Effect of transcatheter aortic valve replacement on ascending aorta dilatation rate in patients with tricuspid and bicuspid aortic stenosis
Objectives: The aim of the present study was to assess the differences between BAV and TAV patients with chronic moderate to severe or severe AS regarding presentation, incidence of TAVR, survival, ascending aorta diameter and dilatation rate before and after TAVR. Methods: The study included 667 co...
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| Format: | Article |
| Language: | English |
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Elsevier
2023-12-01
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| Series: | International Journal of Cardiology: Heart & Vasculature |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352906723001446 |
| _version_ | 1797398545935892480 |
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| author | Hua-Jie Zheng Yong-Bo Cheng De-Qing Lin Chao-Jun Yan San-Jiu Yu Ping He Jun Li Wei Cheng |
| author_facet | Hua-Jie Zheng Yong-Bo Cheng De-Qing Lin Chao-Jun Yan San-Jiu Yu Ping He Jun Li Wei Cheng |
| author_sort | Hua-Jie Zheng |
| collection | DOAJ |
| description | Objectives: The aim of the present study was to assess the differences between BAV and TAV patients with chronic moderate to severe or severe AS regarding presentation, incidence of TAVR, survival, ascending aorta diameter and dilatation rate before and after TAVR. Methods: The study included 667 consecutive patients with chronic moderate to severe or severe AS from January 2012 and December 2022. Outcomes included all-cause mortality, incidence of TAVR, and ascending aorta diameter and dilatation rate. Results: There were 185 BAV-AS and 482 TAV-AS patients, and BAV-AS patients were younger (67 vs 78 years, P = 0.027). Total follow-up was 4.5 years (IQR: 2.7-8.9 years), 290 patients underwent TAVR, and 165 patients died. The 8-year TAVR incidence was higher in BAV-AS (55% ± 4%) vs TAV-AS (41% ± 5%; P = 0.02). The 8-year survival was higher in BAV-AS (85% ± 6%) vs TAV-AS (71% ± 6%; P < 0.0001) and became insignificant after age adjustment (P = 0.33). The dilatation rate of ascending aorta was significantly faster in BAV-AS patients compared with TAV-AS patients before TAVR. However, the ascending aorta dilatation rate for BAV-AS and TAV-AS patients was not significantly different after TAVR. Conclusions: Compared with TAV-AS, BAV-AS patients were younger and underwent TAVR more frequently, resulting in a considerable survival advantage. After TAVR, ascending aorta dilatation rates were similar in BAV-AS and TAV-AS patients, suggesting an important role of hemodynamics on ascending aorta dilatation in BAV-AS. |
| first_indexed | 2024-03-09T01:27:02Z |
| format | Article |
| id | doaj.art-156d0fb7fe01466fa5fba22e826e5d74 |
| institution | Directory Open Access Journal |
| issn | 2352-9067 |
| language | English |
| last_indexed | 2024-03-09T01:27:02Z |
| publishDate | 2023-12-01 |
| publisher | Elsevier |
| record_format | Article |
| series | International Journal of Cardiology: Heart & Vasculature |
| spelling | doaj.art-156d0fb7fe01466fa5fba22e826e5d742023-12-10T06:16:34ZengElsevierInternational Journal of Cardiology: Heart & Vasculature2352-90672023-12-0149101313Effect of transcatheter aortic valve replacement on ascending aorta dilatation rate in patients with tricuspid and bicuspid aortic stenosisHua-Jie Zheng0Yong-Bo Cheng1De-Qing Lin2Chao-Jun Yan3San-Jiu Yu4Ping He5Jun Li6Wei Cheng7Department of Cardiac Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Cardiac Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Cardiac Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Cardiac Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Cardiac Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaDepartment of Cardiac Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaCorresponding authors at: Department of Cardiac Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), No.30, Gaotanyan Road, Shapingba District, Chongqing 400038, China.; Department of Cardiac Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaCorresponding authors at: Department of Cardiac Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), No.30, Gaotanyan Road, Shapingba District, Chongqing 400038, China.; Department of Cardiac Surgery, Southwest Hospital, Third Military Medical University (Army Medical University), Chongqing, ChinaObjectives: The aim of the present study was to assess the differences between BAV and TAV patients with chronic moderate to severe or severe AS regarding presentation, incidence of TAVR, survival, ascending aorta diameter and dilatation rate before and after TAVR. Methods: The study included 667 consecutive patients with chronic moderate to severe or severe AS from January 2012 and December 2022. Outcomes included all-cause mortality, incidence of TAVR, and ascending aorta diameter and dilatation rate. Results: There were 185 BAV-AS and 482 TAV-AS patients, and BAV-AS patients were younger (67 vs 78 years, P = 0.027). Total follow-up was 4.5 years (IQR: 2.7-8.9 years), 290 patients underwent TAVR, and 165 patients died. The 8-year TAVR incidence was higher in BAV-AS (55% ± 4%) vs TAV-AS (41% ± 5%; P = 0.02). The 8-year survival was higher in BAV-AS (85% ± 6%) vs TAV-AS (71% ± 6%; P < 0.0001) and became insignificant after age adjustment (P = 0.33). The dilatation rate of ascending aorta was significantly faster in BAV-AS patients compared with TAV-AS patients before TAVR. However, the ascending aorta dilatation rate for BAV-AS and TAV-AS patients was not significantly different after TAVR. Conclusions: Compared with TAV-AS, BAV-AS patients were younger and underwent TAVR more frequently, resulting in a considerable survival advantage. After TAVR, ascending aorta dilatation rates were similar in BAV-AS and TAV-AS patients, suggesting an important role of hemodynamics on ascending aorta dilatation in BAV-AS.http://www.sciencedirect.com/science/article/pii/S2352906723001446Transcatheter aortic valve replacementBicuspid aortic valveTricuspid aortic valveAortic stenosisAscending aorta dilatation |
| spellingShingle | Hua-Jie Zheng Yong-Bo Cheng De-Qing Lin Chao-Jun Yan San-Jiu Yu Ping He Jun Li Wei Cheng Effect of transcatheter aortic valve replacement on ascending aorta dilatation rate in patients with tricuspid and bicuspid aortic stenosis International Journal of Cardiology: Heart & Vasculature Transcatheter aortic valve replacement Bicuspid aortic valve Tricuspid aortic valve Aortic stenosis Ascending aorta dilatation |
| title | Effect of transcatheter aortic valve replacement on ascending aorta dilatation rate in patients with tricuspid and bicuspid aortic stenosis |
| title_full | Effect of transcatheter aortic valve replacement on ascending aorta dilatation rate in patients with tricuspid and bicuspid aortic stenosis |
| title_fullStr | Effect of transcatheter aortic valve replacement on ascending aorta dilatation rate in patients with tricuspid and bicuspid aortic stenosis |
| title_full_unstemmed | Effect of transcatheter aortic valve replacement on ascending aorta dilatation rate in patients with tricuspid and bicuspid aortic stenosis |
| title_short | Effect of transcatheter aortic valve replacement on ascending aorta dilatation rate in patients with tricuspid and bicuspid aortic stenosis |
| title_sort | effect of transcatheter aortic valve replacement on ascending aorta dilatation rate in patients with tricuspid and bicuspid aortic stenosis |
| topic | Transcatheter aortic valve replacement Bicuspid aortic valve Tricuspid aortic valve Aortic stenosis Ascending aorta dilatation |
| url | http://www.sciencedirect.com/science/article/pii/S2352906723001446 |
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