Noninvasive In-Vivo Quantification of Mechanical Heterogeneity of Invasive Breast Carcinomas.
Heterogeneity is a hallmark of cancer whether one considers the genotype of cancerous cells, the composition of their microenvironment, the distribution of blood and lymphatic microvasculature, or the spatial distribution of the desmoplastic reaction. It is logical to expect that this heterogeneity...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2015-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4496079?pdf=render |
| _version_ | 1819278093091602432 |
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| author | Tengxiao Liu Olalekan A Babaniyi Timothy J Hall Paul E Barbone Assad A Oberai |
| author_facet | Tengxiao Liu Olalekan A Babaniyi Timothy J Hall Paul E Barbone Assad A Oberai |
| author_sort | Tengxiao Liu |
| collection | DOAJ |
| description | Heterogeneity is a hallmark of cancer whether one considers the genotype of cancerous cells, the composition of their microenvironment, the distribution of blood and lymphatic microvasculature, or the spatial distribution of the desmoplastic reaction. It is logical to expect that this heterogeneity in tumor microenvironment will lead to spatial heterogeneity in its mechanical properties. In this study we seek to quantify the mechanical heterogeneity within malignant and benign tumors using ultrasound based elasticity imaging. By creating in-vivo elastic modulus images for ten human subjects with breast tumors, we show that Young's modulus distribution in cancerous breast tumors is more heterogeneous when compared with tumors that are not malignant, and that this signature may be used to distinguish malignant breast tumors. Our results complement the view of cancer as a heterogeneous disease on multiple length scales by demonstrating that mechanical properties within cancerous tumors are also spatially heterogeneous. |
| first_indexed | 2024-12-24T00:06:31Z |
| format | Article |
| id | doaj.art-1553f1652fbc4e93b61383ac3318d984 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-12-24T00:06:31Z |
| publishDate | 2015-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-1553f1652fbc4e93b61383ac3318d9842022-12-21T17:25:00ZengPublic Library of Science (PLoS)PLoS ONE1932-62032015-01-01107e013025810.1371/journal.pone.0130258Noninvasive In-Vivo Quantification of Mechanical Heterogeneity of Invasive Breast Carcinomas.Tengxiao LiuOlalekan A BabaniyiTimothy J HallPaul E BarboneAssad A OberaiHeterogeneity is a hallmark of cancer whether one considers the genotype of cancerous cells, the composition of their microenvironment, the distribution of blood and lymphatic microvasculature, or the spatial distribution of the desmoplastic reaction. It is logical to expect that this heterogeneity in tumor microenvironment will lead to spatial heterogeneity in its mechanical properties. In this study we seek to quantify the mechanical heterogeneity within malignant and benign tumors using ultrasound based elasticity imaging. By creating in-vivo elastic modulus images for ten human subjects with breast tumors, we show that Young's modulus distribution in cancerous breast tumors is more heterogeneous when compared with tumors that are not malignant, and that this signature may be used to distinguish malignant breast tumors. Our results complement the view of cancer as a heterogeneous disease on multiple length scales by demonstrating that mechanical properties within cancerous tumors are also spatially heterogeneous.http://europepmc.org/articles/PMC4496079?pdf=render |
| spellingShingle | Tengxiao Liu Olalekan A Babaniyi Timothy J Hall Paul E Barbone Assad A Oberai Noninvasive In-Vivo Quantification of Mechanical Heterogeneity of Invasive Breast Carcinomas. PLoS ONE |
| title | Noninvasive In-Vivo Quantification of Mechanical Heterogeneity of Invasive Breast Carcinomas. |
| title_full | Noninvasive In-Vivo Quantification of Mechanical Heterogeneity of Invasive Breast Carcinomas. |
| title_fullStr | Noninvasive In-Vivo Quantification of Mechanical Heterogeneity of Invasive Breast Carcinomas. |
| title_full_unstemmed | Noninvasive In-Vivo Quantification of Mechanical Heterogeneity of Invasive Breast Carcinomas. |
| title_short | Noninvasive In-Vivo Quantification of Mechanical Heterogeneity of Invasive Breast Carcinomas. |
| title_sort | noninvasive in vivo quantification of mechanical heterogeneity of invasive breast carcinomas |
| url | http://europepmc.org/articles/PMC4496079?pdf=render |
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