Albocycline Is the Main Bioactive Antifungal Compound Produced by <i>Streptomyces</i> sp. OR6 against <i>Verticillium dahliae</i>
Verticillium wilt is a soil-borne fungal disease that affects olive trees (<i>Olea europaea</i>) and poses a serious threat to their cultivation. The causal agent of this disease is <i>Verticillium dahliae</i>, a pathogen that is difficult to control with conventional methods...
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MDPI AG
2023-10-01
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| Series: | Plants |
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| Online Access: | https://www.mdpi.com/2223-7747/12/20/3612 |
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| author | Carla Calvo-Peña Rebeca Cobos José María Sánchez-López Ana Ibañez Juan José R. Coque |
| author_facet | Carla Calvo-Peña Rebeca Cobos José María Sánchez-López Ana Ibañez Juan José R. Coque |
| author_sort | Carla Calvo-Peña |
| collection | DOAJ |
| description | Verticillium wilt is a soil-borne fungal disease that affects olive trees (<i>Olea europaea</i>) and poses a serious threat to their cultivation. The causal agent of this disease is <i>Verticillium dahliae</i>, a pathogen that is difficult to control with conventional methods. Therefore, there is a need to explore alternative strategies for the management of Verticillium wilt. In this study, we aimed to isolate and characterize actinobacteria from the rhizosphere of olive trees that could act as potential biocontrol agents against <i>V. dahliae</i>. We selected a <i>Streptomyces</i> sp. OR6 strain based on its in vitro antifungal activity and its ability to suppress the pathogen growth in soil samples. We identified the main active compound produced by this strain as albocycline, a macrolide polyketide with known antibacterial properties and some antifungal activity. Albocycline was able to efficiently suppress the germination of conidiospores. To our knowledge, this is the first report of albocycline as an effective agent against <i>V. dahliae</i>. Our results suggest that <i>Streptomyces</i> sp. OR6, or other albocycline-producing strains, could be used as a promising tool for the biological control of Verticillium wilt. |
| first_indexed | 2024-03-10T20:56:20Z |
| format | Article |
| id | doaj.art-1568be1c0acf4959b3451d865f318159 |
| institution | Directory Open Access Journal |
| issn | 2223-7747 |
| language | English |
| last_indexed | 2024-03-10T20:56:20Z |
| publishDate | 2023-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Plants |
| spelling | doaj.art-1568be1c0acf4959b3451d865f3181592023-11-19T17:49:29ZengMDPI AGPlants2223-77472023-10-011220361210.3390/plants12203612Albocycline Is the Main Bioactive Antifungal Compound Produced by <i>Streptomyces</i> sp. OR6 against <i>Verticillium dahliae</i>Carla Calvo-Peña0Rebeca Cobos1José María Sánchez-López2Ana Ibañez3Juan José R. Coque4Instituto de Investigación de la Viña y el Vino, Escuela de Ingeniería Agraria, Universidad de León, 24009 León, SpainInstituto de Investigación de la Viña y el Vino, Escuela de Ingeniería Agraria, Universidad de León, 24009 León, SpainBiomar Microbial Technologies, Armunia, 24009 León, SpainInstituto de Investigación de la Viña y el Vino, Escuela de Ingeniería Agraria, Universidad de León, 24009 León, SpainInstituto de Investigación de la Viña y el Vino, Escuela de Ingeniería Agraria, Universidad de León, 24009 León, SpainVerticillium wilt is a soil-borne fungal disease that affects olive trees (<i>Olea europaea</i>) and poses a serious threat to their cultivation. The causal agent of this disease is <i>Verticillium dahliae</i>, a pathogen that is difficult to control with conventional methods. Therefore, there is a need to explore alternative strategies for the management of Verticillium wilt. In this study, we aimed to isolate and characterize actinobacteria from the rhizosphere of olive trees that could act as potential biocontrol agents against <i>V. dahliae</i>. We selected a <i>Streptomyces</i> sp. OR6 strain based on its in vitro antifungal activity and its ability to suppress the pathogen growth in soil samples. We identified the main active compound produced by this strain as albocycline, a macrolide polyketide with known antibacterial properties and some antifungal activity. Albocycline was able to efficiently suppress the germination of conidiospores. To our knowledge, this is the first report of albocycline as an effective agent against <i>V. dahliae</i>. Our results suggest that <i>Streptomyces</i> sp. OR6, or other albocycline-producing strains, could be used as a promising tool for the biological control of Verticillium wilt.https://www.mdpi.com/2223-7747/12/20/3612<i>Verticillium dahliae</i>Verticillium wiltolivebiocontrolantifungalalbocycline |
| spellingShingle | Carla Calvo-Peña Rebeca Cobos José María Sánchez-López Ana Ibañez Juan José R. Coque Albocycline Is the Main Bioactive Antifungal Compound Produced by <i>Streptomyces</i> sp. OR6 against <i>Verticillium dahliae</i> Plants <i>Verticillium dahliae</i> Verticillium wilt olive biocontrol antifungal albocycline |
| title | Albocycline Is the Main Bioactive Antifungal Compound Produced by <i>Streptomyces</i> sp. OR6 against <i>Verticillium dahliae</i> |
| title_full | Albocycline Is the Main Bioactive Antifungal Compound Produced by <i>Streptomyces</i> sp. OR6 against <i>Verticillium dahliae</i> |
| title_fullStr | Albocycline Is the Main Bioactive Antifungal Compound Produced by <i>Streptomyces</i> sp. OR6 against <i>Verticillium dahliae</i> |
| title_full_unstemmed | Albocycline Is the Main Bioactive Antifungal Compound Produced by <i>Streptomyces</i> sp. OR6 against <i>Verticillium dahliae</i> |
| title_short | Albocycline Is the Main Bioactive Antifungal Compound Produced by <i>Streptomyces</i> sp. OR6 against <i>Verticillium dahliae</i> |
| title_sort | albocycline is the main bioactive antifungal compound produced by i streptomyces i sp or6 against i verticillium dahliae i |
| topic | <i>Verticillium dahliae</i> Verticillium wilt olive biocontrol antifungal albocycline |
| url | https://www.mdpi.com/2223-7747/12/20/3612 |
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