Solution NMR of Nanoparticles in Serum: Protein Competition Influences Binding Thermodynamics and Kinetics

Solution NMR of Nanoparticles in Serum: Protein Competition Influences Binding Thermodynamics and Kinetics

The spontaneous formation of a protein corona on a nanoparticle surface influences the physiological success or failure of the synthetic nanoparticle as a drug carrier or imaging agent used in vivo. A quantitative understanding of protein-nanoparticle interactions is therefore critical for the devel...

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Bibliographic Details
Main Authors: Joanna Xiuzhu Xu, Nicholas C. Fitzkee
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-08-01
Series:Frontiers in Physiology
Subjects:
nanoparticle
protein
binding
interaction
NMR
kinetics
Online Access:https://www.frontiersin.org/articles/10.3389/fphys.2021.715419/full

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