Growth-Inhibitory Effect of Chitosan-Coated Liposomes Encapsulating Curcumin on MCF-7 Breast Cancer Cells
Current anticancer drugs exhibit limited efficacy and initiate severe side effects. As such, identifying bioactive anticancer agents that can surpass these limitations is a necessity. One such agent, curcumin, is a polyphenolic compound derived from turmeric, and has been widely investigated for its...
| Main Authors: | , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-04-01
|
| Series: | Marine Drugs |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1660-3397/18/4/217 |
| _version_ | 1797570293719367680 |
|---|---|
| author | Mahmoud Hasan Kamil Elkhoury Nabila Belhaj Cyril Kahn Ali Tamayol Muriel Barberi-Heyob Elmira Arab-Tehrany Michel Linder |
| author_facet | Mahmoud Hasan Kamil Elkhoury Nabila Belhaj Cyril Kahn Ali Tamayol Muriel Barberi-Heyob Elmira Arab-Tehrany Michel Linder |
| author_sort | Mahmoud Hasan |
| collection | DOAJ |
| description | Current anticancer drugs exhibit limited efficacy and initiate severe side effects. As such, identifying bioactive anticancer agents that can surpass these limitations is a necessity. One such agent, curcumin, is a polyphenolic compound derived from turmeric, and has been widely investigated for its potential anti-inflammatory and anticancer effects over the last 40 years. However, the poor bioavailability of curcumin, caused by its low absorption, limits its clinical use. In order to solve this issue, in this study, curcumin was encapsulated in chitosan-coated nanoliposomes derived from three natural lecithin sources. Liposomal formulations were all in the nanometric scale (around 120 nm) and negatively charged (around −40 mV). Among the three lecithins, salmon lecithin presented the highest growth-inhibitory effect on MCF-7 cells (two times lower growth than the control group for 12 µM of curcumin and four times lower for 20 µM of curcumin). The soya and rapeseed lecithins showed a similar growth-inhibitory effect on the tumor cells. Moreover, coating nanoliposomes with chitosan enabled a higher loading efficiency of curcumin (88% for coated liposomes compared to 65% for the non-coated liposomes) and a stronger growth-inhibitory effect on MCF-7 breast cancer cells. |
| first_indexed | 2024-03-10T20:23:52Z |
| format | Article |
| id | doaj.art-155953b14c494da99368bf4ae55d5135 |
| institution | Directory Open Access Journal |
| issn | 1660-3397 |
| language | English |
| last_indexed | 2024-03-10T20:23:52Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Marine Drugs |
| spelling | doaj.art-155953b14c494da99368bf4ae55d51352023-11-19T21:57:17ZengMDPI AGMarine Drugs1660-33972020-04-0118421710.3390/md18040217Growth-Inhibitory Effect of Chitosan-Coated Liposomes Encapsulating Curcumin on MCF-7 Breast Cancer CellsMahmoud Hasan0Kamil Elkhoury1Nabila Belhaj2Cyril Kahn3Ali Tamayol4Muriel Barberi-Heyob5Elmira Arab-Tehrany6Michel Linder7LIBio, Université de Lorraine, F-54000 Nancy, FranceLIBio, Université de Lorraine, F-54000 Nancy, FranceLIBio, Université de Lorraine, F-54000 Nancy, FranceLIBio, Université de Lorraine, F-54000 Nancy, FranceDepartment of Biomedical Engineering, University of Connecticut, Storrs, CT 06269, USACRAN, Université de Lorraine, CNRS, F-54000 Nancy, FranceLIBio, Université de Lorraine, F-54000 Nancy, FranceLIBio, Université de Lorraine, F-54000 Nancy, FranceCurrent anticancer drugs exhibit limited efficacy and initiate severe side effects. As such, identifying bioactive anticancer agents that can surpass these limitations is a necessity. One such agent, curcumin, is a polyphenolic compound derived from turmeric, and has been widely investigated for its potential anti-inflammatory and anticancer effects over the last 40 years. However, the poor bioavailability of curcumin, caused by its low absorption, limits its clinical use. In order to solve this issue, in this study, curcumin was encapsulated in chitosan-coated nanoliposomes derived from three natural lecithin sources. Liposomal formulations were all in the nanometric scale (around 120 nm) and negatively charged (around −40 mV). Among the three lecithins, salmon lecithin presented the highest growth-inhibitory effect on MCF-7 cells (two times lower growth than the control group for 12 µM of curcumin and four times lower for 20 µM of curcumin). The soya and rapeseed lecithins showed a similar growth-inhibitory effect on the tumor cells. Moreover, coating nanoliposomes with chitosan enabled a higher loading efficiency of curcumin (88% for coated liposomes compared to 65% for the non-coated liposomes) and a stronger growth-inhibitory effect on MCF-7 breast cancer cells.https://www.mdpi.com/1660-3397/18/4/217breast cancerMCF-7liposomesencapsulationchitosancurcumin |
| spellingShingle | Mahmoud Hasan Kamil Elkhoury Nabila Belhaj Cyril Kahn Ali Tamayol Muriel Barberi-Heyob Elmira Arab-Tehrany Michel Linder Growth-Inhibitory Effect of Chitosan-Coated Liposomes Encapsulating Curcumin on MCF-7 Breast Cancer Cells Marine Drugs breast cancer MCF-7 liposomes encapsulation chitosan curcumin |
| title | Growth-Inhibitory Effect of Chitosan-Coated Liposomes Encapsulating Curcumin on MCF-7 Breast Cancer Cells |
| title_full | Growth-Inhibitory Effect of Chitosan-Coated Liposomes Encapsulating Curcumin on MCF-7 Breast Cancer Cells |
| title_fullStr | Growth-Inhibitory Effect of Chitosan-Coated Liposomes Encapsulating Curcumin on MCF-7 Breast Cancer Cells |
| title_full_unstemmed | Growth-Inhibitory Effect of Chitosan-Coated Liposomes Encapsulating Curcumin on MCF-7 Breast Cancer Cells |
| title_short | Growth-Inhibitory Effect of Chitosan-Coated Liposomes Encapsulating Curcumin on MCF-7 Breast Cancer Cells |
| title_sort | growth inhibitory effect of chitosan coated liposomes encapsulating curcumin on mcf 7 breast cancer cells |
| topic | breast cancer MCF-7 liposomes encapsulation chitosan curcumin |
| url | https://www.mdpi.com/1660-3397/18/4/217 |
| work_keys_str_mv | AT mahmoudhasan growthinhibitoryeffectofchitosancoatedliposomesencapsulatingcurcuminonmcf7breastcancercells AT kamilelkhoury growthinhibitoryeffectofchitosancoatedliposomesencapsulatingcurcuminonmcf7breastcancercells AT nabilabelhaj growthinhibitoryeffectofchitosancoatedliposomesencapsulatingcurcuminonmcf7breastcancercells AT cyrilkahn growthinhibitoryeffectofchitosancoatedliposomesencapsulatingcurcuminonmcf7breastcancercells AT alitamayol growthinhibitoryeffectofchitosancoatedliposomesencapsulatingcurcuminonmcf7breastcancercells AT murielbarberiheyob growthinhibitoryeffectofchitosancoatedliposomesencapsulatingcurcuminonmcf7breastcancercells AT elmiraarabtehrany growthinhibitoryeffectofchitosancoatedliposomesencapsulatingcurcuminonmcf7breastcancercells AT michellinder growthinhibitoryeffectofchitosancoatedliposomesencapsulatingcurcuminonmcf7breastcancercells |