Susceptibility to Bismuth(III) of Aquaculture Bacterial Pathogens: Effectiveness of Bismuth–Deferiprone Therapy against <i>Vibrio anguillarum</i> Infection in Fish
Bismuth is a heavy metal with antibacterial properties that has a long history of medicinal use. The results reported here suggest that bismuth(III) (chelated with deferiprone) could be used in aquaculture systems to treat bacterial disease outbreaks, greatly reducing antibiotic use. We tested bismu...
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MDPI AG
2021-11-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/9/11/2399 |
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| author | Miguel Balado Diego Rey-Varela Ana M. Albela Manuel L. Lemos |
| author_facet | Miguel Balado Diego Rey-Varela Ana M. Albela Manuel L. Lemos |
| author_sort | Miguel Balado |
| collection | DOAJ |
| description | Bismuth is a heavy metal with antibacterial properties that has a long history of medicinal use. The results reported here suggest that bismuth(III) (chelated with deferiprone) could be used in aquaculture systems to treat bacterial disease outbreaks, greatly reducing antibiotic use. We tested bismuth susceptibility in a collection of aquaculture bacterial pathogens. In the presence of bismuth concentrations ranging from 1.3 to 13 µM, most bacteria started showing a drastic decrease in their growth ability, although with high inter- and intraspecific variability. The minimal inhibitory concentrations of bismuth ranged from 13 to more than 780 µM, depending on bacterial species and strain. The results of in vivo assays suggest that low concentrations of bismuth could be especially effective to treat vibriosis caused by <i>Vibrio anguillarum,</i> since bismuth greatly reduced mortality in experimentally infected fish without any observable side effects. A bismuth therapy, alone or combined with other antimicrobials, could contribute to reduce the use of antibiotics in aquaculture. |
| first_indexed | 2024-03-10T05:14:28Z |
| format | Article |
| id | doaj.art-156cc78d29b64b169f7ff2d771cceac9 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T05:14:28Z |
| publishDate | 2021-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-156cc78d29b64b169f7ff2d771cceac92023-11-23T00:30:53ZengMDPI AGMicroorganisms2076-26072021-11-01911239910.3390/microorganisms9112399Susceptibility to Bismuth(III) of Aquaculture Bacterial Pathogens: Effectiveness of Bismuth–Deferiprone Therapy against <i>Vibrio anguillarum</i> Infection in FishMiguel Balado0Diego Rey-Varela1Ana M. Albela2Manuel L. Lemos3Department of Microbiology and Parasitology, Institute of Aquaculture, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, SpainDepartment of Microbiology and Parasitology, Institute of Aquaculture, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, SpainDepartment of Microbiology and Parasitology, Institute of Aquaculture, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, SpainDepartment of Microbiology and Parasitology, Institute of Aquaculture, Universidade de Santiago de Compostela, 15782 Santiago de Compostela, SpainBismuth is a heavy metal with antibacterial properties that has a long history of medicinal use. The results reported here suggest that bismuth(III) (chelated with deferiprone) could be used in aquaculture systems to treat bacterial disease outbreaks, greatly reducing antibiotic use. We tested bismuth susceptibility in a collection of aquaculture bacterial pathogens. In the presence of bismuth concentrations ranging from 1.3 to 13 µM, most bacteria started showing a drastic decrease in their growth ability, although with high inter- and intraspecific variability. The minimal inhibitory concentrations of bismuth ranged from 13 to more than 780 µM, depending on bacterial species and strain. The results of in vivo assays suggest that low concentrations of bismuth could be especially effective to treat vibriosis caused by <i>Vibrio anguillarum,</i> since bismuth greatly reduced mortality in experimentally infected fish without any observable side effects. A bismuth therapy, alone or combined with other antimicrobials, could contribute to reduce the use of antibiotics in aquaculture.https://www.mdpi.com/2076-2607/9/11/2399aquaculturebacterial pathogensvibriosis<i>Vibrio anguillarum</i>bismuth |
| spellingShingle | Miguel Balado Diego Rey-Varela Ana M. Albela Manuel L. Lemos Susceptibility to Bismuth(III) of Aquaculture Bacterial Pathogens: Effectiveness of Bismuth–Deferiprone Therapy against <i>Vibrio anguillarum</i> Infection in Fish Microorganisms aquaculture bacterial pathogens vibriosis <i>Vibrio anguillarum</i> bismuth |
| title | Susceptibility to Bismuth(III) of Aquaculture Bacterial Pathogens: Effectiveness of Bismuth–Deferiprone Therapy against <i>Vibrio anguillarum</i> Infection in Fish |
| title_full | Susceptibility to Bismuth(III) of Aquaculture Bacterial Pathogens: Effectiveness of Bismuth–Deferiprone Therapy against <i>Vibrio anguillarum</i> Infection in Fish |
| title_fullStr | Susceptibility to Bismuth(III) of Aquaculture Bacterial Pathogens: Effectiveness of Bismuth–Deferiprone Therapy against <i>Vibrio anguillarum</i> Infection in Fish |
| title_full_unstemmed | Susceptibility to Bismuth(III) of Aquaculture Bacterial Pathogens: Effectiveness of Bismuth–Deferiprone Therapy against <i>Vibrio anguillarum</i> Infection in Fish |
| title_short | Susceptibility to Bismuth(III) of Aquaculture Bacterial Pathogens: Effectiveness of Bismuth–Deferiprone Therapy against <i>Vibrio anguillarum</i> Infection in Fish |
| title_sort | susceptibility to bismuth iii of aquaculture bacterial pathogens effectiveness of bismuth deferiprone therapy against i vibrio anguillarum i infection in fish |
| topic | aquaculture bacterial pathogens vibriosis <i>Vibrio anguillarum</i> bismuth |
| url | https://www.mdpi.com/2076-2607/9/11/2399 |
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