Sodium Alginate with PEG/PEO Blends as a Floating Drug Delivery Carrier – In vitro Evaluation
Purpose: Floating drug delivery system reduces the quantity of drug intake and the risk of overloading the organs with excess drug. Methods: In the present study, we prepared the blends of sodium alginate with polyethylene glycol (PEG) and polyethylene oxide (PEO) as a matrix, sodium hydrogen carbon...
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| Format: | Article |
| Language: | English |
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Tabriz University of Medical Sciences
2016-09-01
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| Series: | Advanced Pharmaceutical Bulletin |
| Subjects: |
| _version_ | 1828267189139931136 |
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| author | Christe Sonia Mary Sasikumar Swamiappan |
| author_facet | Christe Sonia Mary Sasikumar Swamiappan |
| author_sort | Christe Sonia Mary |
| collection | DOAJ |
| description | Purpose: Floating drug delivery system reduces the quantity of drug intake and the risk of overloading the organs with excess drug. Methods: In the present study, we prepared the blends of sodium alginate with polyethylene glycol (PEG) and polyethylene oxide (PEO) as a matrix, sodium hydrogen carbonate as a pore forming agent, methyl cellulose as a binder and barium chloride containing 10% acetic acid as a hardening agent. Different ratios of pore forming agent to the polymer blend was used to prepare the floating beads with different porosity and morphology. Ciprofloxacin hydrochloride was used as a model drug for the release kinetics studies. Results: The beads were characterized by optical and FESEM microscopy to study the morphology and pore dimensions. The results obtained shows decrease in beads size with increase in the concentration of the pore forming agent. The swelling properties of the beads were found to be in the range of 80% to 125%. The release kinetics of the ciprofloxacin from the beads was measured by UV-Visible spectroscopy at λmax of 278nm and the results shows for highly porous beads. Conclusion: By varying the amount of alginate and pore forming agent the release kinetics is found to get altered. As a result, ciprofloxacin hydrochloride release is found to be sustained from the blended beads. |
| first_indexed | 2024-04-13T05:01:23Z |
| format | Article |
| id | doaj.art-1566ad4b506641fdbb62766fea61639f |
| institution | Directory Open Access Journal |
| issn | 2228-5881 2251-7308 |
| language | English |
| last_indexed | 2024-04-13T05:01:23Z |
| publishDate | 2016-09-01 |
| publisher | Tabriz University of Medical Sciences |
| record_format | Article |
| series | Advanced Pharmaceutical Bulletin |
| spelling | doaj.art-1566ad4b506641fdbb62766fea61639f2022-12-22T03:01:18ZengTabriz University of Medical SciencesAdvanced Pharmaceutical Bulletin2228-58812251-73082016-09-016343544210.15171/apb.2016.056APB_843_20160616221928Sodium Alginate with PEG/PEO Blends as a Floating Drug Delivery Carrier – In vitro EvaluationChriste Sonia Mary0Sasikumar Swamiappan1Department of Chemistry, School of Advanced Sciences, VIT University, Vellore-632014, Tamil Nadu, India.Department of Chemistry, School of Advanced Sciences, VIT University, Vellore-632014, Tamil Nadu, India.Purpose: Floating drug delivery system reduces the quantity of drug intake and the risk of overloading the organs with excess drug. Methods: In the present study, we prepared the blends of sodium alginate with polyethylene glycol (PEG) and polyethylene oxide (PEO) as a matrix, sodium hydrogen carbonate as a pore forming agent, methyl cellulose as a binder and barium chloride containing 10% acetic acid as a hardening agent. Different ratios of pore forming agent to the polymer blend was used to prepare the floating beads with different porosity and morphology. Ciprofloxacin hydrochloride was used as a model drug for the release kinetics studies. Results: The beads were characterized by optical and FESEM microscopy to study the morphology and pore dimensions. The results obtained shows decrease in beads size with increase in the concentration of the pore forming agent. The swelling properties of the beads were found to be in the range of 80% to 125%. The release kinetics of the ciprofloxacin from the beads was measured by UV-Visible spectroscopy at λmax of 278nm and the results shows for highly porous beads. Conclusion: By varying the amount of alginate and pore forming agent the release kinetics is found to get altered. As a result, ciprofloxacin hydrochloride release is found to be sustained from the blended beads.Ciprofloxacin hydrochlorideFloating drug delivery systemPolyethylene glycolPolyethylene oxideSodium alginateSodium bicarbonate |
| spellingShingle | Christe Sonia Mary Sasikumar Swamiappan Sodium Alginate with PEG/PEO Blends as a Floating Drug Delivery Carrier – In vitro Evaluation Advanced Pharmaceutical Bulletin Ciprofloxacin hydrochloride Floating drug delivery system Polyethylene glycol Polyethylene oxide Sodium alginate Sodium bicarbonate |
| title | Sodium Alginate with PEG/PEO Blends as a Floating Drug Delivery Carrier – In vitro Evaluation |
| title_full | Sodium Alginate with PEG/PEO Blends as a Floating Drug Delivery Carrier – In vitro Evaluation |
| title_fullStr | Sodium Alginate with PEG/PEO Blends as a Floating Drug Delivery Carrier – In vitro Evaluation |
| title_full_unstemmed | Sodium Alginate with PEG/PEO Blends as a Floating Drug Delivery Carrier – In vitro Evaluation |
| title_short | Sodium Alginate with PEG/PEO Blends as a Floating Drug Delivery Carrier – In vitro Evaluation |
| title_sort | sodium alginate with peg peo blends as a floating drug delivery carrier in vitro evaluation |
| topic | Ciprofloxacin hydrochloride Floating drug delivery system Polyethylene glycol Polyethylene oxide Sodium alginate Sodium bicarbonate |
| work_keys_str_mv | AT christesoniamary sodiumalginatewithpegpeoblendsasafloatingdrugdeliverycarrierinvitroevaluation AT sasikumarswamiappan sodiumalginatewithpegpeoblendsasafloatingdrugdeliverycarrierinvitroevaluation |