Split-DNAzyme cooperating primer exchange reaction for sensitive miRNA detection

Split-DNAzyme cooperating primer exchange reaction for sensitive miRNA detection

Abstract Sensitive quantification of microRNA (miRNA) plays a crucial role in early diagnosis and precise therapy of osteosarcoma. Herein, we build a label-free and sensitive miRNA quantification approach based on the activation of split-DNAzyme initiated primer exchange reaction (PER). Target miRNA...

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Bibliographic Details
Main Authors: Xuguo Luo, Hongze Wu, Mingjie Xiong, Liyun Jiang, Zhihao Jiang, Minyong Gong
Format: Article
Language:English
Published: SpringerOpen 2022-10-01
Series:Journal of Analytical Science and Technology
Subjects:
Osteosarcoma
MicroRNA (miRNA)
N-methyl mesoporphyrin IX
Primer exchange reaction (PER)
Online Access:https://doi.org/10.1186/s40543-022-00343-4

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