Systemic administration of β-glucan induces immune training in microglia

Systemic administration of β-glucan induces immune training in microglia

Abstract Background An innate immune memory response can manifest in two ways: immune training and immune tolerance, which refers to an enhanced or suppressed immune response to a second challenge, respectively. Exposing monocytes to moderate-to-high amounts of bacterial lipopolysaccharide (LPS) ind...

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Bibliographic Details
Main Authors: Yang Heng, Xiaoming Zhang, Malte Borggrewe, Hilmar R. J. van Weering, Maaike L. Brummer, Tjalling W. Nijboer, Leo A. B. Joosten, Mihai G. Netea, Erik W. G. M. Boddeke, Jon D. Laman, Bart J. L. Eggen
Format: Article
Language:English
Published: BMC 2021-02-01
Series:Journal of Neuroinflammation
Subjects:
microglia
innate immune memory
training
tolerance
β-glucan
lipopolysaccharide
Online Access:https://doi.org/10.1186/s12974-021-02103-4

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