Effects of chronically high levels of aldosterone on different cognitive dimensions: an investigation in patients with primary aldosteronism
Primary aldosteronism is a natural model for chronic aldosterone excess in humans and associated with symptoms of anxiety and depression. Cognitive deficits are inherent to the symptomatology of depression and anxiety disorders. Mineralocorticoid receptors and aldosterone appear to play a role in me...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Bioscientifica
2019-04-01
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| Series: | Endocrine Connections |
| Subjects: | |
| Online Access: | https://ec.bioscientifica.com/view/journals/ec/8/4/EC-19-0043.xml |
| _version_ | 1818479991594156032 |
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| author | Lukas Engler Christian Adolf Daniel A Heinrich Anna-Katharine Brem Anna Riester Anna Franke Felix Beuschlein Martin Reincke Axel Steiger Heike Künzel |
| author_facet | Lukas Engler Christian Adolf Daniel A Heinrich Anna-Katharine Brem Anna Riester Anna Franke Felix Beuschlein Martin Reincke Axel Steiger Heike Künzel |
| author_sort | Lukas Engler |
| collection | DOAJ |
| description | Primary aldosteronism is a natural model for chronic aldosterone excess in humans and associated with symptoms of anxiety and depression. Cognitive deficits are inherent to the symptomatology of depression and anxiety disorders. Mineralocorticoid receptors and aldosterone appear to play a role in memory. Aldosterone was additionally supposed to be a risk factor for cognitive decline in patients with essential hypertension. The objective of this study was to investigate possible effects of chronically high aldosterone concentrations on cognitive function. A range of cognitive dimensions were assessed in 19 patients (9 males, 10 females); mean age 47.1 (12.5) under standardized treatment and several rating scales for anxiety, depression, quality of life and sleep were administered. Cognitive parameters were compared to standard norms from a large, healthy standardization sample. Patients showed increased levels of anxiety and depression without meeting diagnostic criteria for a disorder. Besides a numerically lower attention score, patients did not show any significant differences in the cognitive dimensions. Anxiety and depression were negatively correlated with quantitative performance in males. In females, a negative correlation between sleep disturbances and abstract reasoning and a positive correlation with quantitative performance were found. Our data showed no specific effect of chronic aldosterone in the tested cognitive parameters overall at least in younger patients, but they indicate sexually dimorphic regulation processes. |
| first_indexed | 2024-12-10T11:17:10Z |
| format | Article |
| id | doaj.art-1563e55b1a2e43118e0368c2f518d2c9 |
| institution | Directory Open Access Journal |
| issn | 2049-3614 2049-3614 |
| language | English |
| last_indexed | 2024-12-10T11:17:10Z |
| publishDate | 2019-04-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Connections |
| spelling | doaj.art-1563e55b1a2e43118e0368c2f518d2c92022-12-22T01:51:06ZengBioscientificaEndocrine Connections2049-36142049-36142019-04-0184407415https://doi.org/10.1530/EC-19-0043Effects of chronically high levels of aldosterone on different cognitive dimensions: an investigation in patients with primary aldosteronismLukas Engler0Christian Adolf1Daniel A Heinrich2Anna-Katharine Brem3Anna Riester4Anna Franke5Felix Beuschlein6Martin Reincke7Axel Steiger8Heike Künzel9Medizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU München, Munchen, GermanyMedizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU München, Munchen, GermanyMedizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU München, Munchen, GermanyMax-Planck-Institute of Psychiatry, Munich, Germany; Division of Interventional Cognitive Neurology, Department of Neurology, Berenson-Allen Center for Noninvasive Brain Stimulation, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, Massachusetts, USAMedizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU München, Munchen, GermanyMedizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU München, Munchen, GermanyMedizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU München, Munchen, GermanyMedizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU München, Munchen, GermanyMax-Planck-Institute of Psychiatry, Munich, GermanyMedizinische Klinik und Poliklinik IV, Klinikum der Universität München, LMU München, Munchen, GermanyPrimary aldosteronism is a natural model for chronic aldosterone excess in humans and associated with symptoms of anxiety and depression. Cognitive deficits are inherent to the symptomatology of depression and anxiety disorders. Mineralocorticoid receptors and aldosterone appear to play a role in memory. Aldosterone was additionally supposed to be a risk factor for cognitive decline in patients with essential hypertension. The objective of this study was to investigate possible effects of chronically high aldosterone concentrations on cognitive function. A range of cognitive dimensions were assessed in 19 patients (9 males, 10 females); mean age 47.1 (12.5) under standardized treatment and several rating scales for anxiety, depression, quality of life and sleep were administered. Cognitive parameters were compared to standard norms from a large, healthy standardization sample. Patients showed increased levels of anxiety and depression without meeting diagnostic criteria for a disorder. Besides a numerically lower attention score, patients did not show any significant differences in the cognitive dimensions. Anxiety and depression were negatively correlated with quantitative performance in males. In females, a negative correlation between sleep disturbances and abstract reasoning and a positive correlation with quantitative performance were found. Our data showed no specific effect of chronic aldosterone in the tested cognitive parameters overall at least in younger patients, but they indicate sexually dimorphic regulation processes.https://ec.bioscientifica.com/view/journals/ec/8/4/EC-19-0043.xmlaldosteronecognitionanxietydepressionprimary aldosteronismmineralocorticoid receptor |
| spellingShingle | Lukas Engler Christian Adolf Daniel A Heinrich Anna-Katharine Brem Anna Riester Anna Franke Felix Beuschlein Martin Reincke Axel Steiger Heike Künzel Effects of chronically high levels of aldosterone on different cognitive dimensions: an investigation in patients with primary aldosteronism Endocrine Connections aldosterone cognition anxiety depression primary aldosteronism mineralocorticoid receptor |
| title | Effects of chronically high levels of aldosterone on different cognitive dimensions: an investigation in patients with primary aldosteronism |
| title_full | Effects of chronically high levels of aldosterone on different cognitive dimensions: an investigation in patients with primary aldosteronism |
| title_fullStr | Effects of chronically high levels of aldosterone on different cognitive dimensions: an investigation in patients with primary aldosteronism |
| title_full_unstemmed | Effects of chronically high levels of aldosterone on different cognitive dimensions: an investigation in patients with primary aldosteronism |
| title_short | Effects of chronically high levels of aldosterone on different cognitive dimensions: an investigation in patients with primary aldosteronism |
| title_sort | effects of chronically high levels of aldosterone on different cognitive dimensions an investigation in patients with primary aldosteronism |
| topic | aldosterone cognition anxiety depression primary aldosteronism mineralocorticoid receptor |
| url | https://ec.bioscientifica.com/view/journals/ec/8/4/EC-19-0043.xml |
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