The Role of Non-Gaussian Models of Diffusion Weighted MRI in Hepatocellular Carcinoma: A Systematic Review
The importance of Diffusion Weighted Imaging (DWI) in hepatocellular carcinoma (HCC) has been widely handled in the literature. Due to the mono-exponential model limitations, several studies recently investigated the role of non-Gaussian DWI models in HCC. However, their results are variable and inc...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/10/12/2641 |
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| author | Liberatore Tramontano Carlo Cavaliere Marco Salvatore Valentina Brancato |
| author_facet | Liberatore Tramontano Carlo Cavaliere Marco Salvatore Valentina Brancato |
| author_sort | Liberatore Tramontano |
| collection | DOAJ |
| description | The importance of Diffusion Weighted Imaging (DWI) in hepatocellular carcinoma (HCC) has been widely handled in the literature. Due to the mono-exponential model limitations, several studies recently investigated the role of non-Gaussian DWI models in HCC. However, their results are variable and inconsistent. Therefore, the aim of this systematic review is to summarize current knowledge on non-Gaussian DWI techniques in HCC. A systematic search of the literature, including PubMed, Google Scholar, MEDLINE, and ScienceDirect databases, was performed to identify original articles since 2010 that evaluated the role of non-Gaussian DWI models for HCC diagnosis, grading, response to treatment, and prognosis. Studies were grouped and summarized according to the non-Gaussian DWI models investigated. We focused on the most used non-Gaussian DWI models (Intravoxel Incoherent Motion (IVIM), Diffusion Kurtosis Imaging (DKI), and Stretched Exponential—SE). The quality of included studies was evaluated by using QUADAS-2 and QUIPS tools. Forty-three articles were included, with IVIM and DKI being the most investigated models. Although the role of non-Gaussian DWI models in clinical settings has not fully been established, our findings showed that their parameters may potentially play a role in HCC. Further studies are required to identify a standardized DWI acquisition protocol for HCC diagnosis, grading, response to treatment, and prognosis. |
| first_indexed | 2024-03-10T10:22:09Z |
| format | Article |
| id | doaj.art-15624bfaef2546d2831a4a98fdb08668 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T10:22:09Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-15624bfaef2546d2831a4a98fdb086682023-11-22T00:16:25ZengMDPI AGJournal of Clinical Medicine2077-03832021-06-011012264110.3390/jcm10122641The Role of Non-Gaussian Models of Diffusion Weighted MRI in Hepatocellular Carcinoma: A Systematic ReviewLiberatore Tramontano0Carlo Cavaliere1Marco Salvatore2Valentina Brancato3IRCCS SDN, 80143 Naples, ItalyIRCCS SDN, 80143 Naples, ItalyIRCCS SDN, 80143 Naples, ItalyIRCCS SDN, 80143 Naples, ItalyThe importance of Diffusion Weighted Imaging (DWI) in hepatocellular carcinoma (HCC) has been widely handled in the literature. Due to the mono-exponential model limitations, several studies recently investigated the role of non-Gaussian DWI models in HCC. However, their results are variable and inconsistent. Therefore, the aim of this systematic review is to summarize current knowledge on non-Gaussian DWI techniques in HCC. A systematic search of the literature, including PubMed, Google Scholar, MEDLINE, and ScienceDirect databases, was performed to identify original articles since 2010 that evaluated the role of non-Gaussian DWI models for HCC diagnosis, grading, response to treatment, and prognosis. Studies were grouped and summarized according to the non-Gaussian DWI models investigated. We focused on the most used non-Gaussian DWI models (Intravoxel Incoherent Motion (IVIM), Diffusion Kurtosis Imaging (DKI), and Stretched Exponential—SE). The quality of included studies was evaluated by using QUADAS-2 and QUIPS tools. Forty-three articles were included, with IVIM and DKI being the most investigated models. Although the role of non-Gaussian DWI models in clinical settings has not fully been established, our findings showed that their parameters may potentially play a role in HCC. Further studies are required to identify a standardized DWI acquisition protocol for HCC diagnosis, grading, response to treatment, and prognosis.https://www.mdpi.com/2077-0383/10/12/2641hepatocellular carcinomamagnetic resonance imagingdiffusion weighted MRInon-Gaussian DWIIntravoxel Incoherent MotionDiffusion Kurtosis Imaging |
| spellingShingle | Liberatore Tramontano Carlo Cavaliere Marco Salvatore Valentina Brancato The Role of Non-Gaussian Models of Diffusion Weighted MRI in Hepatocellular Carcinoma: A Systematic Review Journal of Clinical Medicine hepatocellular carcinoma magnetic resonance imaging diffusion weighted MRI non-Gaussian DWI Intravoxel Incoherent Motion Diffusion Kurtosis Imaging |
| title | The Role of Non-Gaussian Models of Diffusion Weighted MRI in Hepatocellular Carcinoma: A Systematic Review |
| title_full | The Role of Non-Gaussian Models of Diffusion Weighted MRI in Hepatocellular Carcinoma: A Systematic Review |
| title_fullStr | The Role of Non-Gaussian Models of Diffusion Weighted MRI in Hepatocellular Carcinoma: A Systematic Review |
| title_full_unstemmed | The Role of Non-Gaussian Models of Diffusion Weighted MRI in Hepatocellular Carcinoma: A Systematic Review |
| title_short | The Role of Non-Gaussian Models of Diffusion Weighted MRI in Hepatocellular Carcinoma: A Systematic Review |
| title_sort | role of non gaussian models of diffusion weighted mri in hepatocellular carcinoma a systematic review |
| topic | hepatocellular carcinoma magnetic resonance imaging diffusion weighted MRI non-Gaussian DWI Intravoxel Incoherent Motion Diffusion Kurtosis Imaging |
| url | https://www.mdpi.com/2077-0383/10/12/2641 |
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