Hot and cold tumors: Immunological features and the therapeutic strategies
Abstract The “hotness” or “coldness” of the tumors are determined by the information of the cancer cells themselves, tumor immune characteristics, tumor microenvironment, and signaling mechanisms, which are key factors affecting cancer patients’ clinical efficacy. The switch mechanism of “hotness” a...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-10-01
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| Series: | MedComm |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/mco2.343 |
| _version_ | 1797659159656660992 |
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| author | Lianjie Wang Hui Geng Yujie Liu Lei Liu Yanhua Chen Fanchen Wu Zhiyi Liu Shiliang Ling Yan Wang Lihong Zhou |
| author_facet | Lianjie Wang Hui Geng Yujie Liu Lei Liu Yanhua Chen Fanchen Wu Zhiyi Liu Shiliang Ling Yan Wang Lihong Zhou |
| author_sort | Lianjie Wang |
| collection | DOAJ |
| description | Abstract The “hotness” or “coldness” of the tumors are determined by the information of the cancer cells themselves, tumor immune characteristics, tumor microenvironment, and signaling mechanisms, which are key factors affecting cancer patients’ clinical efficacy. The switch mechanism of “hotness” and “coldness” and its corresponding pathological characteristics and treatment strategies are the frontier and hot spot of tumor treatment. How to distinguish the “hotness” or “coldness” effectively and clarify the causes, microenvironment state, and characteristics are very important for the tumor response and efficacy treatments. Starting from the concept of hot and cold tumor, this review systematically summarized the molecular characteristics, influencing factors, and therapeutic strategies of “hot and cold tumors,” and analyzed the immunophenotypes, the tumor microenvironment, the signaling pathways, and the molecular markers that contribute to “hot and cold tumors” in details. Different therapeutic strategies for “cold and hot tumors” based on clinical efficacy were analyzed with drug targets and proteins for “cold and hot tumors.” Furthermore, this review combines the therapeutic strategies of different “hot and cold tumors” with traditional medicine and modern medicine, to provide a basis and guidance for clinical decision‐making of cancer treatment. |
| first_indexed | 2024-03-11T18:09:50Z |
| format | Article |
| id | doaj.art-1553f24da21242699292bc2bf17eb533 |
| institution | Directory Open Access Journal |
| issn | 2688-2663 |
| language | English |
| last_indexed | 2024-03-11T18:09:50Z |
| publishDate | 2023-10-01 |
| publisher | Wiley |
| record_format | Article |
| series | MedComm |
| spelling | doaj.art-1553f24da21242699292bc2bf17eb5332023-10-16T15:20:40ZengWileyMedComm2688-26632023-10-0145n/an/a10.1002/mco2.343Hot and cold tumors: Immunological features and the therapeutic strategiesLianjie Wang0Hui Geng1Yujie Liu2Lei Liu3Yanhua Chen4Fanchen Wu5Zhiyi Liu6Shiliang Ling7Yan Wang8Lihong Zhou9Department of Medical Oncology and Cancer Institute Shuguang Hospital Shanghai University of Traditional Chinese Medicine ShanghaiChinaDepartment of Internal Medicine Shanghai International Medical Center ShanghaiChinaDepartment of Nephrology Shuguang Hospital Shanghai University of Traditional Chinese Medicine ShanghaiChinaDepartment of Medical Oncology and Cancer Institute Shuguang Hospital Shanghai University of Traditional Chinese Medicine ShanghaiChinaDepartment of the Tumor Research Center, Academy of Integrative Medicine Shanghai University of Traditional Chinese MedicineShanghaiChinaDepartment of Medical Oncology and Cancer Institute Shuguang Hospital Shanghai University of Traditional Chinese Medicine ShanghaiChinaDepartment of Medical Oncology and Cancer Institute Shuguang Hospital Shanghai University of Traditional Chinese Medicine ShanghaiChinaDepartment of Medical Oncology Ningbo Hospital of Traditional Chinese Medicine, Zhejiang Province NingboChinaDepartment of Medical Oncology and Cancer Institute Shuguang Hospital Shanghai University of Traditional Chinese Medicine ShanghaiChinaDepartment of Medical Oncology and Cancer Institute Shuguang Hospital Shanghai University of Traditional Chinese Medicine ShanghaiChinaAbstract The “hotness” or “coldness” of the tumors are determined by the information of the cancer cells themselves, tumor immune characteristics, tumor microenvironment, and signaling mechanisms, which are key factors affecting cancer patients’ clinical efficacy. The switch mechanism of “hotness” and “coldness” and its corresponding pathological characteristics and treatment strategies are the frontier and hot spot of tumor treatment. How to distinguish the “hotness” or “coldness” effectively and clarify the causes, microenvironment state, and characteristics are very important for the tumor response and efficacy treatments. Starting from the concept of hot and cold tumor, this review systematically summarized the molecular characteristics, influencing factors, and therapeutic strategies of “hot and cold tumors,” and analyzed the immunophenotypes, the tumor microenvironment, the signaling pathways, and the molecular markers that contribute to “hot and cold tumors” in details. Different therapeutic strategies for “cold and hot tumors” based on clinical efficacy were analyzed with drug targets and proteins for “cold and hot tumors.” Furthermore, this review combines the therapeutic strategies of different “hot and cold tumors” with traditional medicine and modern medicine, to provide a basis and guidance for clinical decision‐making of cancer treatment.https://doi.org/10.1002/mco2.343cancerhotness and coldness of tumorsimmune characteristicssignaling mechanismtherapeutic strategiestumor microenvironment |
| spellingShingle | Lianjie Wang Hui Geng Yujie Liu Lei Liu Yanhua Chen Fanchen Wu Zhiyi Liu Shiliang Ling Yan Wang Lihong Zhou Hot and cold tumors: Immunological features and the therapeutic strategies MedComm cancer hotness and coldness of tumors immune characteristics signaling mechanism therapeutic strategies tumor microenvironment |
| title | Hot and cold tumors: Immunological features and the therapeutic strategies |
| title_full | Hot and cold tumors: Immunological features and the therapeutic strategies |
| title_fullStr | Hot and cold tumors: Immunological features and the therapeutic strategies |
| title_full_unstemmed | Hot and cold tumors: Immunological features and the therapeutic strategies |
| title_short | Hot and cold tumors: Immunological features and the therapeutic strategies |
| title_sort | hot and cold tumors immunological features and the therapeutic strategies |
| topic | cancer hotness and coldness of tumors immune characteristics signaling mechanism therapeutic strategies tumor microenvironment |
| url | https://doi.org/10.1002/mco2.343 |
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