Forward and reverse typing discrepancy and crossmatch incompatibility of ABO blood groups: cause analysis and treatment

ABSTRACTObjective Analyze the reasons for the mismatch between forward and reverse typing of ABO blood types and the mismatch between cross matching.Methods When the forward and reverse typing do not match, use physiological saline method, polyamine method, anti human globulin method, and anti scree...

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Main Authors: Hongmei Qiu, Xuechun Wang, Yan Shao
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Hematology
Subjects:
Online Access:https://www.tandfonline.com/doi/10.1080/16078454.2023.2240146
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author Hongmei Qiu
Xuechun Wang
Yan Shao
author_facet Hongmei Qiu
Xuechun Wang
Yan Shao
author_sort Hongmei Qiu
collection DOAJ
description ABSTRACTObjective Analyze the reasons for the mismatch between forward and reverse typing of ABO blood types and the mismatch between cross matching.Methods When the forward and reverse typing do not match, use physiological saline method, polyamine method, anti human globulin method, and anti screening positive samples are used for antibody identification.Results The factors contributing to discrepancies in blood typing between forward and reverse typing include weakened serum typing, condensation, monoclonal immunoglobulin influence, bone marrow transplantation, and blood type subtypes. The causes of cross matching incompatibility include homologous antibody, warm Autoantibody, cold Autoantibody and daretozumab.Conclusion Regular red blood cell homologous antibody screening should be conducted based on disease type, blood transfusion history, and medication history. Antigen matched red blood cells should be selected for cross matching, and different experimental methods should be used for testing to ensure the safety of clinical blood transfusion.
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spelling doaj.art-15521e9e2c074483a70f114f5b4390492023-08-03T14:49:34ZengTaylor & Francis GroupHematology1607-84542023-12-0128110.1080/16078454.2023.2240146Forward and reverse typing discrepancy and crossmatch incompatibility of ABO blood groups: cause analysis and treatmentHongmei Qiu0Xuechun Wang1Yan Shao2Department of Blood Transfusion, The First Hospital of Jiaxing, Jiaxing, People’s Republic of ChinaDepartment of Blood Transfusion, The First Hospital of Jiaxing, Jiaxing, People’s Republic of ChinaDepartment of Laboratory, The Second People’s Hospital of Pinghu, Pinghu, People’s Republic of ChinaABSTRACTObjective Analyze the reasons for the mismatch between forward and reverse typing of ABO blood types and the mismatch between cross matching.Methods When the forward and reverse typing do not match, use physiological saline method, polyamine method, anti human globulin method, and anti screening positive samples are used for antibody identification.Results The factors contributing to discrepancies in blood typing between forward and reverse typing include weakened serum typing, condensation, monoclonal immunoglobulin influence, bone marrow transplantation, and blood type subtypes. The causes of cross matching incompatibility include homologous antibody, warm Autoantibody, cold Autoantibody and daretozumab.Conclusion Regular red blood cell homologous antibody screening should be conducted based on disease type, blood transfusion history, and medication history. Antigen matched red blood cells should be selected for cross matching, and different experimental methods should be used for testing to ensure the safety of clinical blood transfusion.https://www.tandfonline.com/doi/10.1080/16078454.2023.2240146Crossmatch incompatibilitydiscrepant forward and reverse blood group typing of ABO blood groupsinterfering factors
spellingShingle Hongmei Qiu
Xuechun Wang
Yan Shao
Forward and reverse typing discrepancy and crossmatch incompatibility of ABO blood groups: cause analysis and treatment
Hematology
Crossmatch incompatibility
discrepant forward and reverse blood group typing of ABO blood groups
interfering factors
title Forward and reverse typing discrepancy and crossmatch incompatibility of ABO blood groups: cause analysis and treatment
title_full Forward and reverse typing discrepancy and crossmatch incompatibility of ABO blood groups: cause analysis and treatment
title_fullStr Forward and reverse typing discrepancy and crossmatch incompatibility of ABO blood groups: cause analysis and treatment
title_full_unstemmed Forward and reverse typing discrepancy and crossmatch incompatibility of ABO blood groups: cause analysis and treatment
title_short Forward and reverse typing discrepancy and crossmatch incompatibility of ABO blood groups: cause analysis and treatment
title_sort forward and reverse typing discrepancy and crossmatch incompatibility of abo blood groups cause analysis and treatment
topic Crossmatch incompatibility
discrepant forward and reverse blood group typing of ABO blood groups
interfering factors
url https://www.tandfonline.com/doi/10.1080/16078454.2023.2240146
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AT xuechunwang forwardandreversetypingdiscrepancyandcrossmatchincompatibilityofabobloodgroupscauseanalysisandtreatment
AT yanshao forwardandreversetypingdiscrepancyandcrossmatchincompatibilityofabobloodgroupscauseanalysisandtreatment