Biological profile of medical response in alcoholic patients of different ethnic groups in Siberia
Introduction The individual sensitivity of a person to the effects of alcohol is defined as the possibility of adaptive reactions, which are controlled by various factors associated in their manifestation with characteristics in various ethnic populations. Objectives To determine biological prof...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Cambridge University Press
2021-04-01
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| Series: | European Psychiatry |
| Online Access: | https://www.cambridge.org/core/product/identifier/S0924933821018149/type/journal_article |
| _version_ | 1797616273066033152 |
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| author | T. Shushpanova T. Novozheeva N. Bokhan M. Belousov E. Bezverkhnyaya N. Kolomiets A. Mandel |
| author_facet | T. Shushpanova T. Novozheeva N. Bokhan M. Belousov E. Bezverkhnyaya N. Kolomiets A. Mandel |
| author_sort | T. Shushpanova |
| collection | DOAJ |
| description |
Introduction
The individual sensitivity of a person to the effects of alcohol is defined as the possibility of adaptive reactions, which are controlled by various factors associated in their manifestation with characteristics in various ethnic populations.
Objectives
To determine biological profile of medical response in alcoholic patients of different ethnic groups.
Methods
168 alcoholic men, aged 17 to 62 years were examined. For the therapeutic correction of withdrawal and post-withdrawal symptoms of patients from two different ethnic groups (Tatars and Russians in Siberia), the original anticonvulsant galodif (M-chloro-benzhydrylurea) was used. Pharmacokinetic parameters were calculated a model-independent method of statistical moments: half-life (T1/2,h), total clearance (Clt,ml/min), average time of the residual drug in the body (MRI,h), average elimination time (MET,h), the area under the pharmacokinetic curve (AUC, μg/ml).
Results
Galodif causes a reduction in almost half T1/2, a significant decrease in the average time of the residual drug in the body MRI, and the average elimination time MET. Overall clearance increased. Under the influence of the course with Galodif, antipyrine elimination intensified, which indicates the induction of the cytochrome P-450 system of microsomal liver monooxygenases in Russian alcoholic patients. Galodif causes a reduction of almost five-fold T1/2, a significant decrease MRI and MET. Activation of oxidative metabolism of xenobiotics in Tatar alcoholic patients is more significant.
Conclusions
The increased sensitivity of P-450 cytochrome system to anticonvulsants action with inductive detoxification properties reflects differences in adaptive mechanisms in human from various ethnic groups, what is significant in the therapy.
Disclosure
No significant relationships.
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| first_indexed | 2024-03-11T07:38:46Z |
| format | Article |
| id | doaj.art-156866d788b746998547d422f14f876e |
| institution | Directory Open Access Journal |
| issn | 0924-9338 1778-3585 |
| language | English |
| last_indexed | 2024-03-11T07:38:46Z |
| publishDate | 2021-04-01 |
| publisher | Cambridge University Press |
| record_format | Article |
| series | European Psychiatry |
| spelling | doaj.art-156866d788b746998547d422f14f876e2023-11-17T05:09:02ZengCambridge University PressEuropean Psychiatry0924-93381778-35852021-04-0164S685S68510.1192/j.eurpsy.2021.1814Biological profile of medical response in alcoholic patients of different ethnic groups in SiberiaT. Shushpanova0T. Novozheeva1N. Bokhan2M. Belousov3E. Bezverkhnyaya4N. Kolomiets5A. Mandel6Clinical Psychoneuroimmunology And Neurobiology Lab, Mental Health Research Institute, Tomsk, Russian FederationClinical Psychoneuroimmunology And Neurobiology Lab, Mental Health Research Institute, Tomsk, Russian Federation Neurobiology, Mental Health Research Institute Tomsk National Research Medical Center Russia Academy of Science, Tomsk, Russian FederationThe Department Of Addictive States, Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russian FederationDepartment Of Pharmaceutical Analysis, Siberian State Medical University, Tomsk, Russian FederationInstitute Of Physics Of High Technologies, Tomsk Polytechnic University, Tomsk, Russian FederationDepartment Of Pharmaceutical Analysis, Siberian State Medical University, Tomsk, Russian FederationThe Department Of Addictive States, Mental Health Research Institute, Tomsk National Research Medical Center of the Russian Academy of Sciences, Tomsk, Russian Federation Introduction The individual sensitivity of a person to the effects of alcohol is defined as the possibility of adaptive reactions, which are controlled by various factors associated in their manifestation with characteristics in various ethnic populations. Objectives To determine biological profile of medical response in alcoholic patients of different ethnic groups. Methods 168 alcoholic men, aged 17 to 62 years were examined. For the therapeutic correction of withdrawal and post-withdrawal symptoms of patients from two different ethnic groups (Tatars and Russians in Siberia), the original anticonvulsant galodif (M-chloro-benzhydrylurea) was used. Pharmacokinetic parameters were calculated a model-independent method of statistical moments: half-life (T1/2,h), total clearance (Clt,ml/min), average time of the residual drug in the body (MRI,h), average elimination time (MET,h), the area under the pharmacokinetic curve (AUC, μg/ml). Results Galodif causes a reduction in almost half T1/2, a significant decrease in the average time of the residual drug in the body MRI, and the average elimination time MET. Overall clearance increased. Under the influence of the course with Galodif, antipyrine elimination intensified, which indicates the induction of the cytochrome P-450 system of microsomal liver monooxygenases in Russian alcoholic patients. Galodif causes a reduction of almost five-fold T1/2, a significant decrease MRI and MET. Activation of oxidative metabolism of xenobiotics in Tatar alcoholic patients is more significant. Conclusions The increased sensitivity of P-450 cytochrome system to anticonvulsants action with inductive detoxification properties reflects differences in adaptive mechanisms in human from various ethnic groups, what is significant in the therapy. Disclosure No significant relationships. https://www.cambridge.org/core/product/identifier/S0924933821018149/type/journal_article |
| spellingShingle | T. Shushpanova T. Novozheeva N. Bokhan M. Belousov E. Bezverkhnyaya N. Kolomiets A. Mandel Biological profile of medical response in alcoholic patients of different ethnic groups in Siberia European Psychiatry |
| title | Biological profile of medical response in alcoholic patients of different ethnic groups in Siberia |
| title_full | Biological profile of medical response in alcoholic patients of different ethnic groups in Siberia |
| title_fullStr | Biological profile of medical response in alcoholic patients of different ethnic groups in Siberia |
| title_full_unstemmed | Biological profile of medical response in alcoholic patients of different ethnic groups in Siberia |
| title_short | Biological profile of medical response in alcoholic patients of different ethnic groups in Siberia |
| title_sort | biological profile of medical response in alcoholic patients of different ethnic groups in siberia |
| url | https://www.cambridge.org/core/product/identifier/S0924933821018149/type/journal_article |
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