Latent herpes simplex virus type 1 reactivation increases the susceptibility of neurodegenerative diseases: intervention with traditional Chinese medicine
Owing to environmental and lifestyle changes in modern society, physical and mental stress is on the rise among the population in attempting to compensate for the changes. Stress, defined as a series of non-specific responses to abnormal internal and external stimuli, has long been recognized to inc...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Compuscript Ltd
2022-12-01
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| Series: | Acta Materia Medica |
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| Online Access: | https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2022-0043 |
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| author | Jie Sun Chang-Yu Yan Jie Niu Ming-Hai Pan Zhuo Luo Wen-Jun Duan Wen Li Yan-Ping Wu Wan-Yang Sun Feng Huang Fan-Na Liu Hai-Zhi Liu Hiroshi Kurihara Yi-Fang Li Rong-Rong He |
| author_facet | Jie Sun Chang-Yu Yan Jie Niu Ming-Hai Pan Zhuo Luo Wen-Jun Duan Wen Li Yan-Ping Wu Wan-Yang Sun Feng Huang Fan-Na Liu Hai-Zhi Liu Hiroshi Kurihara Yi-Fang Li Rong-Rong He |
| author_sort | Jie Sun |
| collection | DOAJ |
| description | Owing to environmental and lifestyle changes in modern society, physical and mental stress is on the rise among the population in attempting to compensate for the changes. Stress, defined as a series of non-specific responses to abnormal internal and external stimuli, has long been recognized to increase susceptibility to various diseases, including neurodegenerative diseases (NDs). Herpes simplex virus type 1 (HSV-1), a neurotropic herpes virus, establishes latent infections in the trigeminal ganglia for the lifetime of the host. Upon reactivation, the latent HSV-1 enters the lytic cycle, which not only causes a substantial production of reactive oxygen species (ROS) in the neurons, but also induces glial cells to produce inflammatory mediators, eventually resulting in neuronal damage and occurrence of NDs. Remarkably, both physical and psychological stress are common stimuli leading to latent HSV-1 reactivation. Acyclovir is a classic antiviral drug for the treatment of HSV-1 infection and recurrence, but acyclovir cannot reverse neuronal damage caused by HSV-1 reactivation. Recent studies have shown that traditional Chinese medicine (TCM) has advantages in the treatment of NDs. In addition, TCM is thought to prevent latent HSV-1 reactivation and NDs, which may involve regulation of the neuro-endocrine-immune network, treatment of emotional disorders, and modulation of oxidative stress. Understanding the mechanism underlying stress-induced reactivation of latent HSV-1 and the potential consequences of NDs is needed. TCM may be a promising alternative therapy for related diseases. |
| first_indexed | 2024-03-11T21:51:07Z |
| format | Article |
| id | doaj.art-1552260c695c4f37b3d26a049f6ec27f |
| institution | Directory Open Access Journal |
| issn | 2737-7946 |
| language | English |
| last_indexed | 2024-03-11T21:51:07Z |
| publishDate | 2022-12-01 |
| publisher | Compuscript Ltd |
| record_format | Article |
| series | Acta Materia Medica |
| spelling | doaj.art-1552260c695c4f37b3d26a049f6ec27f2023-09-26T08:59:48ZengCompuscript LtdActa Materia Medica2737-79462022-12-011453455110.15212/AMM-2022-0043Latent herpes simplex virus type 1 reactivation increases the susceptibility of neurodegenerative diseases: intervention with traditional Chinese medicineJie Sun0Chang-Yu Yan1Jie Niu2Ming-Hai Pan3Zhuo Luo4Wen-Jun Duan5Wen Li6Yan-Ping Wu7Wan-Yang Sun8Feng Huang9Fan-Na Liu10Hai-Zhi Liu11Hiroshi Kurihara12Yi-Fang Li13Rong-Rong He14Guangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, Jinan University, Guangzhou 510632, ChinaGuangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, Jinan University, Guangzhou 510632, ChinaGuangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, Jinan University, Guangzhou 510632, ChinaGuangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, Jinan University, Guangzhou 510632, ChinaGuangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, Jinan University, Guangzhou 510632, ChinaGuangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, Jinan University, Guangzhou 510632, ChinaGuangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, Jinan University, Guangzhou 510632, ChinaGuangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, Jinan University, Guangzhou 510632, ChinaGuangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, Jinan University, Guangzhou 510632, ChinaSchool of Chinese Materia Medica and Yunnan Key Laboratory of Southern Medicinal Utilization, Yunnan University of Chinese Medicine, Kunming 650500, ChinaThe First Affiliated Hospital of Jinan University, Guangzhou 510632, ChinaThe First Affiliated Hospital of Jinan University, Guangzhou 510632, ChinaGuangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, Jinan University, Guangzhou 510632, ChinaGuangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, Jinan University, Guangzhou 510632, ChinaGuangdong Engineering Research Center of Chinese Medicine & Disease Susceptibility, Jinan University, Guangzhou 510632, ChinaOwing to environmental and lifestyle changes in modern society, physical and mental stress is on the rise among the population in attempting to compensate for the changes. Stress, defined as a series of non-specific responses to abnormal internal and external stimuli, has long been recognized to increase susceptibility to various diseases, including neurodegenerative diseases (NDs). Herpes simplex virus type 1 (HSV-1), a neurotropic herpes virus, establishes latent infections in the trigeminal ganglia for the lifetime of the host. Upon reactivation, the latent HSV-1 enters the lytic cycle, which not only causes a substantial production of reactive oxygen species (ROS) in the neurons, but also induces glial cells to produce inflammatory mediators, eventually resulting in neuronal damage and occurrence of NDs. Remarkably, both physical and psychological stress are common stimuli leading to latent HSV-1 reactivation. Acyclovir is a classic antiviral drug for the treatment of HSV-1 infection and recurrence, but acyclovir cannot reverse neuronal damage caused by HSV-1 reactivation. Recent studies have shown that traditional Chinese medicine (TCM) has advantages in the treatment of NDs. In addition, TCM is thought to prevent latent HSV-1 reactivation and NDs, which may involve regulation of the neuro-endocrine-immune network, treatment of emotional disorders, and modulation of oxidative stress. Understanding the mechanism underlying stress-induced reactivation of latent HSV-1 and the potential consequences of NDs is needed. TCM may be a promising alternative therapy for related diseases.https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2022-0043psychological stressneurodegenerative diseasesherpes simplex virus type 1latencyreactivationneuroendocrine systemimmunityneuroinflammationtraditional chinese medicine |
| spellingShingle | Jie Sun Chang-Yu Yan Jie Niu Ming-Hai Pan Zhuo Luo Wen-Jun Duan Wen Li Yan-Ping Wu Wan-Yang Sun Feng Huang Fan-Na Liu Hai-Zhi Liu Hiroshi Kurihara Yi-Fang Li Rong-Rong He Latent herpes simplex virus type 1 reactivation increases the susceptibility of neurodegenerative diseases: intervention with traditional Chinese medicine Acta Materia Medica psychological stress neurodegenerative diseases herpes simplex virus type 1 latency reactivation neuroendocrine system immunity neuroinflammation traditional chinese medicine |
| title | Latent herpes simplex virus type 1 reactivation increases the susceptibility of neurodegenerative diseases: intervention with traditional Chinese medicine |
| title_full | Latent herpes simplex virus type 1 reactivation increases the susceptibility of neurodegenerative diseases: intervention with traditional Chinese medicine |
| title_fullStr | Latent herpes simplex virus type 1 reactivation increases the susceptibility of neurodegenerative diseases: intervention with traditional Chinese medicine |
| title_full_unstemmed | Latent herpes simplex virus type 1 reactivation increases the susceptibility of neurodegenerative diseases: intervention with traditional Chinese medicine |
| title_short | Latent herpes simplex virus type 1 reactivation increases the susceptibility of neurodegenerative diseases: intervention with traditional Chinese medicine |
| title_sort | latent herpes simplex virus type 1 reactivation increases the susceptibility of neurodegenerative diseases intervention with traditional chinese medicine |
| topic | psychological stress neurodegenerative diseases herpes simplex virus type 1 latency reactivation neuroendocrine system immunity neuroinflammation traditional chinese medicine |
| url | https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2022-0043 |
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