Cutaneous vasculitis and vasculopathy in the era of COVID-19 pandemic
Cutaneous vasculitides encompass a heterogeneous group of clinicopathological entities, which may occur as single-organ vasculitis of the skin or present as skin-limited variant of systemic vasculitis (i.e., skin-limited ANCA-associated vasculitis), and are triggered by various factors, including in...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2022-08-01
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| Series: | Frontiers in Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmed.2022.996288/full |
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| author | Carlo Alberto Maronese Carlo Alberto Maronese Enrico Zelin Gianluca Avallone Chiara Moltrasio Chiara Moltrasio Maurizio Romagnuolo Maurizio Romagnuolo Simone Ribero Pietro Quaglino Angelo Valerio Marzano Angelo Valerio Marzano |
| author_facet | Carlo Alberto Maronese Carlo Alberto Maronese Enrico Zelin Gianluca Avallone Chiara Moltrasio Chiara Moltrasio Maurizio Romagnuolo Maurizio Romagnuolo Simone Ribero Pietro Quaglino Angelo Valerio Marzano Angelo Valerio Marzano |
| author_sort | Carlo Alberto Maronese |
| collection | DOAJ |
| description | Cutaneous vasculitides encompass a heterogeneous group of clinicopathological entities, which may occur as single-organ vasculitis of the skin or present as skin-limited variant of systemic vasculitis (i.e., skin-limited ANCA-associated vasculitis), and are triggered by various factors, including infections, drugs and vaccines. The COVID-19 pandemic has challenged us with a variety of both disease- and vaccine-associated skin manifestations, including vasculitis. Among the latter, cutaneous small-vessel vasculitis, previously known as leukocytoclastic vasculitis, seems to be the most reported in either scenario, i.e., natural infection and vaccination. Vasculopathy without true vasculitic changes on histology develops in but a minority of cases, mostly severe/critical COVID-19 patients, and appears to be the result of endothelial injury due to pauci-immune thromboembolic mechanisms. Herein, we provide an overview of the available literature on COVID-19-associated and anti-SARS-CoV-2-vaccine-associated cutaneous vasculitis. Although evidence is mostly limited to isolated reports, with a proportion of cases lacking histopathological confirmation, ample overlap with pre-pandemic forms is shown. |
| first_indexed | 2024-12-11T00:44:42Z |
| format | Article |
| id | doaj.art-15584902b3ae42059c6973e1c0f70099 |
| institution | Directory Open Access Journal |
| issn | 2296-858X |
| language | English |
| last_indexed | 2024-12-11T00:44:42Z |
| publishDate | 2022-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Medicine |
| spelling | doaj.art-15584902b3ae42059c6973e1c0f700992022-12-22T01:26:49ZengFrontiers Media S.A.Frontiers in Medicine2296-858X2022-08-01910.3389/fmed.2022.996288996288Cutaneous vasculitis and vasculopathy in the era of COVID-19 pandemicCarlo Alberto Maronese0Carlo Alberto Maronese1Enrico Zelin2Gianluca Avallone3Chiara Moltrasio4Chiara Moltrasio5Maurizio Romagnuolo6Maurizio Romagnuolo7Simone Ribero8Pietro Quaglino9Angelo Valerio Marzano10Angelo Valerio Marzano11Dermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, ItalyDepartment of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, ItalyDermatology Clinic, Maggiore Hospital, University of Trieste, Trieste, ItalyDermatology Clinic, Department of Medical Sciences, University of Turin, Turin, ItalyDermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, ItalyDepartment of Medical Surgical and Health Sciences, University of Trieste, Trieste, ItalyDermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, ItalyDepartment of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, ItalyDermatology Clinic, Department of Medical Sciences, University of Turin, Turin, ItalyDermatology Clinic, Department of Medical Sciences, University of Turin, Turin, ItalyDermatology Unit, Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico, Milan, ItalyDepartment of Pathophysiology and Transplantation, Università degli Studi di Milano, Milan, ItalyCutaneous vasculitides encompass a heterogeneous group of clinicopathological entities, which may occur as single-organ vasculitis of the skin or present as skin-limited variant of systemic vasculitis (i.e., skin-limited ANCA-associated vasculitis), and are triggered by various factors, including infections, drugs and vaccines. The COVID-19 pandemic has challenged us with a variety of both disease- and vaccine-associated skin manifestations, including vasculitis. Among the latter, cutaneous small-vessel vasculitis, previously known as leukocytoclastic vasculitis, seems to be the most reported in either scenario, i.e., natural infection and vaccination. Vasculopathy without true vasculitic changes on histology develops in but a minority of cases, mostly severe/critical COVID-19 patients, and appears to be the result of endothelial injury due to pauci-immune thromboembolic mechanisms. Herein, we provide an overview of the available literature on COVID-19-associated and anti-SARS-CoV-2-vaccine-associated cutaneous vasculitis. Although evidence is mostly limited to isolated reports, with a proportion of cases lacking histopathological confirmation, ample overlap with pre-pandemic forms is shown.https://www.frontiersin.org/articles/10.3389/fmed.2022.996288/fullvasculitisvasculopathyCOVID-19COVID vaccinescutaneous manifestation |
| spellingShingle | Carlo Alberto Maronese Carlo Alberto Maronese Enrico Zelin Gianluca Avallone Chiara Moltrasio Chiara Moltrasio Maurizio Romagnuolo Maurizio Romagnuolo Simone Ribero Pietro Quaglino Angelo Valerio Marzano Angelo Valerio Marzano Cutaneous vasculitis and vasculopathy in the era of COVID-19 pandemic Frontiers in Medicine vasculitis vasculopathy COVID-19 COVID vaccines cutaneous manifestation |
| title | Cutaneous vasculitis and vasculopathy in the era of COVID-19 pandemic |
| title_full | Cutaneous vasculitis and vasculopathy in the era of COVID-19 pandemic |
| title_fullStr | Cutaneous vasculitis and vasculopathy in the era of COVID-19 pandemic |
| title_full_unstemmed | Cutaneous vasculitis and vasculopathy in the era of COVID-19 pandemic |
| title_short | Cutaneous vasculitis and vasculopathy in the era of COVID-19 pandemic |
| title_sort | cutaneous vasculitis and vasculopathy in the era of covid 19 pandemic |
| topic | vasculitis vasculopathy COVID-19 COVID vaccines cutaneous manifestation |
| url | https://www.frontiersin.org/articles/10.3389/fmed.2022.996288/full |
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