar in Combination with Radiotherapy on Rats with Lung Cancer |
| title_sort | effects of rh endostar in combination with radiotherapy on rats with lung cancer |
| topic | Lung neoplasms Radiotherapy Rh-endostatin |
| url | http://www.lungca.org/index.php?journal=01&page=article&op=viewFile&path[]=10.3779%2Fj.issn.1009-3419.2010.04.22&path[]=1443 |
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