The local efficacy and influencing factors of ultrasound-guided percutaneous microwave ablation in colorectal liver metastases: a review of a 4-year experience at a single center
Purpose: To investigate the clinical effectiveness and safety of ultrasound (US)-guided percutaneous microwave ablation (MWA) for colorectal liver metastasis (CRLM) and evaluate the influencing factors of local efficacy. Methods: From January 2013 to January 2017, 137 CRLM patients accepting US-guid...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-01-01
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| Series: | International Journal of Hyperthermia |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/02656736.2018.1528511 |
| _version_ | 1824012091565015040 |
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| author | Si Qin Guang-Jian Liu Meijin Huang Jun Huang Yanxin Luo Yanling Wen Yimin Wang Limei Chen |
| author_facet | Si Qin Guang-Jian Liu Meijin Huang Jun Huang Yanxin Luo Yanling Wen Yimin Wang Limei Chen |
| author_sort | Si Qin |
| collection | DOAJ |
| description | Purpose: To investigate the clinical effectiveness and safety of ultrasound (US)-guided percutaneous microwave ablation (MWA) for colorectal liver metastasis (CRLM) and evaluate the influencing factors of local efficacy. Methods: From January 2013 to January 2017, 137 CRLM patients accepting US-guided percutaneous MWA were included. The 2450-MHz microwave ablation system and a cooled-shaft antenna were used. All patients were regularly followed up for at least 6 months. Technical success, complete ablation, local tumor progression (LTP), complications and side effects were assessed. Logistic regression analysis was used to identify the independent prognostic factors for LTP. Results: In total, 411 lesions (mean diameter 15.4 ± 7.2 mm, range 5–67 mm) were treated. Complete ablation was achieved in 99.27% (408/411) of lesions and 97.81% (134/137) of patients. LTP occurred in 5.35% (22/411) of lesions and 16.06% (22/137) of patients. LTP was more likely to occur in lesions larger than 3 cm in diameter (OR: 14.71; p < .001; 95% CI: 3.7 3–57.92), near a large vascular structure (OR: 7.04; p < .001; 95% CI: 2.41–20.60), near the diaphragm (OR: 4.02; p = .049; 95% CI: 1.05–16.11) and in patients with no response to chemotherapy before MWA (OR: 3.25; p = .032; 95% CI: 1.14–15.30). MWA was well tolerated, with a major complication rate of 3.65%, a minor complication rate of 8.03% and a mortality rate of 0%. Fever and pain were the most common side effects after MWA. Conclusions: US-guided percutaneous MWA of CRLM is a safe and effective method that is expected to become a routine treatment for local tumor control of CRLM. |
| first_indexed | 2024-12-18T21:44:32Z |
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| id | doaj.art-15699c200cb149c493e650b727380192 |
| institution | Directory Open Access Journal |
| issn | 0265-6736 1464-5157 |
| language | English |
| last_indexed | 2024-12-18T21:44:32Z |
| publishDate | 2019-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj.art-15699c200cb149c493e650b7273801922022-12-21T20:50:44ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572019-01-01361364310.1080/02656736.2018.15285111528511The local efficacy and influencing factors of ultrasound-guided percutaneous microwave ablation in colorectal liver metastases: a review of a 4-year experience at a single centerSi Qin0Guang-Jian Liu1Meijin Huang2Jun Huang3Yanxin Luo4Yanling Wen5Yimin Wang6Limei Chen7The Sixth Affiliated Hospital of Sun Yat-Sen UniversityThe Sixth Affiliated Hospital of Sun Yat-Sen UniversityThe Sixth Affiliated Hospital of Sun Yat-Sen UniversityThe Sixth Affiliated Hospital of Sun Yat-Sen UniversityThe Sixth Affiliated Hospital of Sun Yat-Sen UniversityThe Sixth Affiliated Hospital of Sun Yat-Sen UniversityThe Sixth Affiliated Hospital of Sun Yat-Sen UniversityThe Sixth Affiliated Hospital of Sun Yat-Sen UniversityPurpose: To investigate the clinical effectiveness and safety of ultrasound (US)-guided percutaneous microwave ablation (MWA) for colorectal liver metastasis (CRLM) and evaluate the influencing factors of local efficacy. Methods: From January 2013 to January 2017, 137 CRLM patients accepting US-guided percutaneous MWA were included. The 2450-MHz microwave ablation system and a cooled-shaft antenna were used. All patients were regularly followed up for at least 6 months. Technical success, complete ablation, local tumor progression (LTP), complications and side effects were assessed. Logistic regression analysis was used to identify the independent prognostic factors for LTP. Results: In total, 411 lesions (mean diameter 15.4 ± 7.2 mm, range 5–67 mm) were treated. Complete ablation was achieved in 99.27% (408/411) of lesions and 97.81% (134/137) of patients. LTP occurred in 5.35% (22/411) of lesions and 16.06% (22/137) of patients. LTP was more likely to occur in lesions larger than 3 cm in diameter (OR: 14.71; p < .001; 95% CI: 3.7 3–57.92), near a large vascular structure (OR: 7.04; p < .001; 95% CI: 2.41–20.60), near the diaphragm (OR: 4.02; p = .049; 95% CI: 1.05–16.11) and in patients with no response to chemotherapy before MWA (OR: 3.25; p = .032; 95% CI: 1.14–15.30). MWA was well tolerated, with a major complication rate of 3.65%, a minor complication rate of 8.03% and a mortality rate of 0%. Fever and pain were the most common side effects after MWA. Conclusions: US-guided percutaneous MWA of CRLM is a safe and effective method that is expected to become a routine treatment for local tumor control of CRLM.http://dx.doi.org/10.1080/02656736.2018.1528511ultrasoundpercutaneousmicrowave ablationlivermetastaseslocal efficacy |
| spellingShingle | Si Qin Guang-Jian Liu Meijin Huang Jun Huang Yanxin Luo Yanling Wen Yimin Wang Limei Chen The local efficacy and influencing factors of ultrasound-guided percutaneous microwave ablation in colorectal liver metastases: a review of a 4-year experience at a single center International Journal of Hyperthermia ultrasound percutaneous microwave ablation liver metastases local efficacy |
| title | The local efficacy and influencing factors of ultrasound-guided percutaneous microwave ablation in colorectal liver metastases: a review of a 4-year experience at a single center |
| title_full | The local efficacy and influencing factors of ultrasound-guided percutaneous microwave ablation in colorectal liver metastases: a review of a 4-year experience at a single center |
| title_fullStr | The local efficacy and influencing factors of ultrasound-guided percutaneous microwave ablation in colorectal liver metastases: a review of a 4-year experience at a single center |
| title_full_unstemmed | The local efficacy and influencing factors of ultrasound-guided percutaneous microwave ablation in colorectal liver metastases: a review of a 4-year experience at a single center |
| title_short | The local efficacy and influencing factors of ultrasound-guided percutaneous microwave ablation in colorectal liver metastases: a review of a 4-year experience at a single center |
| title_sort | local efficacy and influencing factors of ultrasound guided percutaneous microwave ablation in colorectal liver metastases a review of a 4 year experience at a single center |
| topic | ultrasound percutaneous microwave ablation liver metastases local efficacy |
| url | http://dx.doi.org/10.1080/02656736.2018.1528511 |
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