Biomedical Implants with Charge‐Transfer Monitoring and Regulating Abilities
Abstract Transmembrane charge (ion/electron) transfer is essential for maintaining cellular homeostasis and is involved in many biological processes, from protein synthesis to embryonic development in organisms. Designing implant devices that can detect or regulate cellular transmembrane charge tran...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-08-01
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| Series: | Advanced Science |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/advs.202004393 |
| _version_ | 1818639709389193216 |
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| author | Donghui Wang Ji Tan Hongqin Zhu Yongfeng Mei Xuanyong Liu |
| author_facet | Donghui Wang Ji Tan Hongqin Zhu Yongfeng Mei Xuanyong Liu |
| author_sort | Donghui Wang |
| collection | DOAJ |
| description | Abstract Transmembrane charge (ion/electron) transfer is essential for maintaining cellular homeostasis and is involved in many biological processes, from protein synthesis to embryonic development in organisms. Designing implant devices that can detect or regulate cellular transmembrane charge transfer is expected to sense and modulate the behaviors of host cells and tissues. Thus, charge transfer can be regarded as a bridge connecting living systems and human‐made implantable devices. This review describes the mode and mechanism of charge transfer between organisms and nonliving materials, and summarizes the strategies to endow implants with charge‐transfer regulating or monitoring abilities. Furthermore, three major charge‐transfer controlling systems, including wired, self‐activated, and stimuli‐responsive biomedical implants, as well as the design principles and pivotal materials are systematically elaborated. The clinical challenges and the prospects for future development of these implant devices are also discussed. |
| first_indexed | 2024-12-16T22:59:41Z |
| format | Article |
| id | doaj.art-155dbda26e6748c595ebef72282e9b96 |
| institution | Directory Open Access Journal |
| issn | 2198-3844 |
| language | English |
| last_indexed | 2024-12-16T22:59:41Z |
| publishDate | 2021-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Advanced Science |
| spelling | doaj.art-155dbda26e6748c595ebef72282e9b962022-12-21T22:12:46ZengWileyAdvanced Science2198-38442021-08-01816n/an/a10.1002/advs.202004393Biomedical Implants with Charge‐Transfer Monitoring and Regulating AbilitiesDonghui Wang0Ji Tan1Hongqin Zhu2Yongfeng Mei3Xuanyong Liu4State Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institutes of Ceramics Chinese Academy of Sciences Shanghai 200050 ChinaState Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institutes of Ceramics Chinese Academy of Sciences Shanghai 200050 ChinaState Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institutes of Ceramics Chinese Academy of Sciences Shanghai 200050 ChinaDepartment of Materials Science Fudan University Shanghai 200433 ChinaState Key Laboratory of High Performance Ceramics and Superfine Microstructure Shanghai Institutes of Ceramics Chinese Academy of Sciences Shanghai 200050 ChinaAbstract Transmembrane charge (ion/electron) transfer is essential for maintaining cellular homeostasis and is involved in many biological processes, from protein synthesis to embryonic development in organisms. Designing implant devices that can detect or regulate cellular transmembrane charge transfer is expected to sense and modulate the behaviors of host cells and tissues. Thus, charge transfer can be regarded as a bridge connecting living systems and human‐made implantable devices. This review describes the mode and mechanism of charge transfer between organisms and nonliving materials, and summarizes the strategies to endow implants with charge‐transfer regulating or monitoring abilities. Furthermore, three major charge‐transfer controlling systems, including wired, self‐activated, and stimuli‐responsive biomedical implants, as well as the design principles and pivotal materials are systematically elaborated. The clinical challenges and the prospects for future development of these implant devices are also discussed.https://doi.org/10.1002/advs.202004393bioelectronicscell behaviorcharge transferelectronbiomedical implantion |
| spellingShingle | Donghui Wang Ji Tan Hongqin Zhu Yongfeng Mei Xuanyong Liu Biomedical Implants with Charge‐Transfer Monitoring and Regulating Abilities Advanced Science bioelectronics cell behavior charge transfer electron biomedical implant ion |
| title | Biomedical Implants with Charge‐Transfer Monitoring and Regulating Abilities |
| title_full | Biomedical Implants with Charge‐Transfer Monitoring and Regulating Abilities |
| title_fullStr | Biomedical Implants with Charge‐Transfer Monitoring and Regulating Abilities |
| title_full_unstemmed | Biomedical Implants with Charge‐Transfer Monitoring and Regulating Abilities |
| title_short | Biomedical Implants with Charge‐Transfer Monitoring and Regulating Abilities |
| title_sort | biomedical implants with charge transfer monitoring and regulating abilities |
| topic | bioelectronics cell behavior charge transfer electron biomedical implant ion |
| url | https://doi.org/10.1002/advs.202004393 |
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