Methylene Blue to Treat Protamine-induced Anaphylaxis Reactions. An Experimental Study in Pigs

Methylene Blue to Treat Protamine-induced Anaphylaxis Reactions. An Experimental Study in Pigs

ABSTRACT Objective: To examine if methylene blue (MB) can counteract or prevent protamine (P) cardiovascular effects. Methods: The protocol included five heparinized pig groups: Group Sham -without any drug; Group MB - MB 3 mg/kg infusion; Group P - protamine; Group P/MB - MB after protamine; Grou...

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Main Authors: Agnes Afrodite S. Albuquerque, Edson A. Margarido, Antonio Carlos Menardi, Adilson Scorzoni Filho, Andrea Carla Celotto, Alfredo J. Rodrigues, Walter Vilella A. Vicente, Paulo Roberto B. Evora
Format: Article
Language:English
Published: Sociedade Brasileira de Cirurgia Cardiovascular
Series:Brazilian Journal of Cardiovascular Surgery
Subjects:
Protamines
Nitric Oxide
Methylene Blue
Anaphylaxis
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-76382016000300226&lng=en&tlng=en

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