Antioxidant potential of bitter cumin (<it>Centratherum anthelminticum </it>(L.) Kuntze) seeds in <it>in vitro </it>models
<p>Abstract</p> <p>Background</p> <p>Bitter cumin (<it>Centratherum anthelminticum </it>(L.) Kuntze), is a medicinally important plant. Earlier, we have reported phenolic compounds, antioxidant, and anti-hyperglycemic, antimicrobial activity of bitter cumin....
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| Format: | Article |
| Language: | English |
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BMC
2011-05-01
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| Series: | BMC Complementary and Alternative Medicine |
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| Online Access: | http://www.biomedcentral.com/1472-6882/11/40 |
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| author | Naidu Kamatham A Ani V |
| author_facet | Naidu Kamatham A Ani V |
| author_sort | Naidu Kamatham A |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Bitter cumin (<it>Centratherum anthelminticum </it>(L.) Kuntze), is a medicinally important plant. Earlier, we have reported phenolic compounds, antioxidant, and anti-hyperglycemic, antimicrobial activity of bitter cumin. In this study we have further characterized the antioxidative activity of bitter cumin extracts in various in vitro models.</p> <p>Methods</p> <p>Bitter cumin seeds were extracted with a combination of acetone, methanol and water. The antioxidant activity of bitter cumin extracts were characterized in various <it>in vitro </it>model systems such as DPPH radical, ABTS radical scavenging, reducing power, oxidation of liposomes and oxidative damage to DNA.</p> <p>Results</p> <p>The phenolic extracts of bitter cumin at microgram concentration showed significant scavenging of DPPH and ABTS radicals, reduced phosphomolybdenum (Mo(VI) to Mo(V)), ferricyanide Fe(III) to Fe(II), inhibited liposomes oxidation and hydroxyl radical induced damage to prokaryotic genomic DNA. The results showed a direct correlation between phenolic acid content and antioxidant activity.</p> <p>Conclusion</p> <p>Bitter cumin is a good source of natural antioxidants.</p> |
| first_indexed | 2024-04-14T03:53:14Z |
| format | Article |
| id | doaj.art-155d38c6cb0044deb780e2ef2ae4b28b |
| institution | Directory Open Access Journal |
| issn | 1472-6882 |
| language | English |
| last_indexed | 2024-04-14T03:53:14Z |
| publishDate | 2011-05-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Complementary and Alternative Medicine |
| spelling | doaj.art-155d38c6cb0044deb780e2ef2ae4b28b2022-12-22T02:13:57ZengBMCBMC Complementary and Alternative Medicine1472-68822011-05-011114010.1186/1472-6882-11-40Antioxidant potential of bitter cumin (<it>Centratherum anthelminticum </it>(L.) Kuntze) seeds in <it>in vitro </it>modelsNaidu Kamatham AAni V<p>Abstract</p> <p>Background</p> <p>Bitter cumin (<it>Centratherum anthelminticum </it>(L.) Kuntze), is a medicinally important plant. Earlier, we have reported phenolic compounds, antioxidant, and anti-hyperglycemic, antimicrobial activity of bitter cumin. In this study we have further characterized the antioxidative activity of bitter cumin extracts in various in vitro models.</p> <p>Methods</p> <p>Bitter cumin seeds were extracted with a combination of acetone, methanol and water. The antioxidant activity of bitter cumin extracts were characterized in various <it>in vitro </it>model systems such as DPPH radical, ABTS radical scavenging, reducing power, oxidation of liposomes and oxidative damage to DNA.</p> <p>Results</p> <p>The phenolic extracts of bitter cumin at microgram concentration showed significant scavenging of DPPH and ABTS radicals, reduced phosphomolybdenum (Mo(VI) to Mo(V)), ferricyanide Fe(III) to Fe(II), inhibited liposomes oxidation and hydroxyl radical induced damage to prokaryotic genomic DNA. The results showed a direct correlation between phenolic acid content and antioxidant activity.</p> <p>Conclusion</p> <p>Bitter cumin is a good source of natural antioxidants.</p>http://www.biomedcentral.com/1472-6882/11/40Bitter cumin<it>Centratherum anthelminticum</it>polyphenolic compoundsantioxidantsDPPHABTSreducing powerliposomesoxidative DNA damage |
| spellingShingle | Naidu Kamatham A Ani V Antioxidant potential of bitter cumin (<it>Centratherum anthelminticum </it>(L.) Kuntze) seeds in <it>in vitro </it>models BMC Complementary and Alternative Medicine Bitter cumin <it>Centratherum anthelminticum</it> polyphenolic compounds antioxidants DPPH ABTS reducing power liposomes oxidative DNA damage |
| title | Antioxidant potential of bitter cumin (<it>Centratherum anthelminticum </it>(L.) Kuntze) seeds in <it>in vitro </it>models |
| title_full | Antioxidant potential of bitter cumin (<it>Centratherum anthelminticum </it>(L.) Kuntze) seeds in <it>in vitro </it>models |
| title_fullStr | Antioxidant potential of bitter cumin (<it>Centratherum anthelminticum </it>(L.) Kuntze) seeds in <it>in vitro </it>models |
| title_full_unstemmed | Antioxidant potential of bitter cumin (<it>Centratherum anthelminticum </it>(L.) Kuntze) seeds in <it>in vitro </it>models |
| title_short | Antioxidant potential of bitter cumin (<it>Centratherum anthelminticum </it>(L.) Kuntze) seeds in <it>in vitro </it>models |
| title_sort | antioxidant potential of bitter cumin it centratherum anthelminticum it l kuntze seeds in it in vitro it models |
| topic | Bitter cumin <it>Centratherum anthelminticum</it> polyphenolic compounds antioxidants DPPH ABTS reducing power liposomes oxidative DNA damage |
| url | http://www.biomedcentral.com/1472-6882/11/40 |
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