Hepatocellular carcinoma diagnosed in a patient who had Fontan operation 30 years ago: a case report
The Fontan operation is performed in patients with a single ventricle. As the systemic venous return is directly connected to the pulmonary circulation during this procedure, chronic hepatic congestion is induced, leading to Fontan-associated liver disease (FALD) including liver cirrhosis and hepato...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Korean Liver Cancer Association
2022-09-01
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| Series: | Journal of Liver Cancer |
| Subjects: | |
| Online Access: | http://www.e-jlc.org/upload/pdf/jlc-2022-08-17.pdf |
| _version_ | 1811177792528711680 |
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| author | Moon Haeng Hur Haeryoung Kim Jeong-Hoon Lee |
| author_facet | Moon Haeng Hur Haeryoung Kim Jeong-Hoon Lee |
| author_sort | Moon Haeng Hur |
| collection | DOAJ |
| description | The Fontan operation is performed in patients with a single ventricle. As the systemic venous return is directly connected to the pulmonary circulation during this procedure, chronic hepatic congestion is induced, leading to Fontan-associated liver disease (FALD) including liver cirrhosis and hepatocellular carcinoma (HCC). In this report, we present a case of HCC diagnosed in a patient who underwent the Fontan operation 30 years ago. The patient underwent regular surveillance for FALD, which revealed a 4 cm-sized hepatic mass with elevated serum alpha-fetoprotein. After surgical treatment, there was no evidence of HCC recurrence during 3 years of follow-up. As the risk of HCC and Fontan-associated liver cirrhosis increases with the duration elapsed since the operation, regular surveillance should be emphasized. Serial follow-up of serum alpha-fetoprotein levels and abdominal imaging are necessary to achieve early and accurate diagnosis of HCC in post-Fontan patients. |
| first_indexed | 2024-04-11T06:08:16Z |
| format | Article |
| id | doaj.art-1560362ccf734563b83714df4b65ba1e |
| institution | Directory Open Access Journal |
| issn | 2288-8128 2383-5001 |
| language | English |
| last_indexed | 2024-04-11T06:08:16Z |
| publishDate | 2022-09-01 |
| publisher | Korean Liver Cancer Association |
| record_format | Article |
| series | Journal of Liver Cancer |
| spelling | doaj.art-1560362ccf734563b83714df4b65ba1e2022-12-22T04:41:26ZengKorean Liver Cancer AssociationJournal of Liver Cancer2288-81282383-50012022-09-0122218819310.17998/jlc.2022.08.17504Hepatocellular carcinoma diagnosed in a patient who had Fontan operation 30 years ago: a case reportMoon Haeng Hur0Haeryoung Kim1Jeong-Hoon Lee2 Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, Korea Department of Pathology, Seoul National University College of Medicine, Seoul, Korea Department of Internal Medicine and Liver Research Institute, Seoul National University College of Medicine, Seoul, KoreaThe Fontan operation is performed in patients with a single ventricle. As the systemic venous return is directly connected to the pulmonary circulation during this procedure, chronic hepatic congestion is induced, leading to Fontan-associated liver disease (FALD) including liver cirrhosis and hepatocellular carcinoma (HCC). In this report, we present a case of HCC diagnosed in a patient who underwent the Fontan operation 30 years ago. The patient underwent regular surveillance for FALD, which revealed a 4 cm-sized hepatic mass with elevated serum alpha-fetoprotein. After surgical treatment, there was no evidence of HCC recurrence during 3 years of follow-up. As the risk of HCC and Fontan-associated liver cirrhosis increases with the duration elapsed since the operation, regular surveillance should be emphasized. Serial follow-up of serum alpha-fetoprotein levels and abdominal imaging are necessary to achieve early and accurate diagnosis of HCC in post-Fontan patients.http://www.e-jlc.org/upload/pdf/jlc-2022-08-17.pdfliver cancerfontan operationfontan-associated liver diseasecase report |
| spellingShingle | Moon Haeng Hur Haeryoung Kim Jeong-Hoon Lee Hepatocellular carcinoma diagnosed in a patient who had Fontan operation 30 years ago: a case report Journal of Liver Cancer liver cancer fontan operation fontan-associated liver disease case report |
| title | Hepatocellular carcinoma diagnosed in a patient who had Fontan operation 30 years ago: a case report |
| title_full | Hepatocellular carcinoma diagnosed in a patient who had Fontan operation 30 years ago: a case report |
| title_fullStr | Hepatocellular carcinoma diagnosed in a patient who had Fontan operation 30 years ago: a case report |
| title_full_unstemmed | Hepatocellular carcinoma diagnosed in a patient who had Fontan operation 30 years ago: a case report |
| title_short | Hepatocellular carcinoma diagnosed in a patient who had Fontan operation 30 years ago: a case report |
| title_sort | hepatocellular carcinoma diagnosed in a patient who had fontan operation 30 years ago a case report |
| topic | liver cancer fontan operation fontan-associated liver disease case report |
| url | http://www.e-jlc.org/upload/pdf/jlc-2022-08-17.pdf |
| work_keys_str_mv | AT moonhaenghur hepatocellularcarcinomadiagnosedinapatientwhohadfontanoperation30yearsagoacasereport AT haeryoungkim hepatocellularcarcinomadiagnosedinapatientwhohadfontanoperation30yearsagoacasereport AT jeonghoonlee hepatocellularcarcinomadiagnosedinapatientwhohadfontanoperation30yearsagoacasereport |