Applications and research progress of Traditional Chinese medicine delivered via nasal administration
Nasal administration of Traditional Chinese medicine (TCM) has a long history of applications. With the gradual maturing of technology and pharmacological advances, nasal preparations of TCM have undergone significant changes. Nasal TCM formulations are used not only for treatment of pneumonia, asth...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2023-01-01
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| Series: | Biomedicine & Pharmacotherapy |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0753332222013221 |
| _version_ | 1811179045504679936 |
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| author | Hongping Hou Yujie Li Ziying Xu Zihui Yu Bo Peng Caixia Wang Wei Liu Wei Li Zuguang Ye Guangping Zhang |
| author_facet | Hongping Hou Yujie Li Ziying Xu Zihui Yu Bo Peng Caixia Wang Wei Liu Wei Li Zuguang Ye Guangping Zhang |
| author_sort | Hongping Hou |
| collection | DOAJ |
| description | Nasal administration of Traditional Chinese medicine (TCM) has a long history of applications. With the gradual maturing of technology and pharmacological advances, nasal preparations of TCM have undergone significant changes. Nasal TCM formulations are used not only for treatment of pneumonia, asthma, sinusitis and allergic rhinitis but also Alzheimer's disease and Parkinson's disease, as antidepressants and antiepileptics, and in ischemia reperfusion. However, according to the analysis of nasal preparations of TCM currently on the market, most of them were compound preparations, which were used to treat allergic rhinitis (AR), common cold, headache and other local treatments, with a small range of diseases. At the same time, the dosage forms were mainly traditional dosage forms, aerosols and sprays, but there were no new dosage forms, which can not meet the clinical needs in terms of variety number, variety diversity and disease types. In this manuscript, we reviewed the development and applications of different nasal preparations of TCM from the aspects of nasal structure, origin, factors affecting absorption and common dosage forms, pharmacodynamics, targeting of nasal delivery and safety. In the near future, we expect that more nasal preparations of Chinese medicine with independent intellectual property rights will be marketed to meet the needs of clinical disease management. |
| first_indexed | 2024-04-11T06:28:01Z |
| format | Article |
| id | doaj.art-15695f20d31b41508bb8f18f0aa1573d |
| institution | Directory Open Access Journal |
| issn | 0753-3322 |
| language | English |
| last_indexed | 2024-04-11T06:28:01Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Biomedicine & Pharmacotherapy |
| spelling | doaj.art-15695f20d31b41508bb8f18f0aa1573d2022-12-22T04:40:15ZengElsevierBiomedicine & Pharmacotherapy0753-33222023-01-01157113933Applications and research progress of Traditional Chinese medicine delivered via nasal administrationHongping Hou0Yujie Li1Ziying Xu2Zihui Yu3Bo Peng4Caixia Wang5Wei Liu6Wei Li7Zuguang Ye8Guangping Zhang9Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, ChinaInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, ChinaCapital Institute of Pediatrics, Beijing 100020, ChinaCapital Institute of Pediatrics, Beijing 100020, ChinaInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, ChinaInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, ChinaState Key Laboratory of Respiratory Disease, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, The First Affiliated Hospital of Guangzhou Medical University, Guangzhou Medical University, Guangzhou 510120, ChinaSchool of Pharmaceutical Sciences (Shenzhen), Sun Yat-sen University, Shenzhen 518107, ChinaInstitute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China; Corresponding authors.Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China; Corresponding authors.Nasal administration of Traditional Chinese medicine (TCM) has a long history of applications. With the gradual maturing of technology and pharmacological advances, nasal preparations of TCM have undergone significant changes. Nasal TCM formulations are used not only for treatment of pneumonia, asthma, sinusitis and allergic rhinitis but also Alzheimer's disease and Parkinson's disease, as antidepressants and antiepileptics, and in ischemia reperfusion. However, according to the analysis of nasal preparations of TCM currently on the market, most of them were compound preparations, which were used to treat allergic rhinitis (AR), common cold, headache and other local treatments, with a small range of diseases. At the same time, the dosage forms were mainly traditional dosage forms, aerosols and sprays, but there were no new dosage forms, which can not meet the clinical needs in terms of variety number, variety diversity and disease types. In this manuscript, we reviewed the development and applications of different nasal preparations of TCM from the aspects of nasal structure, origin, factors affecting absorption and common dosage forms, pharmacodynamics, targeting of nasal delivery and safety. In the near future, we expect that more nasal preparations of Chinese medicine with independent intellectual property rights will be marketed to meet the needs of clinical disease management.http://www.sciencedirect.com/science/article/pii/S0753332222013221Nasal administrationTraditional Chinese MedicinePharmacodynamicsPharmacokineticsSafety |
| spellingShingle | Hongping Hou Yujie Li Ziying Xu Zihui Yu Bo Peng Caixia Wang Wei Liu Wei Li Zuguang Ye Guangping Zhang Applications and research progress of Traditional Chinese medicine delivered via nasal administration Biomedicine & Pharmacotherapy Nasal administration Traditional Chinese Medicine Pharmacodynamics Pharmacokinetics Safety |
| title | Applications and research progress of Traditional Chinese medicine delivered via nasal administration |
| title_full | Applications and research progress of Traditional Chinese medicine delivered via nasal administration |
| title_fullStr | Applications and research progress of Traditional Chinese medicine delivered via nasal administration |
| title_full_unstemmed | Applications and research progress of Traditional Chinese medicine delivered via nasal administration |
| title_short | Applications and research progress of Traditional Chinese medicine delivered via nasal administration |
| title_sort | applications and research progress of traditional chinese medicine delivered via nasal administration |
| topic | Nasal administration Traditional Chinese Medicine Pharmacodynamics Pharmacokinetics Safety |
| url | http://www.sciencedirect.com/science/article/pii/S0753332222013221 |
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