Cellular heterogeneity and plasticity during NAFLD progression
Nonalcoholic fatty liver disease (NAFLD) is a progressive liver disease that can progress to nonalcoholic steatohepatitis (NASH), NASH-related cirrhosis, and hepatocellular carcinoma (HCC). NAFLD ranges from simple steatosis (or nonalcoholic fatty liver [NAFL]) to NASH as a progressive form of NAFL,...
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| Format: | Article |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Molecular Biosciences |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmolb.2023.1221669/full |
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| author | Hyun-Ju Park Hyun-Ju Park Juyong Choi Juyong Choi Hyunmi Kim Hyunmi Kim Da-Yeon Yang Da-Yeon Yang Tae Hyeon An Tae Hyeon An Eun-Woo Lee Eun-Woo Lee Baek-Soo Han Baek-Soo Han Sang Chul Lee Sang Chul Lee Won Kon Kim Won Kon Kim Kwang-Hee Bae Kwang-Hee Bae Kyoung-Jin Oh Kyoung-Jin Oh |
| author_facet | Hyun-Ju Park Hyun-Ju Park Juyong Choi Juyong Choi Hyunmi Kim Hyunmi Kim Da-Yeon Yang Da-Yeon Yang Tae Hyeon An Tae Hyeon An Eun-Woo Lee Eun-Woo Lee Baek-Soo Han Baek-Soo Han Sang Chul Lee Sang Chul Lee Won Kon Kim Won Kon Kim Kwang-Hee Bae Kwang-Hee Bae Kyoung-Jin Oh Kyoung-Jin Oh |
| author_sort | Hyun-Ju Park |
| collection | DOAJ |
| description | Nonalcoholic fatty liver disease (NAFLD) is a progressive liver disease that can progress to nonalcoholic steatohepatitis (NASH), NASH-related cirrhosis, and hepatocellular carcinoma (HCC). NAFLD ranges from simple steatosis (or nonalcoholic fatty liver [NAFL]) to NASH as a progressive form of NAFL, which is characterized by steatosis, lobular inflammation, and hepatocellular ballooning with or without fibrosis. Because of the complex pathophysiological mechanism and the heterogeneity of NAFLD, including its wide spectrum of clinical and histological characteristics, no specific therapeutic drugs have been approved for NAFLD. The heterogeneity of NAFLD is closely associated with cellular plasticity, which describes the ability of cells to acquire new identities or change their phenotypes in response to environmental stimuli. The liver consists of parenchymal cells including hepatocytes and cholangiocytes and nonparenchymal cells including Kupffer cells, hepatic stellate cells, and endothelial cells, all of which have specialized functions. This heterogeneous cell population has cellular plasticity to adapt to environmental changes. During NAFLD progression, these cells can exert diverse and complex responses at multiple levels following exposure to a variety of stimuli, including fatty acids, inflammation, and oxidative stress. Therefore, this review provides insights into NAFLD heterogeneity by addressing the cellular plasticity and metabolic adaptation of hepatocytes, cholangiocytes, hepatic stellate cells, and Kupffer cells during NAFLD progression. |
| first_indexed | 2024-03-12T15:13:42Z |
| format | Article |
| id | doaj.art-1558977ee33d496d887d5e81baca706d |
| institution | Directory Open Access Journal |
| issn | 2296-889X |
| language | English |
| last_indexed | 2025-02-18T14:13:04Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
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| series | Frontiers in Molecular Biosciences |
| spelling | doaj.art-1558977ee33d496d887d5e81baca706d2024-10-28T09:24:07ZengFrontiers Media S.A.Frontiers in Molecular Biosciences2296-889X2023-08-011010.3389/fmolb.2023.12216691221669Cellular heterogeneity and plasticity during NAFLD progressionHyun-Ju Park0Hyun-Ju Park1Juyong Choi2Juyong Choi3Hyunmi Kim4Hyunmi Kim5Da-Yeon Yang6Da-Yeon Yang7Tae Hyeon An8Tae Hyeon An9Eun-Woo Lee10Eun-Woo Lee11Baek-Soo Han12Baek-Soo Han13Sang Chul Lee14Sang Chul Lee15Won Kon Kim16Won Kon Kim17Kwang-Hee Bae18Kwang-Hee Bae19Kyoung-Jin Oh20Kyoung-Jin Oh21Metabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of KoreaDepartment of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology (UST), Daejeon, Republic of KoreaMetabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of KoreaDepartment of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology (UST), Daejeon, Republic of KoreaMetabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of KoreaDepartment of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology (UST), Daejeon, Republic of KoreaMetabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of KoreaDepartment of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology (UST), Daejeon, Republic of KoreaMetabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of KoreaDepartment of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology (UST), Daejeon, Republic of KoreaMetabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of KoreaDepartment of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology (UST), Daejeon, Republic of KoreaDepartment of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology (UST), Daejeon, Republic of KoreaBiodefense Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of KoreaMetabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of KoreaDepartment of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology (UST), Daejeon, Republic of KoreaMetabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of KoreaDepartment of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology (UST), Daejeon, Republic of KoreaMetabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of KoreaDepartment of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology (UST), Daejeon, Republic of KoreaMetabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejeon, Republic of KoreaDepartment of Functional Genomics, KRIBB School of Bioscience, University of Science and Technology (UST), Daejeon, Republic of KoreaNonalcoholic fatty liver disease (NAFLD) is a progressive liver disease that can progress to nonalcoholic steatohepatitis (NASH), NASH-related cirrhosis, and hepatocellular carcinoma (HCC). NAFLD ranges from simple steatosis (or nonalcoholic fatty liver [NAFL]) to NASH as a progressive form of NAFL, which is characterized by steatosis, lobular inflammation, and hepatocellular ballooning with or without fibrosis. Because of the complex pathophysiological mechanism and the heterogeneity of NAFLD, including its wide spectrum of clinical and histological characteristics, no specific therapeutic drugs have been approved for NAFLD. The heterogeneity of NAFLD is closely associated with cellular plasticity, which describes the ability of cells to acquire new identities or change their phenotypes in response to environmental stimuli. The liver consists of parenchymal cells including hepatocytes and cholangiocytes and nonparenchymal cells including Kupffer cells, hepatic stellate cells, and endothelial cells, all of which have specialized functions. This heterogeneous cell population has cellular plasticity to adapt to environmental changes. During NAFLD progression, these cells can exert diverse and complex responses at multiple levels following exposure to a variety of stimuli, including fatty acids, inflammation, and oxidative stress. Therefore, this review provides insights into NAFLD heterogeneity by addressing the cellular plasticity and metabolic adaptation of hepatocytes, cholangiocytes, hepatic stellate cells, and Kupffer cells during NAFLD progression.https://www.frontiersin.org/articles/10.3389/fmolb.2023.1221669/fullNAFLDheterogeneityhepatocytesCholangiocyteshepatic stellate cellsKupffer cells |
| spellingShingle | Hyun-Ju Park Hyun-Ju Park Juyong Choi Juyong Choi Hyunmi Kim Hyunmi Kim Da-Yeon Yang Da-Yeon Yang Tae Hyeon An Tae Hyeon An Eun-Woo Lee Eun-Woo Lee Baek-Soo Han Baek-Soo Han Sang Chul Lee Sang Chul Lee Won Kon Kim Won Kon Kim Kwang-Hee Bae Kwang-Hee Bae Kyoung-Jin Oh Kyoung-Jin Oh Cellular heterogeneity and plasticity during NAFLD progression Frontiers in Molecular Biosciences NAFLD heterogeneity hepatocytes Cholangiocytes hepatic stellate cells Kupffer cells |
| title | Cellular heterogeneity and plasticity during NAFLD progression |
| title_full | Cellular heterogeneity and plasticity during NAFLD progression |
| title_fullStr | Cellular heterogeneity and plasticity during NAFLD progression |
| title_full_unstemmed | Cellular heterogeneity and plasticity during NAFLD progression |
| title_short | Cellular heterogeneity and plasticity during NAFLD progression |
| title_sort | cellular heterogeneity and plasticity during nafld progression |
| topic | NAFLD heterogeneity hepatocytes Cholangiocytes hepatic stellate cells Kupffer cells |
| url | https://www.frontiersin.org/articles/10.3389/fmolb.2023.1221669/full |
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