Abatacept reduces disease activity of rheumatoid arthritis independently of modulating anti-citrullinated peptide antibody production
Abatacept may exert its clinical effect on rheumatoid arthritis (RA) by suppressing anti-cyclic citrullinated peptide (CCP) antibody production. This study was undertaken to test this hypothesis by examining the changes of disease activity of RA and anti-CCP antibody levels over time after starting...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2020-04-01
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| Series: | Immunological Medicine |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/25785826.2020.1718833 |
| _version_ | 1818502026945888256 |
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| author | Hisakata Yamada Tomomi Tsuru Takeshi Otsuka Masayuki Maekawa Hiroshi Harada Takaaki Fukuda Hiroshi Tsukamoto Akira Maeyama Shigeru Yoshizawa Ken Wada Yasuharu Nakashima Eisuke Shono Seiji Yoshizawa Hiroshi Jojima Masakazu Kondo |
| author_facet | Hisakata Yamada Tomomi Tsuru Takeshi Otsuka Masayuki Maekawa Hiroshi Harada Takaaki Fukuda Hiroshi Tsukamoto Akira Maeyama Shigeru Yoshizawa Ken Wada Yasuharu Nakashima Eisuke Shono Seiji Yoshizawa Hiroshi Jojima Masakazu Kondo |
| author_sort | Hisakata Yamada |
| collection | DOAJ |
| description | Abatacept may exert its clinical effect on rheumatoid arthritis (RA) by suppressing anti-cyclic citrullinated peptide (CCP) antibody production. This study was undertaken to test this hypothesis by examining the changes of disease activity of RA and anti-CCP antibody levels over time after starting abatacept. Sixty Japanese RA patients who started abatacept were included in this multicenter, prospective observational study. Simple Disease Activity Index (SDAI) and anti-CCP antibody levels were evaluated at 12, 24, and 52 weeks. The mean SDAI score significantly decreased within 12 weeks after starting abatacept and was maintained thereafter. On the contrary, the mean anti-CCP antibody levels did not change until 52 weeks. At the individual level, there were substantial changes of anti-CCP antibody levels, but these were not correlated with the changes of disease activity at any time points. Thus, abatacept reduces the disease activity of RA independently of modulating anti-CCP antibody production. |
| first_indexed | 2024-12-10T21:04:18Z |
| format | Article |
| id | doaj.art-1555dbb760624871b88689878032cfb0 |
| institution | Directory Open Access Journal |
| issn | 2578-5826 |
| language | English |
| last_indexed | 2024-12-10T21:04:18Z |
| publishDate | 2020-04-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Immunological Medicine |
| spelling | doaj.art-1555dbb760624871b88689878032cfb02022-12-22T01:33:41ZengTaylor & Francis GroupImmunological Medicine2578-58262020-04-01432879110.1080/25785826.2020.17188331718833Abatacept reduces disease activity of rheumatoid arthritis independently of modulating anti-citrullinated peptide antibody productionHisakata Yamada0Tomomi Tsuru1Takeshi Otsuka2Masayuki Maekawa3Hiroshi Harada4Takaaki Fukuda5Hiroshi Tsukamoto6Akira Maeyama7Shigeru Yoshizawa8Ken Wada9Yasuharu Nakashima10Eisuke Shono11Seiji Yoshizawa12Hiroshi Jojima13Masakazu Kondo14Kyushu UniversityPS ClinicMunakata Medical Association HospitalMaekawa Clinic of Rheumatology and Orthopedic SurgeryMorooka Orthopedic ClinicKurume University Medical CenterKyushu UniversityFukuoka UniversityNational Hospital Organization Fukuoka HospitalWada Orthopaedic ClinicKyushu UniversityShono Rheumatology ClinicHamanomachi HospitalFukuoka University Chikushi HospitalKondo Clinic of Rheumatology and Orthopaedic SurgeryAbatacept may exert its clinical effect on rheumatoid arthritis (RA) by suppressing anti-cyclic citrullinated peptide (CCP) antibody production. This study was undertaken to test this hypothesis by examining the changes of disease activity of RA and anti-CCP antibody levels over time after starting abatacept. Sixty Japanese RA patients who started abatacept were included in this multicenter, prospective observational study. Simple Disease Activity Index (SDAI) and anti-CCP antibody levels were evaluated at 12, 24, and 52 weeks. The mean SDAI score significantly decreased within 12 weeks after starting abatacept and was maintained thereafter. On the contrary, the mean anti-CCP antibody levels did not change until 52 weeks. At the individual level, there were substantial changes of anti-CCP antibody levels, but these were not correlated with the changes of disease activity at any time points. Thus, abatacept reduces the disease activity of RA independently of modulating anti-CCP antibody production.http://dx.doi.org/10.1080/25785826.2020.1718833rheumatoid arthritisanti-citrullinated protein antibodiescyclic citrullinated peptideabatacept |
| spellingShingle | Hisakata Yamada Tomomi Tsuru Takeshi Otsuka Masayuki Maekawa Hiroshi Harada Takaaki Fukuda Hiroshi Tsukamoto Akira Maeyama Shigeru Yoshizawa Ken Wada Yasuharu Nakashima Eisuke Shono Seiji Yoshizawa Hiroshi Jojima Masakazu Kondo Abatacept reduces disease activity of rheumatoid arthritis independently of modulating anti-citrullinated peptide antibody production Immunological Medicine rheumatoid arthritis anti-citrullinated protein antibodies cyclic citrullinated peptide abatacept |
| title | Abatacept reduces disease activity of rheumatoid arthritis independently of modulating anti-citrullinated peptide antibody production |
| title_full | Abatacept reduces disease activity of rheumatoid arthritis independently of modulating anti-citrullinated peptide antibody production |
| title_fullStr | Abatacept reduces disease activity of rheumatoid arthritis independently of modulating anti-citrullinated peptide antibody production |
| title_full_unstemmed | Abatacept reduces disease activity of rheumatoid arthritis independently of modulating anti-citrullinated peptide antibody production |
| title_short | Abatacept reduces disease activity of rheumatoid arthritis independently of modulating anti-citrullinated peptide antibody production |
| title_sort | abatacept reduces disease activity of rheumatoid arthritis independently of modulating anti citrullinated peptide antibody production |
| topic | rheumatoid arthritis anti-citrullinated protein antibodies cyclic citrullinated peptide abatacept |
| url | http://dx.doi.org/10.1080/25785826.2020.1718833 |
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