From systems biology to P4 medicine: applications in respiratory medicine
Human health and disease are emergent properties of a complex, nonlinear, dynamic multilevel biological system: the human body. Systems biology is a comprehensive research strategy that has the potential to understand these emergent properties holistically. It stems from advancements in medical diag...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
European Respiratory Society
2018-02-01
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| Series: | European Respiratory Review |
| Online Access: | http://err.ersjournals.com/content/27/147/170110.full |
| _version_ | 1811325938823069696 |
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| author | Guillaume Noell Rosa Faner Alvar Agustí |
| author_facet | Guillaume Noell Rosa Faner Alvar Agustí |
| author_sort | Guillaume Noell |
| collection | DOAJ |
| description | Human health and disease are emergent properties of a complex, nonlinear, dynamic multilevel biological system: the human body. Systems biology is a comprehensive research strategy that has the potential to understand these emergent properties holistically. It stems from advancements in medical diagnostics, “omics” data and bioinformatic computing power. It paves the way forward towards “P4 medicine” (predictive, preventive, personalised and participatory), which seeks to better intervene preventively to preserve health or therapeutically to cure diseases. In this review, we: 1) discuss the principles of systems biology; 2) elaborate on how P4 medicine has the potential to shift healthcare from reactive medicine (treatment of illness) to predict and prevent illness, in a revolution that will be personalised in nature, probabilistic in essence and participatory driven; 3) review the current state of the art of network (systems) medicine in three prevalent respiratory diseases (chronic obstructive pulmonary disease, asthma and lung cancer); and 4) outline current challenges and future goals in the field. |
| first_indexed | 2024-04-13T14:41:16Z |
| format | Article |
| id | doaj.art-1563e6d9b8234c468eb2fa8156ea854a |
| institution | Directory Open Access Journal |
| issn | 0905-9180 1600-0617 |
| language | English |
| last_indexed | 2024-04-13T14:41:16Z |
| publishDate | 2018-02-01 |
| publisher | European Respiratory Society |
| record_format | Article |
| series | European Respiratory Review |
| spelling | doaj.art-1563e6d9b8234c468eb2fa8156ea854a2022-12-22T02:42:53ZengEuropean Respiratory SocietyEuropean Respiratory Review0905-91801600-06172018-02-012714710.1183/16000617.0110-20170110-2017From systems biology to P4 medicine: applications in respiratory medicineGuillaume Noell0Rosa Faner1Alvar Agustí2 Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain Institut d'Investigacions Biomediques August Pi i Sunyer (IDIBAPS), Barcelona, Spain Human health and disease are emergent properties of a complex, nonlinear, dynamic multilevel biological system: the human body. Systems biology is a comprehensive research strategy that has the potential to understand these emergent properties holistically. It stems from advancements in medical diagnostics, “omics” data and bioinformatic computing power. It paves the way forward towards “P4 medicine” (predictive, preventive, personalised and participatory), which seeks to better intervene preventively to preserve health or therapeutically to cure diseases. In this review, we: 1) discuss the principles of systems biology; 2) elaborate on how P4 medicine has the potential to shift healthcare from reactive medicine (treatment of illness) to predict and prevent illness, in a revolution that will be personalised in nature, probabilistic in essence and participatory driven; 3) review the current state of the art of network (systems) medicine in three prevalent respiratory diseases (chronic obstructive pulmonary disease, asthma and lung cancer); and 4) outline current challenges and future goals in the field.http://err.ersjournals.com/content/27/147/170110.full |
| spellingShingle | Guillaume Noell Rosa Faner Alvar Agustí From systems biology to P4 medicine: applications in respiratory medicine European Respiratory Review |
| title | From systems biology to P4 medicine: applications in respiratory medicine |
| title_full | From systems biology to P4 medicine: applications in respiratory medicine |
| title_fullStr | From systems biology to P4 medicine: applications in respiratory medicine |
| title_full_unstemmed | From systems biology to P4 medicine: applications in respiratory medicine |
| title_short | From systems biology to P4 medicine: applications in respiratory medicine |
| title_sort | from systems biology to p4 medicine applications in respiratory medicine |
| url | http://err.ersjournals.com/content/27/147/170110.full |
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