Association of thyroid cancer with human papillomavirus infections
Abstract While Human Papillomavirus (HPV) particles have been detected in a small proportion of benign thyroid nodules or thyroid cancer cases, a role of HPV in these thyroid conditions has not been established. This study aims to investigate the association of HPV infection with thyroid cancer (TC)...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2024-01-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-49123-z |
| _version_ | 1797363347932315648 |
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| author | Tzong-Hann Yang Shih-Han Hung Yen-Fu Cheng Chin-Shyan Chen Herng-Ching Lin |
| author_facet | Tzong-Hann Yang Shih-Han Hung Yen-Fu Cheng Chin-Shyan Chen Herng-Ching Lin |
| author_sort | Tzong-Hann Yang |
| collection | DOAJ |
| description | Abstract While Human Papillomavirus (HPV) particles have been detected in a small proportion of benign thyroid nodules or thyroid cancer cases, a role of HPV in these thyroid conditions has not been established. This study aims to investigate the association of HPV infection with thyroid cancer (TC) using a nationwide population-based study. We retrieved data for this case–control study from Taiwan's Longitudinal Health Insurance Database 2010. The study sample included 3062 patients with TC and 9186 propensity-scored matched controls. We employed multivariate logistic regression models to quantitatively evaluate the association of TC with HPV infections after taking age, sex, monthly income, geographic location and urbanization level of the patient's residence, diabetes, hypertension, and hyperlipidemia into considerations. Chi-squared test revealed that there was a significant difference in the prevalence of prior HPV infections between patients with TC and controls (15.3% vs. 7.6%, p < 0.001). The adjusted odds ratio of prior HPV infections for patients with TC was 2.199 (95% CI = 1.939–2.492) relative to controls. The adjusted ORs of prior HPV infections for patients with TC was similar for males and females. Our research suggests a significant link between HPV infection and the development of TC. |
| first_indexed | 2024-03-08T16:19:04Z |
| format | Article |
| id | doaj.art-1567c15511f64233be0d884c5a2e62d1 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-03-08T16:19:04Z |
| publishDate | 2024-01-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-1567c15511f64233be0d884c5a2e62d12024-01-07T12:25:36ZengNature PortfolioScientific Reports2045-23222024-01-011411710.1038/s41598-023-49123-zAssociation of thyroid cancer with human papillomavirus infectionsTzong-Hann Yang0Shih-Han Hung1Yen-Fu Cheng2Chin-Shyan Chen3Herng-Ching Lin4Department of Otorhinolaryngology, Taipei City HospitalDepartment of Otolaryngology, School of Medicine, Taipei Medical UniversityDepartment of Medical Research, Taipei Veterans General HospitalResearch Center of Data Science on Healthcare Industry, College of Management, Taipei Medical UniversitySchool of Health Care Administration, College of Management, Taipei Medical UniversityAbstract While Human Papillomavirus (HPV) particles have been detected in a small proportion of benign thyroid nodules or thyroid cancer cases, a role of HPV in these thyroid conditions has not been established. This study aims to investigate the association of HPV infection with thyroid cancer (TC) using a nationwide population-based study. We retrieved data for this case–control study from Taiwan's Longitudinal Health Insurance Database 2010. The study sample included 3062 patients with TC and 9186 propensity-scored matched controls. We employed multivariate logistic regression models to quantitatively evaluate the association of TC with HPV infections after taking age, sex, monthly income, geographic location and urbanization level of the patient's residence, diabetes, hypertension, and hyperlipidemia into considerations. Chi-squared test revealed that there was a significant difference in the prevalence of prior HPV infections between patients with TC and controls (15.3% vs. 7.6%, p < 0.001). The adjusted odds ratio of prior HPV infections for patients with TC was 2.199 (95% CI = 1.939–2.492) relative to controls. The adjusted ORs of prior HPV infections for patients with TC was similar for males and females. Our research suggests a significant link between HPV infection and the development of TC.https://doi.org/10.1038/s41598-023-49123-z |
| spellingShingle | Tzong-Hann Yang Shih-Han Hung Yen-Fu Cheng Chin-Shyan Chen Herng-Ching Lin Association of thyroid cancer with human papillomavirus infections Scientific Reports |
| title | Association of thyroid cancer with human papillomavirus infections |
| title_full | Association of thyroid cancer with human papillomavirus infections |
| title_fullStr | Association of thyroid cancer with human papillomavirus infections |
| title_full_unstemmed | Association of thyroid cancer with human papillomavirus infections |
| title_short | Association of thyroid cancer with human papillomavirus infections |
| title_sort | association of thyroid cancer with human papillomavirus infections |
| url | https://doi.org/10.1038/s41598-023-49123-z |
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